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PXN paxillin [ Homo sapiens (human) ]

Gene ID: 5829, updated on 25-Jan-2015
Official Symbol
PXNprovided by HGNC
Official Full Name
paxillinprovided by HGNC
Primary source
HGNC:HGNC:9718
Locus tag
hCG_1778014
See related
Ensembl:ENSG00000089159; MIM:602505; Vega:OTTHUMG00000169169
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Alternatively spliced transcript variants encoding different isoforms have been described for this gene. These isoforms exhibit different expression pattern, and have different biochemical, as well as physiological properties (PMID:9054445). [provided by RefSeq, Aug 2011]
Orthologs
See PXN in MapViewer
Location:
12q24.31
Exon count:
20
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 12 NC_000012.12 (120210439..120265771, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (120648242..120703574, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene GCN1 general control of amino-acid synthesis 1-like 1 (yeast) Neighboring gene microRNA 4498 Neighboring gene ribosomal protein, large, P0 Neighboring gene PXN antisense RNA 1 Neighboring gene ribosomal protein S20 pseudogene 31 Neighboring gene NME/NM23 nucleoside diphosphate kinase 2 pseudogene 1 Neighboring gene RNA, U4 small nuclear 2

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env SLIT2N, an active fragment of SLIT2, inhibits M-tropic HIV-1 gp120-induced Src signaling and activation of its downstream targets Pyk2, CDC42, Rac1, and paxillin in immature monocyte-derived dendritic cells PubMed
Nef nef The Nef/hnRNPK/PKC-delta/Hck protein complex activates Pak2 activity but inhibits Pak1 activity, which induces paxillin phosphorylation on Ser272/274 and regulates paxillin/TACE association and secretion PubMed
nef The Nef/hnRNPK/PKC-delta/Hck protein complex increases paxillin phosphorylation at Y118 and activates and secretes TACE through Erk1/2 activation PubMed
Tat tat Endothelial cell adherent to HIV-1 Tat induces upregulation of VEGFR2, integrin beta(3) subunit, pp60src and recruits VEGFR2, integrin beta(3) subunit, paxillin, focal adhesion kinase, and pp60src to ventral plasma membranes PubMed
tat HIV-1 Tat stimulates the phosphorylation of paxillin and its association with RAFTK, an effect linked to Tat-induced angiogenesis and AIDS-related Kaposi's sarcoma PubMed
matrix gag HIV-1 MA co-localizes with beta2 integrin, alphaM and alphaX integrins in the intracellular thick electron-dense membrane compartments, which contain talin, vinculin and paxillin that connect the integrin complexes to the actin cytoskeleton PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ16691

Gene Ontology Provided by GOA

Function Evidence Code Pubs
BH4 domain binding IEA
Inferred from Electronic Annotation
more info
 
beta-catenin binding IPI
Inferred from Physical Interaction
more info
PubMed 
integrin binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IEA
Inferred from Electronic Annotation
more info
 
vinculin binding IPI
Inferred from Physical Interaction
more info
PubMed 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
activation of MAPK activity IEA
Inferred from Electronic Annotation
more info
 
branching morphogenesis of an epithelial tube IEA
Inferred from Electronic Annotation
more info
 
cell adhesion NAS
Non-traceable Author Statement
more info
PubMed 
cell junction assembly TAS
Traceable Author Statement
more info
 
cellular response to reactive oxygen species IEP
Inferred from Expression Pattern
more info
PubMed 
cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 
epidermal growth factor receptor signaling pathway TAS
Traceable Author Statement
more info
 
focal adhesion assembly IEA
Inferred from Electronic Annotation
more info
 
growth hormone receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
integrin-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
lamellipodium assembly IEA
Inferred from Electronic Annotation
more info
 
movement of cell or subcellular component IEA
Inferred from Electronic Annotation
more info
 
muscle contraction TAS
Traceable Author Statement
more info
 
peptidyl-tyrosine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
regulation of cell shape IEA
Inferred from Electronic Annotation
more info
 
signal complex assembly TAS
Traceable Author Statement
more info
PubMed 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
substrate adhesion-dependent cell spreading IEA
Inferred from Electronic Annotation
more info
 
transforming growth factor beta receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
vascular endothelial growth factor receptor signaling pathway TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cell cortex IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
focal adhesion IDA
Inferred from Direct Assay
more info
 
lamellipodium IDA
Inferred from Direct Assay
more info
PubMed 
microtubule associated complex TAS
Traceable Author Statement
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
stress fiber IDA
Inferred from Direct Assay
more info
PubMed 

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029820.1 

    Range
    5001..60333
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001080855.2NP_001074324.1  paxillin isoform 2

    See proteins identical to NP_001074324.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has an additional in-frame coding exon compared to variant 1. This results in a longer isoform (2, also known as isoform beta) containing a 34 aa protein segment not found in isoform 1.
    Source sequence(s)
    AA922640, BC144410, BU500419, BX648777, DB472926
    Consensus CDS
    CCDS44997.1
    UniProtKB/Swiss-Prot
    P49023
    Related
    ENSP00000228307, OTTHUMP00000240291, ENST00000228307, OTTHUMT00000402679
    Conserved Domains (5) summary
    cd09338
    Location:476528
    LIM3_Paxillin_like; The third LIM domain of the paxillin like protein family
    cd09407
    Location:417468
    LIM2_Paxillin; The second LIM domain of paxillin
    cd09411
    Location:535586
    LIM4_Paxillin; The fourth LIM domain of Paxillin
    pfam03535
    Location:54253
    Paxillin; Paxillin family
    cd09336
    Location:358410
    LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family
  2. NM_001243756.1NP_001230685.1  paxillin isoform 3

    See proteins identical to NP_001230685.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame acceptor splice site at an internal coding exon compared to variant 1. This results in a longer isoform (3, also known as isoform gamma) containing a 48 aa protein segment not found in isoform 1.
    Source sequence(s)
    AA922640, BC136794, BC144410, BU500419, BX648777, D86863, DB472926
    Consensus CDS
    CCDS58281.1
    UniProtKB/Swiss-Prot
    P49023
    Related
    ENSP00000267257, ENST00000267257
    Conserved Domains (5) summary
    cd09338
    Location:490542
    LIM3_Paxillin_like; The third LIM domain of the paxillin like protein family
    cd09407
    Location:431482
    LIM2_Paxillin; The second LIM domain of paxillin
    cd09411
    Location:549600
    LIM4_Paxillin; The fourth LIM domain of Paxillin
    pfam03535
    Location:54253
    Paxillin; Paxillin family
    cd09336
    Location:372424
    LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family
  3. NM_002859.3NP_002850.2  paxillin isoform 1

    See proteins identical to NP_002850.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript, and encodes isoform 1 (also known as isoform alpha).
    Source sequence(s)
    AA922640, BC136794, BC144410, BU500419, BX648777, DB472926
    Consensus CDS
    CCDS44996.1
    UniProtKB/Swiss-Prot
    P49023
    Related
    ENSP00000391283, OTTHUMP00000240317, ENST00000424649, OTTHUMT00000402713
    Conserved Domains (5) summary
    cd09338
    Location:442494
    LIM3_Paxillin_like; The third LIM domain of the paxillin like protein family
    cd09407
    Location:383434
    LIM2_Paxillin; The second LIM domain of paxillin
    cd09411
    Location:501552
    LIM4_Paxillin; The fourth LIM domain of Paxillin
    pfam03535
    Location:54253
    Paxillin; Paxillin family
    cd09336
    Location:324376
    LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family
  4. NM_025157.4NP_079433.3  paxillin isoform 4

    See proteins identical to NP_079433.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) contains an alternate 5' terminal exon compared to variant 1. This results in translation initiation from an in-frame downstream AUG, and an isoform (4) with a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AA922640, BC136794, BC144410, BU500419, BX648777, DA565031
    Consensus CDS
    CCDS44998.1
    UniProtKB/Swiss-Prot
    P49023
    Related
    ENSP00000395536, OTTHUMP00000240326, ENST00000458477, OTTHUMT00000402736
    Conserved Domains (4) summary
    cd09338
    Location:309361
    LIM3_Paxillin_like; The third LIM domain of the paxillin like protein family
    pfam03535
    Location:1120
    Paxillin; Paxillin family
    cd09336
    Location:191243
    LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family
    cl02475
    Location:250301
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000012.12 

    Range
    120210439..120265771
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006719532.1XP_006719595.1  

    Conserved Domains (5) summary
    cd09338
    Location:10141066
    LIM3_Paxillin_like; The third LIM domain of the paxillin like protein family
    cd09407
    Location:9551006
    LIM2_Paxillin; The second LIM domain of paxillin
    cd09411
    Location:10731124
    LIM4_Paxillin; The fourth LIM domain of Paxillin
    pfam03535
    Location:54253
    Paxillin; Paxillin family
    cd09336
    Location:896948
    LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family
  2. XM_005253915.1XP_005253972.1  

    UniProtKB/TrEMBL
    F5GZ78
    Related
    ENSP00000443887, OTTHUMP00000240327, ENST00000536957, OTTHUMT00000402737
    Conserved Domains (5) summary
    cd09338
    Location:474526
    LIM3_Paxillin_like; The third LIM domain of the paxillin like protein family
    cd09407
    Location:415466
    LIM2_Paxillin; The second LIM domain of paxillin
    cd09411
    Location:533584
    LIM4_Paxillin; The fourth LIM domain of Paxillin
    pfam03535
    Location:52251
    Paxillin; Paxillin family
    cd09336
    Location:356408
    LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family
  3. XM_006719533.1XP_006719596.1  

    Conserved Domains (5) summary
    cd09338
    Location:10121064
    LIM3_Paxillin_like; The third LIM domain of the paxillin like protein family
    cd09407
    Location:9531004
    LIM2_Paxillin; The second LIM domain of paxillin
    cd09411
    Location:10711122
    LIM4_Paxillin; The fourth LIM domain of Paxillin
    pfam03535
    Location:52251
    Paxillin; Paxillin family
    cd09336
    Location:894946
    LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family
  4. XM_005253916.1XP_005253973.1  

    Conserved Domains (5) summary
    cd09338
    Location:448500
    LIM3_Paxillin_like; The third LIM domain of the paxillin like protein family
    cd09407
    Location:389440
    LIM2_Paxillin; The second LIM domain of paxillin
    cd09411
    Location:507558
    LIM4_Paxillin; The fourth LIM domain of Paxillin
    pfam03535
    Location:60259
    Paxillin; Paxillin family
    cd09336
    Location:330382
    LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family
  5. XM_005253913.1XP_005253970.1  

    Conserved Domains (5) summary
    cd09338
    Location:496548
    LIM3_Paxillin_like; The third LIM domain of the paxillin like protein family
    cd09407
    Location:437488
    LIM2_Paxillin; The second LIM domain of paxillin
    cd09411
    Location:555606
    LIM4_Paxillin; The fourth LIM domain of Paxillin
    pfam03535
    Location:60259
    Paxillin; Paxillin family
    cd09336
    Location:378430
    LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family
  6. XM_005253914.1XP_005253971.1  

    Conserved Domains (5) summary
    cd09338
    Location:482534
    LIM3_Paxillin_like; The third LIM domain of the paxillin like protein family
    cd09407
    Location:423474
    LIM2_Paxillin; The second LIM domain of paxillin
    cd09411
    Location:541592
    LIM4_Paxillin; The fourth LIM domain of Paxillin
    pfam03535
    Location:60259
    Paxillin; Paxillin family
    cd09336
    Location:364416
    LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family
  7. XM_006719539.1XP_006719602.1  

    Conserved Domains (5) summary
    cd09338
    Location:530582
    LIM3_Paxillin_like; The third LIM domain of the paxillin like protein family
    cd09407
    Location:471522
    LIM2_Paxillin; The second LIM domain of paxillin
    cd09411
    Location:589640
    LIM4_Paxillin; The fourth LIM domain of Paxillin
    pfam03535
    Location:60259
    Paxillin; Paxillin family
    cd09336
    Location:412464
    LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family
  8. XM_006719538.1XP_006719601.1  

    Conserved Domains (5) summary
    cd09338
    Location:633685
    LIM3_Paxillin_like; The third LIM domain of the paxillin like protein family
    cd09407
    Location:574625
    LIM2_Paxillin; The second LIM domain of paxillin
    cd09411
    Location:692743
    LIM4_Paxillin; The fourth LIM domain of Paxillin
    pfam03535
    Location:60259
    Paxillin; Paxillin family
    cd09336
    Location:515567
    LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family
  9. XM_006719537.1XP_006719600.1  

    Conserved Domains (5) summary
    cd09338
    Location:825877
    LIM3_Paxillin_like; The third LIM domain of the paxillin like protein family
    cd09407
    Location:766817
    LIM2_Paxillin; The second LIM domain of paxillin
    cd09411
    Location:884935
    LIM4_Paxillin; The fourth LIM domain of Paxillin
    pfam03535
    Location:60259
    Paxillin; Paxillin family
    cd09336
    Location:707759
    LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family
  10. XM_005253910.1XP_005253967.1  

    Conserved Domains (5) summary
    cd09338
    Location:9721024
    LIM3_Paxillin_like; The third LIM domain of the paxillin like protein family
    cd09407
    Location:913964
    LIM2_Paxillin; The second LIM domain of paxillin
    cd09411
    Location:10311082
    LIM4_Paxillin; The fourth LIM domain of Paxillin
    pfam03535
    Location:60259
    Paxillin; Paxillin family
    cd09336
    Location:854906
    LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family
  11. XM_006719531.1XP_006719594.1  

    Conserved Domains (5) summary
    cd09338
    Location:10201072
    LIM3_Paxillin_like; The third LIM domain of the paxillin like protein family
    cd09407
    Location:9611012
    LIM2_Paxillin; The second LIM domain of paxillin
    cd09411
    Location:10791130
    LIM4_Paxillin; The fourth LIM domain of Paxillin
    pfam03535
    Location:60259
    Paxillin; Paxillin family
    cd09336
    Location:902954
    LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family
  12. XM_006719534.1XP_006719597.1  

    See proteins identical to XP_006719597.1

    Conserved Domains (5) summary
    cd09338
    Location:881933
    LIM3_Paxillin_like; The third LIM domain of the paxillin like protein family
    cd09407
    Location:822873
    LIM2_Paxillin; The second LIM domain of paxillin
    cd09411
    Location:940991
    LIM4_Paxillin; The fourth LIM domain of Paxillin
    pfam03535
    Location:1120
    Paxillin; Paxillin family
    cd09336
    Location:763815
    LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family
  13. XM_006719536.1XP_006719599.1  

    See proteins identical to XP_006719599.1

    Conserved Domains (5) summary
    cd09338
    Location:881933
    LIM3_Paxillin_like; The third LIM domain of the paxillin like protein family
    cd09407
    Location:822873
    LIM2_Paxillin; The second LIM domain of paxillin
    cd09411
    Location:940991
    LIM4_Paxillin; The fourth LIM domain of Paxillin
    pfam03535
    Location:1120
    Paxillin; Paxillin family
    cd09336
    Location:763815
    LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family
  14. XM_006719535.1XP_006719598.1  

    See proteins identical to XP_006719598.1

    Conserved Domains (5) summary
    cd09338
    Location:881933
    LIM3_Paxillin_like; The third LIM domain of the paxillin like protein family
    cd09407
    Location:822873
    LIM2_Paxillin; The second LIM domain of paxillin
    cd09411
    Location:940991
    LIM4_Paxillin; The fourth LIM domain of Paxillin
    pfam03535
    Location:1120
    Paxillin; Paxillin family
    cd09336
    Location:763815
    LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family
  15. XM_005253917.1XP_005253974.1  

    Conserved Domains (3) summary
    cd09338
    Location:288340
    LIM3_Paxillin_like; The third LIM domain of the paxillin like protein family
    cd09336
    Location:170222
    LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family
    cl02475
    Location:229280
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
  16. XM_005253912.2XP_005253969.1  

    Conserved Domains (1) summary
    pfam03535
    Location:60259
    Paxillin; Paxillin family

RNA

  1. XR_243019.1 RNA Sequence

Alternate CHM1_1.1

Genomic

  1. NC_018923.2 

    Range
    120616253..120671571
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000144.1 

    Range
    117656442..117711723
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)