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    Bak1 BCL2-antagonist/killer 1 [ Mus musculus (house mouse) ]

    Gene ID: 12018, updated on 25-Jul-2015
    Official Symbol
    Bak1provided by MGI
    Official Full Name
    BCL2-antagonist/killer 1provided by MGI
    Primary source
    MGI:MGI:1097161
    See related
    Ensembl:ENSMUSG00000057789; Vega:OTTMUSG00000030987
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Bak; N-Bak; N-BAK1
    Orthologs
    See Bak1 in Epigenomics, MapViewer
    Location:
    17; 17 B
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    105 current GRCm38.p3 (GCF_000001635.23) 17 NC_000083.6 (27019812..27028839, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (27156757..27165571, complement)

    Chromosome 17 - NC_000083.6Genomic Context describing neighboring genes Neighboring gene synaptic Ras GTPase activating protein 1 homolog (rat) Neighboring gene microRNA 3083 Neighboring gene zinc finger and BTB domain containing 9 Neighboring gene gametogenetin binding protein 1 Neighboring gene inositol 1,4,5-triphosphate receptor 3 Neighboring gene uncharacterized LOC105246244 Neighboring gene microRNA 7677

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    BH domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    chaperone binding ISO
    Inferred from Sequence Orthology
    more info
     
    heat shock protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein heterodimerization activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein homodimerization activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    B cell apoptotic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    B cell homeostasis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    B cell homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    B cell negative selection IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    activation of cysteine-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    activation of cysteine-type endopeptidase activity involved in apoptotic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    activation of cysteine-type endopeptidase activity involved in apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    apoptotic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    apoptotic process involved in patterning of blood vessels IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    blood vessel remodeling IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to UV IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to UV ISO
    Inferred from Sequence Orthology
    more info
     
    cytolysis ISO
    Inferred from Sequence Orthology
    more info
     
    establishment or maintenance of transmembrane electrochemical gradient ISO
    Inferred from Sequence Orthology
    more info
     
    extrinsic apoptotic signaling pathway in absence of ligand IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    fibroblast apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    homeostasis of number of cells IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    intrinsic apoptotic signaling pathway in response to DNA damage IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    intrinsic apoptotic signaling pathway in response to DNA damage IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    leukocyte homeostasis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    limb morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    mitochondrial fusion IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    myeloid cell homeostasis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of endoplasmic reticulum calcium ion concentration IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of peptidyl-serine phosphorylation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of calcium ion transport into cytosol IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of endoplasmic reticulum unfolded protein response ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of proteolysis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of release of cytochrome c from mitochondria ISO
    Inferred from Sequence Orthology
    more info
     
    post-embryonic camera-type eye morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of cell cycle IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of mitochondrial membrane permeability ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of mitochondrial membrane potential ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    release of cytochrome c from mitochondria IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    release of cytochrome c from mitochondria ISO
    Inferred from Sequence Orthology
    more info
     
    response to fungus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to gamma radiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to mycotoxin IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    thymocyte apoptotic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    vagina development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    cell IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endoplasmic reticulum IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of mitochondrial outer membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    intracellular IDA
    Inferred from Direct Assay
    more info
    PubMed 
    intracellular IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    membrane ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrial membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrial outer membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    pore complex ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    bcl-2 homologous antagonist/killer
    Names
    Bcl2 homologous antagonist/killer
    apoptosis regulator BAK

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007523.2NP_031549.2  bcl-2 homologous antagonist/killer

      See identical proteins and their annotated locations for NP_031549.2

      Status: VALIDATED

      Source sequence(s)
      AC132404, AW045927, BY197389, CX564692
      Consensus CDS
      CCDS28558.1
      UniProtKB/Swiss-Prot
      O08734
      Related
      ENSMUSP00000077757, OTTMUSP00000040454, ENSMUST00000078691, OTTMUST00000076752
      Conserved Domains (1) summary
      cd06845
      Location:27181
      Bcl-2_like; Apoptosis regulator proteins of the Bcl-2 family, named after B-cell lymphoma 2. This alignment model spans what have been described as Bcl-2 homology regions BH1, BH2, BH3, and BH4. Many members of this family have an additional C-terminal transmembrane ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p3 C57BL/6J

    Genomic

    1. NC_000083.6 Reference GRCm38.p3 C57BL/6J

      Range
      27019812..27028839
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_385266.2 RNA Sequence

    Alternate Mm_Celera

    Genomic

    1. AC_000039.1 Alternate Mm_Celera

      Range
      27556267..27565056
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)