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TRPA1 transient receptor potential cation channel, subfamily A, member 1 [ Homo sapiens (human) ]

Gene ID: 8989, updated on 21-Jul-2014
Official Symbol
TRPA1provided by HGNC
Official Full Name
transient receptor potential cation channel, subfamily A, member 1provided by HGNC
Primary source
HGNC:497
See related
Ensembl:ENSG00000104321; HPRD:09208; MIM:604775; Vega:OTTHUMG00000164516
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FEPS; ANKTM1
Summary
The structure of the protein encoded by this gene is highly related to both the protein ankyrin and transmembrane proteins. The specific function of this protein has not yet been determined; however, studies indicate the function may involve a role in signal transduction and growth control. [provided by RefSeq, Jul 2008]
See TRPA1 in Epigenomics, MapViewer
Location:
8q13
Exon count:
27
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 8 NC_000008.11 (72021251..72075584, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (72933486..72987819, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100132891 Neighboring gene musculin Neighboring gene ribosomal protein S20 pseudogene 20 Neighboring gene transient receptor potential cation channel, subfamily A, member 1 pseudogene Neighboring gene RNA, 5S ribosomal pseudogene 271

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Inflammatory mediator regulation of TRP channels, organism-specific biosystem (from KEGG)
    Inflammatory mediator regulation of TRP channels, organism-specific biosystemThe TRP channels that exhibit a unique response to temperature have been given the name thermo-TRPs. Among all thermo- TRP channels, TRPV1-4, TRPM8, and TRPA1 are expressed in subsets of nociceptive...
  • Inflammatory mediator regulation of TRP channels, conserved biosystem (from KEGG)
    Inflammatory mediator regulation of TRP channels, conserved biosystemThe TRP channels that exhibit a unique response to temperature have been given the name thermo-TRPs. Among all thermo- TRP channels, TRPV1-4, TRPM8, and TRPA1 are expressed in subsets of nociceptive...
  • Ion channel transport, organism-specific biosystem (from REACTOME)
    Ion channel transport, organism-specific biosystemIon channels mediate the flow of ions across the plasma membrane of cells. They are integral membrane proteins, typically a multimer of proteins, which, when arranged in the membrane, create a pore f...
  • Stimuli-sensing channels, organism-specific biosystem (from REACTOME)
    Stimuli-sensing channels, organism-specific biosystemIon channels that mediate sensations such as pain, warmth, cold, taste pressure and vision. Channels that mediate these sensations include acid-sensing ion channels (ASICs) (Wang & Xu 2011, Qadri et ...
  • TRP channels, organism-specific biosystem (from REACTOME)
    TRP channels, organism-specific biosystemTransient receptor potential (TRP) channel proteins were first discovered in Drosophila melanogaster and have many homologues in other species including humans. TRPs form cationic channels that can ...
  • Transmembrane transport of small molecules, organism-specific biosystem (from REACTOME)
    Transmembrane transport of small molecules, organism-specific biosystem
    Transmembrane transport of small molecules
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
calcium channel activity IEA
Inferred from Electronic Annotation
more info
 
channel activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
calcium ion transmembrane transport TAS
Traceable Author Statement
more info
 
detection of chemical stimulus involved in sensory perception of pain IEA
Inferred from Electronic Annotation
more info
 
detection of mechanical stimulus involved in sensory perception of pain IEA
Inferred from Electronic Annotation
more info
 
ion transmembrane transport TAS
Traceable Author Statement
more info
 
ion transport TAS
Traceable Author Statement
more info
PubMed 
response to cold IEA
Inferred from Electronic Annotation
more info
 
response to drug IEA
Inferred from Electronic Annotation
more info
 
response to hydrogen peroxide IEA
Inferred from Electronic Annotation
more info
 
response to pain IEA
Inferred from Electronic Annotation
more info
 
thermoception IEA
Inferred from Electronic Annotation
more info
 
transmembrane transport TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
stereocilium bundle IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
transient receptor potential cation channel subfamily A member 1
Names
transient receptor potential cation channel subfamily A member 1
transformation-sensitive protein p120
ankyrin-like with transmembrane domains 1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033890.1 

    Range
    5001..59334
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_007332.2NP_015628.2  transient receptor potential cation channel subfamily A member 1

    See proteins identical to NP_015628.2

    Status: REVIEWED

    Source sequence(s)
    AC016057, AC022867
    Consensus CDS
    CCDS34908.1
    UniProtKB/Swiss-Prot
    O75762
    Related
    ENSP00000262209, OTTHUMP00000226879, ENST00000262209, OTTHUMT00000379079
    Conserved Domains (4) summary
    cd00204
    Location:95218
    Blast Score: 318
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam00520
    Location:796959
    Blast Score: 178
    Ion_trans; Ion transport protein
    pfam12796
    Location:486577
    Blast Score: 213
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:274329
    Blast Score: 107
    Ank_4; Ankyrin repeats (many copies)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000008.11 

    Range
    72021251..72075584
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000140.1 

    Range
    68428222..68482529
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018919.2 

    Range
    72986840..73041189
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)