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    Mtor mechanistic target of rapamycin [ Rattus norvegicus (Norway rat) ]

    Gene ID: 56718, updated on 13-Jun-2016
    Official Symbol
    Mtorprovided by RGD
    Official Full Name
    mechanistic target of rapamycinprovided by RGD
    Primary source
    RGD:68371
    See related
    Ensembl:ENSRNOG00000009615
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Frap1; RAFT1
    Summary
    binds the complex formed by the immunosuppressive drug rapamycin and its receptor FKBP12; may play a role in the cell cycle G1 to S transition [RGD, Feb 2006]
    Annotation information
    Annotation category: partial on reference assembly
    Orthologs
    Location:
    5q36
    Exon count:
    58
    Annotation release Status Assembly Chr Location
    105 current Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (165263813..165373967)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 5 NC_005104.3 (168920414..169030568)

    Chromosome 5 - NC_005104.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102551951 Neighboring gene UbiA prenyltransferase domain containing 1 Neighboring gene angiopoietin-related protein 7-like Neighboring gene 40S ribosomal protein S2-like Neighboring gene exosome component 10 Neighboring gene spermidine synthase

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    RNA polymerase III type 1 promoter DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    RNA polymerase III type 1 promoter DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    RNA polymerase III type 2 promoter DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    RNA polymerase III type 2 promoter DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    RNA polymerase III type 3 promoter DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    RNA polymerase III type 3 promoter DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    TFIIIC-class transcription factor binding IEA
    Inferred from Electronic Annotation
    more info
     
    TFIIIC-class transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    macromolecular complex binding IEA
    Inferred from Electronic Annotation
    more info
     
    phosphoprotein binding IEA
    Inferred from Electronic Annotation
    more info
     
    phosphoprotein binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein domain specific binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein serine/threonine kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    ribosome binding IEA
    Inferred from Electronic Annotation
    more info
     
    ribosome binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    'de novo' pyrimidine nucleobase biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    'de novo' pyrimidine nucleobase biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    DNA repair IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    TOR signaling IEA
    Inferred from Electronic Annotation
    more info
     
    TOR signaling ISO
    Inferred from Sequence Orthology
    more info
     
    brain development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cardiac cell development ISO
    Inferred from Sequence Orthology
    more info
     
    cardiac muscle cell development IEA
    Inferred from Electronic Annotation
    more info
     
    cardiac muscle cell development ISO
    Inferred from Sequence Orthology
    more info
     
    cardiac muscle contraction IEA
    Inferred from Electronic Annotation
    more info
     
    cardiac muscle contraction ISO
    Inferred from Sequence Orthology
    more info
     
    cardiac muscle tissue development ISO
    Inferred from Sequence Orthology
    more info
     
    cell aging IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cell growth IEA
    Inferred from Electronic Annotation
    more info
     
    cell growth ISO
    Inferred from Sequence Orthology
    more info
     
    cell projection organization IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    cell projection organization ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to hypoxia ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to hypoxia ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cellular response to nutrient levels ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to nutrient levels ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    energy reserve metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    energy reserve metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    germ cell development IEA
    Inferred from Electronic Annotation
    more info
     
    germ cell development ISO
    Inferred from Sequence Orthology
    more info
     
    heart morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    heart morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    heart valve morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    heart valve morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    long-term memory IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mRNA stabilization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    maternal process involved in female pregnancy IDA
    Inferred from Direct Assay
    more info
    PubMed 
    multicellular organism growth IEA
    Inferred from Electronic Annotation
    more info
     
    multicellular organism growth ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of NFAT protein import into nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of NFAT protein import into nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of autophagy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of autophagy ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of autophagy ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of cell size IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of cell size ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cholangiocyte apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of iodide transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of macroautophagy IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of macroautophagy ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of muscle atrophy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of protein ubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    peptidyl-serine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    peptidyl-threonine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    peptidyl-threonine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of actin filament polymerization IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of actin filament polymerization ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell death IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cell growth involved in cardiac muscle cell development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cholangiocyte proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of dendritic spine development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of eating behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of endothelial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of glial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of granulosa cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of lamellipodium assembly IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of lamellipodium assembly ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of lipid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of lipid biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of myotube differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of myotube differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of neurogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of neuron death IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of neuron maturation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of neuron projection development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of nitric oxide biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of oligodendrocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of oligodendrocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of peptidyl-tyrosine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of peptidyl-tyrosine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein kinase B signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of sensory perception of pain IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of skeletal muscle hypertrophy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of smooth muscle cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of stress fiber assembly IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of stress fiber assembly ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription from RNA polymerase III promoter IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of transcription from RNA polymerase III promoter ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of translation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of translation ISO
    Inferred from Sequence Orthology
    more info
     
    post-embryonic development IEA
    Inferred from Electronic Annotation
    more info
     
    post-embryonic development ISO
    Inferred from Sequence Orthology
    more info
     
    protein autophosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of brown fat cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of carbohydrate metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of carbohydrate metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of carbohydrate utilization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of carbohydrate utilization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of fatty acid beta-oxidation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of fatty acid beta-oxidation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of glycogen biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of glycogen biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of membrane permeability IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of membrane permeability ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of myelination IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of myelination ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of osteoclast differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of osteoclast differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of protein kinase B signaling ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of response to food IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of response to food IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to amino acid IEA
    Inferred from Electronic Annotation
    more info
     
    response to amino acid ISO
    Inferred from Sequence Orthology
    more info
     
    response to cocaine IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to insulin IEA
    Inferred from Electronic Annotation
    more info
     
    response to insulin ISO
    Inferred from Sequence Orthology
    more info
     
    response to morphine IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ruffle organization IEA
    Inferred from Electronic Annotation
    more info
     
    ruffle organization ISO
    Inferred from Sequence Orthology
    more info
     
    social behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    spinal cord development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    visual learning IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    voluntary musculoskeletal movement IEA
    Inferred from Electronic Annotation
    more info
     
    voluntary musculoskeletal movement ISO
    Inferred from Sequence Orthology
    more info
     
    wound healing IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    Component Evidence Code Pubs
    Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
     
    colocalizes_with PML body ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with PML body ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    TORC1 complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    TORC1 complex ISO
    Inferred from Sequence Orthology
    more info
     
    TORC2 complex IEA
    Inferred from Electronic Annotation
    more info
     
    TORC2 complex ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    endomembrane system ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    lysosomal membrane IEA
    Inferred from Electronic Annotation
    more info
     
    lysosomal membrane ISO
    Inferred from Sequence Orthology
    more info
     
    lysosome ISO
    Inferred from Sequence Orthology
    more info
     
    lysosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    macromolecular complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
     
    colocalizes_with neuronal cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    serine/threonine-protein kinase mTOR
    Names
    FK506 binding protein 12-rapamycin associated protein 1
    FK506-binding protein 12-rapamycin complex-associated protein 1
    FKBP12-rapamycin complex-associated protein
    RAPT1
    mammalian target of rapamycin
    mechanistic target of rapamycin (serine/threonine kinase)
    rapamycin and FKBP12 target-1 protein
    rapamycin target protein 1
    NP_063971.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019906.1NP_063971.1  serine/threonine-protein kinase mTOR

      See identical proteins and their annotated locations for NP_063971.1

      Status: PROVISIONAL

      Source sequence(s)
      U11681
      UniProtKB/Swiss-Prot
      P42346
      Related
      ENSRNOP00000014167, ENSRNOT00000014167
      Conserved Domains (6) summary
      COG5032
      Location:3632549
      TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
      pfam02260
      Location:25192549
      FATC; FATC domain
      pfam08771
      Location:20152114
      Rapamycin_bind; Rapamycin binding domain
      pfam11865
      Location:8541024
      DUF3385; Domain of unknown function (DUF3385)
      pfam13513
      Location:748805
      HEAT_EZ; HEAT-like repeat
      cd05169
      Location:21532431
      PIKKc_TOR; Catalytic domain of Target of Rapamycin

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 105 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005104.4 Reference Rnor_6.0 Primary Assembly

      Range
      165263813..165373967
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Rn_Celera

    Genomic

    1. AC_000073.1 Alternate Rn_Celera

      Range
      157161454..157270899
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)