Display Settings:

Format

Send to:

Choose Destination

AGR2 anterior gradient 2 [ Homo sapiens (human) ]

Gene ID: 10551, updated on 18-Aug-2014
Official Symbol
AGR2provided by HGNC
Official Full Name
anterior gradient 2provided by HGNC
Primary source
HGNC:328
Locus tag
UNQ515/PRO1030
See related
Ensembl:ENSG00000106541; HPRD:05896; MIM:606358; Vega:OTTHUMG00000023446
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AG2; GOB-4; HAG-2; XAG-2; PDIA17; HEL-S-116
See AGR2 in Epigenomics, MapViewer
Location:
7p21.3
Exon count:
8
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 7 NC_000007.14 (16791813..16805114, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (16831437..16844738, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene basic leucine zipper and W2 domains 2 Neighboring gene uncharacterized LOC101927585 Neighboring gene tetraspanin 13 Neighboring gene Rho GTPase activating protein 20 pseudogene Neighboring gene RAD17 homolog (S. pombe) pseudogene 1 Neighboring gene anterior gradient 3

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Exploring genome-wide - dietary heme iron intake interactions and the risk of type 2 diabetes.
NHGRI GWA Catalog
Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan.
NHGRI GWA Catalog
Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
NHGRI GWA Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
dystroglycan binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
lung goblet cell differentiation IEA
Inferred from Electronic Annotation
more info
 
mucus secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
mitochondrion IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
anterior gradient protein 2 homolog
Names
anterior gradient protein 2 homolog
AG-2
HPC8
anterior gradient homolog 2
secreted cement gland homolog
epididymis secretory protein Li 116
secreted cement gland protein XAG-2 homolog
protein disulfide isomerase family A, member 17

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006408.3NP_006399.1  anterior gradient protein 2 homolog precursor

    See proteins identical to NP_006399.1

    Status: VALIDATED

    Source sequence(s)
    AF088867, BF680655
    Consensus CDS
    CCDS5364.1
    UniProtKB/Swiss-Prot
    O95994
    UniProtKB/TrEMBL
    Q4JM46
    Conserved Domains (1) summary
    cd02960
    Location:47175
    Blast Score: 678
    AGR; Anterior Gradient (AGR) family; members of this family are similar to secreted proteins encoded by the cement gland-specific genes XAG-1 and XAG-2, expressed in the anterior region of dorsal ectoderm of Xenopus. They are implicated in the formation of ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000007.14 

    Range
    16791813..16805114
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005249581.2XP_005249638.1  

    See proteins identical to XP_005249638.1

    UniProtKB/Swiss-Prot
    O95994
    UniProtKB/TrEMBL
    Q4JM46
    Related
    ENSP00000391490, OTTHUMP00000116014
    Conserved Domains (1) summary
    cd02960
    Location:47175
    Blast Score: 678
    AGR; Anterior Gradient (AGR) family; members of this family are similar to secreted proteins encoded by the cement gland-specific genes XAG-1 and XAG-2, expressed in the anterior region of dorsal ectoderm of Xenopus. They are implicated in the formation of ...

Alternate HuRef

Genomic

  1. AC_000139.1 

    Range
    16719359..16731797
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018918.2 

    Range
    16833176..16845615
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)