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Grn granulin [ Mus musculus (house mouse) ]

Gene ID: 14824, updated on 19-Sep-2014
Official Symbol
Grnprovided by MGI
Official Full Name
granulinprovided by MGI
Primary source
MGI:MGI:95832
Locus tag
RP23-226P4.4
See related
Ensembl:ENSMUSG00000034708; Vega:OTTMUSG00000002816
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pgrn; epithelin
Location:
11 D; 11 66.29 cM
Exon count:
13
Annotation release Status Assembly Chr Location
104 current GRCm38.p2 (GCF_000001635.22) 11 NC_000077.6 (102430322..102436809)

Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene RUN domain containing 3A Neighboring gene solute carrier family 25, member 39 Neighboring gene microRNA mir-6930 Neighboring gene family with sequence similarity 171, member A2 Neighboring gene integrin alpha 2b

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
cytokine activity IEA
Inferred from Electronic Annotation
more info
 
poly(A) RNA binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
blastocyst hatching IDA
Inferred from Direct Assay
more info
PubMed 
chondrocyte proliferation ISO
Inferred from Sequence Orthology
more info
 
embryo implantation IDA
Inferred from Direct Assay
more info
PubMed 
male mating behavior ISO
Inferred from Sequence Orthology
more info
 
neural precursor cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of dendritic spine development ISO
Inferred from Sequence Orthology
more info
 
positive regulation of epithelial cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
 
response to estradiol ISO
Inferred from Sequence Orthology
more info
 
synaptic vesicle endocytosis ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cell surface ISO
Inferred from Sequence Orthology
more info
 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
extracellular vesicular exosome ISO
Inferred from Sequence Orthology
more info
 
intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
granulins
Names
granulins
PEPI
PCDGF
progranulin
acrogranulin
proepithelin
PC cell-derived growth factor

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008175.4NP_032201.2  granulins precursor

    See proteins identical to NP_032201.2

    Status: VALIDATED

    Source sequence(s)
    AK018744, AK152705, AW456643, BY275129
    Consensus CDS
    CCDS48943.1
    UniProtKB/TrEMBL
    Q3U9N4
    UniProtKB/TrEMBL
    Q9D2V3
    Related
    ENSMUSP00000046340, OTTMUSP00000002716, ENSMUST00000049460, OTTMUST00000005699
    Conserved Domains (1) summary
    smart00277
    Location:296346
    GRAN; Granulin

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p2 C57BL/6J

Genomic

  1. NC_000077.6 

    Range
    102430322..102436809
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. AC_000033.1 

    Range
    114140482..114146970
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)