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    ADORA2A adenosine A2a receptor [ Homo sapiens (human) ]

    Gene ID: 135, updated on 28-Jun-2015
    Official Symbol
    ADORA2Aprovided by HGNC
    Official Full Name
    adenosine A2a receptorprovided by HGNC
    Primary source
    HGNC:HGNC:263
    See related
    Ensembl:ENSG00000128271; HPRD:00043; MIM:102776; Vega:OTTHUMG00000150761
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    A2aR; RDC8; ADORA2
    Summary
    This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor (GPCR) superfamily, which is subdivided into classes and subtypes. The receptors are seven-pass transmembrane proteins that respond to extracellular cues and activate intracellular signal transduction pathways. This protein, an adenosine receptor of A2A subtype, uses adenosine as the preferred endogenous agonist and preferentially interacts with the G(s) and G(olf) family of G proteins to increase intracellular cAMP levels. It plays an important role in many biological functions, such as cardiac rhythm and circulation, cerebral and renal blood flow, immune function, pain regulation, and sleep. It has been implicated in pathophysiological conditions such as inflammatory diseases and neurodegenerative disorders. Alternative splicing results in multiple transcript variants. A read-through transcript composed of the upstream SPECC1L (sperm antigen with calponin homology and coiled-coil domains 1-like) and ADORA2A (adenosine A2a receptor) gene sequence has been identified, but it is thought to be non-coding. [provided by RefSeq, Jun 2013]
    Orthologs
    See ADORA2A in Epigenomics, MapViewer
    Location:
    22q11.23
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 22 NC_000022.11 (24423597..24442360)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (24819565..24838328)

    Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene SPECC1L-ADORA2A readthrough (NMD candidate) Neighboring gene ribosomal protein S10 pseudogene 29 Neighboring gene sperm antigen with calponin homology and coiled-coil domains 1-like Neighboring gene uncharacterized LOC105372960 Neighboring gene ADORA2A antisense RNA 1 Neighboring gene ureidopropionase, beta Neighboring gene guanylyl cyclase domain containing 1 Neighboring gene small nuclear ribonucleoprotein D3 polypeptide 18kDa

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat Activation of adenosine A2a receptor with CGS 21680 inhibits Tat-induced increases of intracellular calcium and this inhibition is dependent on protein phosphatase activity in monocytes PubMed

    Go to the HIV-1, Human Interaction Database

    • Activation of TRKA receptors, organism-specific biosystem (from REACTOME)
      Activation of TRKA receptors, organism-specific biosystemTrk receptors can either be activated by neurotrophins or by two G-protein-coupled receptors (GPCRs) although the biological relevance of GPCRs remains to be shown.
    • Adenosine P1 receptors, organism-specific biosystem (from REACTOME)
      Adenosine P1 receptors, organism-specific biosystemThe adenosine receptors (P1 receptors) are a class of purinergic receptors, G-protein coupled receptors with adenosine as their endogenous ligand.In humans, there are four adenosine receptors. Each i...
    • Alcoholism, organism-specific biosystem (from KEGG)
      Alcoholism, organism-specific biosystemAlcoholism, also called dependence on alcohol (ethanol), is a chronic relapsing disorder that is progressive and has serious detrimental health outcomes. As one of the primary mediators of the reward...
    • Alcoholism, conserved biosystem (from KEGG)
      Alcoholism, conserved biosystemAlcoholism, also called dependence on alcohol (ethanol), is a chronic relapsing disorder that is progressive and has serious detrimental health outcomes. As one of the primary mediators of the reward...
    • Calcium signaling pathway, organism-specific biosystem (from KEGG)
      Calcium signaling pathway, organism-specific biosystemCa2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this...
    • Calcium signaling pathway, conserved biosystem (from KEGG)
      Calcium signaling pathway, conserved biosystemCa2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this...
    • Class A/1 (Rhodopsin-like receptors), organism-specific biosystem (from REACTOME)
      Class A/1 (Rhodopsin-like receptors), organism-specific biosystemRhodopsin-like receptors (class A/1) are the largest group of GPCRs and are the best studied group from a functional and structural point of view. They show great diversity at the sequence level and ...
    • G alpha (s) signalling events, organism-specific biosystem (from REACTOME)
      G alpha (s) signalling events, organism-specific biosystemThe general function of the G alpha (s) subunit (Gs) is to activate adenylate cyclase, which in turn produces cAMP, leading to the activation of cAMP-dependent protein kinases (often referred to col...
    • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
      GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
    • GPCR ligand binding, organism-specific biosystem (from REACTOME)
      GPCR ligand binding, organism-specific biosystemThere are more than 800 G-protein coupled receptor (GPCRs) in the human genome, making it the largest receptor superfamily. GPCRs are also the largest class of drug targets, involved in virtually all...
    • GPCRs, Class A Rhodopsin-like, organism-specific biosystem (from WikiPathways)
      GPCRs, Class A Rhodopsin-like, organism-specific biosystemThis pathway was created using the GPCRDB (Horn et al., 1998), http://www.cmbi.kun.nl/7tm/. The groupings are based on the GPCR phylogenetic tree available from the GPCRDB and the training sets used ...
    • GPCRs, Other, organism-specific biosystem (from WikiPathways)
      GPCRs, Other, organism-specific biosystemThis pathway was created using the GPCRDB (Horn et al., 1998), http://www.cmbi.kun.nl/7tm/. The groupings are based on the GPCR phylogenetic tree available from the GPCRDB and the training sets used ...
    • HIF-2-alpha transcription factor network, organism-specific biosystem (from Pathway Interaction Database)
      HIF-2-alpha transcription factor network, organism-specific biosystem
      HIF-2-alpha transcription factor network
    • Monoamine Transport, organism-specific biosystem (from WikiPathways)
      Monoamine Transport, organism-specific biosystem
      Monoamine Transport
    • NGF signalling via TRKA from the plasma membrane, organism-specific biosystem (from REACTOME)
      NGF signalling via TRKA from the plasma membrane, organism-specific biosystemTrk receptors signal from the plasma membrane and from intracellular membranes, particularly from early endosomes. Signalling from the plasma membrane is fast but transient; signalling from endosomes...
    • NGF-independant TRKA activation, organism-specific biosystem (from REACTOME)
      NGF-independant TRKA activation, organism-specific biosystemTRK receptors can also be activated by at least two G-protein-coupled receptors (GPCR), the adenosine A2a receptor and the PACAP type I receptor, without involvement of neurotrophins. Activity of bo...
    • Neuroactive ligand-receptor interaction, organism-specific biosystem (from KEGG)
      Neuroactive ligand-receptor interaction, organism-specific biosystem
      Neuroactive ligand-receptor interaction
    • Neuroactive ligand-receptor interaction, conserved biosystem (from KEGG)
      Neuroactive ligand-receptor interaction, conserved biosystem
      Neuroactive ligand-receptor interaction
    • Nucleotide GPCRs, organism-specific biosystem (from WikiPathways)
      Nucleotide GPCRs, organism-specific biosystem
      Nucleotide GPCRs
    • Nucleotide-like (purinergic) receptors, organism-specific biosystem (from REACTOME)
      Nucleotide-like (purinergic) receptors, organism-specific biosystemPurinergic receptors (Burnstock G, 2006; Abbracchio MP et al, 2009) are a family of newly characterized plasma membrane molecules involved in several cellular functions such as vascular reactivity, a...
    • Parkinson's disease, organism-specific biosystem (from KEGG)
      Parkinson's disease, organism-specific biosystemParkinson's disease (PD) is a progressive neurodegenerative movement disorder that results primarily from the death of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNc). Mutations...
    • Rap1 signaling pathway, organism-specific biosystem (from KEGG)
      Rap1 signaling pathway, organism-specific biosystemRap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an ac...
    • Rap1 signaling pathway, conserved biosystem (from KEGG)
      Rap1 signaling pathway, conserved biosystemRap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an ac...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by GPCR, organism-specific biosystem (from REACTOME)
      Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...
    • Signalling by NGF, organism-specific biosystem (from REACTOME)
      Signalling by NGF, organism-specific biosystemNeurotrophins (NGF, BDNF, NT-3, NT-4/5) play pivotal roles in survival, differentiation, and plasticity of neurons in the peripheral and central nervous system. They are produced, and secreted in mi...
    • Vascular smooth muscle contraction, organism-specific biosystem (from KEGG)
      Vascular smooth muscle contraction, organism-specific biosystemThe vascular smooth muscle cell (VSMC) is a highly specialized cell whose principal function is contraction. On contraction, VSMCs shorten, thereby decreasing the diameter of a blood vessel to regula...
    • Vascular smooth muscle contraction, conserved biosystem (from KEGG)
      Vascular smooth muscle contraction, conserved biosystemThe vascular smooth muscle cell (VSMC) is a highly specialized cell whose principal function is contraction. On contraction, VSMCs shorten, thereby decreasing the diameter of a blood vessel to regula...
    • cAMP signaling pathway, organism-specific biosystem (from KEGG)
      cAMP signaling pathway, organism-specific biosystemcAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands incl...
    • cAMP signaling pathway, conserved biosystem (from KEGG)
      cAMP signaling pathway, conserved biosystemcAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands incl...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Readthrough SPECC1L-ADORA2A

    Readthrough gene: SPECC1L-ADORA2A, Included gene: SPECC1L

    Homology

    Clone Names

    • FLJ61179

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    G-protein coupled adenosine receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enzyme binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    integral component of plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    Preferred Names
    adenosine receptor A2a
    Names
    adenosine receptor A2a
    adenosine receptor subtype A2a

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_000675.5NP_000666.2  adenosine receptor A2a

      See identical proteins and their annotated locations for NP_000666.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants, 1, 2, 3, 4, and 5 encode the same protein.
      Source sequence(s)
      AK123058, BC013780, CA307692, DA942067
      Consensus CDS
      CCDS13826.1
      UniProtKB/TrEMBL
      B3KVQ4
      UniProtKB/Swiss-Prot
      P29274
      UniProtKB/TrEMBL
      X5DNB4
      Related
      ENSP00000336630, OTTHUMP00000198454, ENST00000337539, OTTHUMT00000319971
      Conserved Domains (2) summary
      pfam00001
      Location:29288
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:17302
      7tm_4; Olfactory receptor
    2. NM_001278497.1NP_001265426.1  adenosine receptor A2a

      See identical proteins and their annotated locations for NP_001265426.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants, 1, 2, 3, 4, and 5 encode the same protein.
      Source sequence(s)
      AK289871, BG686029, CA307692, CN408252, HY249059
      Consensus CDS
      CCDS13826.1
      UniProtKB/TrEMBL
      A8K1F6
      UniProtKB/Swiss-Prot
      P29274
      UniProtKB/TrEMBL
      X5DNB4
      Related
      ENSP00000480012, ENST00000610595
      Conserved Domains (2) summary
      pfam00001
      Location:29288
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:17302
      7tm_4; Olfactory receptor
    3. NM_001278498.1NP_001265427.1  adenosine receptor A2a

      See identical proteins and their annotated locations for NP_001265427.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants, 1, 2, 3, 4, and 5 encode the same protein.
      Source sequence(s)
      AK289871, BG686029, CA307692, CR456367, DA270141, HY249059
      Consensus CDS
      CCDS13826.1
      UniProtKB/TrEMBL
      A8K1F6
      UniProtKB/Swiss-Prot
      P29274
      UniProtKB/TrEMBL
      X5DNB4
      Related
      ENSP00000481552, ENST00000618076
      Conserved Domains (2) summary
      pfam00001
      Location:29288
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:17302
      7tm_4; Olfactory receptor
    4. NM_001278499.1NP_001265428.1  adenosine receptor A2a

      See identical proteins and their annotated locations for NP_001265428.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants, 1, 2, 3, 4, and 5 encode the same protein.
      Source sequence(s)
      BG686029, CA307692, CR456367, DA942067, HY249059
      Consensus CDS
      CCDS13826.1
      UniProtKB/Swiss-Prot
      P29274
      UniProtKB/TrEMBL
      X5DNB4
      Conserved Domains (2) summary
      pfam00001
      Location:29288
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:17302
      7tm_4; Olfactory receptor
    5. NM_001278500.1NP_001265429.1  adenosine receptor A2a

      See identical proteins and their annotated locations for NP_001265429.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants, 1, 2, 3, 4, and 5 encode the same protein.
      Source sequence(s)
      BG686029, CA307692, CR456367, DA781734, HY249059
      Consensus CDS
      CCDS13826.1
      UniProtKB/Swiss-Prot
      P29274
      UniProtKB/TrEMBL
      X5DNB4
      Related
      ENSP00000483102, ENST00000611543
      Conserved Domains (2) summary
      pfam00001
      Location:29288
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:17302
      7tm_4; Olfactory receptor

    RNA

    1. NR_103543.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) lacks an internal exon, compared to variant 1. This variant is represented as non-coding because it lacks a portion of the coding region, including the translational start codon, found in variant 1.
      Source sequence(s)
      BG686029, CA307692, DA687739, DA942067, HY102778, HY249059
    2. NR_103544.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) lacks an internal exon, compared to variant 1. This variant is represented as non-coding because it lacks a portion of the coding region, including the translational start codon, found in variant 1.
      Source sequence(s)
      BG686029, CA307692, DA687739, DA942067, DA983859, HY249059

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000022.11 Reference GRCh38.p2 Primary Assembly

      Range
      24423597..24442360
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018933.2 Alternate CHM1_1.1

      Range
      24778238..24796999
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)