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ZFP36L2 ZFP36 ring finger protein-like 2 [ Homo sapiens (human) ]

Gene ID: 678, updated on 6-Jul-2014
Official Symbol
ZFP36L2provided by HGNC
Official Full Name
ZFP36 ring finger protein-like 2provided by HGNC
Primary source
HGNC:1108
See related
Ensembl:ENSG00000152518; HPRD:18319; MIM:612053; Vega:OTTHUMG00000128642
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BRF2; ERF2; ERF-2; TIS11D; RNF162C
Summary
This gene is a member of the TIS11 family of early response genes. Family members are induced by various agonists such as the phorbol ester TPA and the polypeptide mitogen EGF. The encoded protein contains a distinguishing putative zinc finger domain with a repeating cys-his motif. This putative nuclear transcription factor most likely functions in regulating the response to growth factors. [provided by RefSeq, Jul 2008]
See ZFP36L2 in Epigenomics, MapViewer
Location:
2p22.3-p21
Exon count :
2
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 2 NC_000002.12 (43222402..43226606, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (43449541..43453745, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100506047 Neighboring gene uncharacterized LOC101929763 Neighboring gene long intergenic non-protein coding RNA 1126 Neighboring gene thyroid adenoma associated

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Genome-wide association study identifies susceptibility loci for polycystic ovary syndrome on chromosome 2p16.3, 2p21 and 9q33.3.
NHGRI GWA Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
AU-rich element binding IDA
Inferred from Direct Assay
more info
 
DNA binding IEA
Inferred from Electronic Annotation
more info
 
mRNA 3'-UTR AU-rich region binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
poly(A) RNA binding IDA
Inferred from Direct Assay
more info
 
sequence-specific DNA binding transcription factor activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
T cell differentiation in thymus IEA
Inferred from Electronic Annotation
more info
 
cell proliferation TAS
Traceable Author Statement
more info
PubMed 
definitive hemopoiesis ISS
Inferred from Sequence or Structural Similarity
more info
 
hemopoiesis ISS
Inferred from Sequence or Structural Similarity
more info
 
mRNA catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of stem cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IEA
Inferred from Electronic Annotation
more info
 
positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of mRNA stability IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription, DNA-templated TAS
Traceable Author Statement
more info
PubMed 
somatic stem cell division ISS
Inferred from Sequence or Structural Similarity
more info
 
somatic stem cell maintenance ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
Preferred Names
zinc finger protein 36, C3H1 type-like 2
Names
zinc finger protein 36, C3H1 type-like 2
ZFP36-like 2
EGF-response factor 2
butyrate response factor 2
zinc finger protein 36, C3H type-like 1
zinc finger protein 36, C3H type-like 2
zinc finger protein, C3H type, 36-like 2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006887.4NP_008818.3  zinc finger protein 36, C3H1 type-like 2

    See proteins identical to NP_008818.3

    Status: REVIEWED

    Source sequence(s)
    AC010883, N67537
    Consensus CDS
    CCDS1811.1
    UniProtKB/Swiss-Prot
    P47974
    Related
    ENSP00000282388, OTTHUMP00000158808, ENST00000282388, OTTHUMT00000250513
    Conserved Domains (2) summary
    pfam00642
    Location:192216
    Blast Score: 124
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    pfam04553
    Location:1130
    Blast Score: 212
    Tis11B_N; Tis11B like protein, N terminus

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000002.12 

    Range
    43222402..43226606
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000134.1 

    Range
    43184882..43189086
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018913.2 

    Range
    43378882..43383086
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

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