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Nlgn2 neuroligin 2 [ Mus musculus (house mouse) ]

Gene ID: 216856, updated on 4-May-2015
Official Symbol
Nlgn2provided by MGI
Official Full Name
neuroligin 2provided by MGI
Primary source
MGI:MGI:2681835
See related
Ensembl:ENSMUSG00000051790; Vega:OTTMUSG00000005998
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
NL2
Orthologs
See Nlgn2 in MapViewer
Location:
11; 11 B3
Exon count:
8
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 11 NC_000077.6 (69823123..69838377, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (69636625..69648351, complement)

Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4933402P03 gene Neighboring gene sperm maturation 1 Neighboring gene transmembrane protein 256 Neighboring gene phospholipid scramblase 3 Neighboring gene tyrosine kinase, non-receptor, 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Cell adhesion molecules (CAMs), organism-specific biosystem (from KEGG)
    Cell adhesion molecules (CAMs), organism-specific biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
  • Cell adhesion molecules (CAMs), conserved biosystem (from KEGG)
    Cell adhesion molecules (CAMs), conserved biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
Products Interactant Other Gene Complex Source Pubs Description

Homology

Clone Names

  • MGC67386

Gene Ontology Provided by MGI

Function Evidence Code Pubs
carboxylic ester hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
cell adhesion molecule binding IPI
Inferred from Physical Interaction
more info
PubMed 
neurexin family protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
cell adhesion IEA
Inferred from Electronic Annotation
more info
 
gephyrin clustering involved in postsynaptic density assembly IDA
Inferred from Direct Assay
more info
PubMed 
insulin metabolic process ISO
Inferred from Sequence Orthology
more info
 
jump response ISO
Inferred from Sequence Orthology
more info
 
locomotory exploration behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
neuromuscular process controlling balance IMP
Inferred from Mutant Phenotype
more info
PubMed 
neuron cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
 
neuron cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of dendritic spine development ISO
Inferred from Sequence Orthology
more info
 
positive regulation of excitatory postsynaptic membrane potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of inhibitory postsynaptic membrane potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of inhibitory postsynaptic membrane potential ISO
Inferred from Sequence Orthology
more info
 
positive regulation of insulin secretion ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein localization to synapse ISO
Inferred from Sequence Orthology
more info
 
positive regulation of synapse assembly ISO
Inferred from Sequence Orthology
more info
 
positive regulation of synaptic transmission, GABAergic IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of synaptic transmission, glutamatergic IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of synaptic vesicle clustering IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of t-SNARE clustering ISO
Inferred from Sequence Orthology
more info
 
postsynaptic density protein 95 clustering IDA
Inferred from Direct Assay
more info
PubMed 
postsynaptic membrane assembly IDA
Inferred from Direct Assay
more info
PubMed 
presynaptic membrane assembly IDA
Inferred from Direct Assay
more info
PubMed 
presynaptic membrane assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
presynaptic membrane assembly ISO
Inferred from Sequence Orthology
more info
 
protein localization to synapse IDA
Inferred from Direct Assay
more info
PubMed 
regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of respiratory gaseous exchange by neurological system process IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of synaptic transmission IGI
Inferred from Genetic Interaction
more info
PubMed 
sensory perception of pain IMP
Inferred from Mutant Phenotype
more info
PubMed 
social behavior ISO
Inferred from Sequence Orthology
more info
 
synapse assembly IBA
Inferred from Biological aspect of Ancestor
more info
 
synapse assembly ISO
Inferred from Sequence Orthology
more info
 
synapse organization ISO
Inferred from Sequence Orthology
more info
 
terminal button organization ISO
Inferred from Sequence Orthology
more info
 
thigmotaxis ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cell junction IEA
Inferred from Electronic Annotation
more info
 
cell surface IBA
Inferred from Biological aspect of Ancestor
more info
 
cell surface ISO
Inferred from Sequence Orthology
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
dendritic shaft ISO
Inferred from Sequence Orthology
more info
 
excitatory synapse IC
Inferred by Curator
more info
PubMed 
excitatory synapse ISO
Inferred from Sequence Orthology
more info
 
inhibitory synapse IC
Inferred by Curator
more info
PubMed 
inhibitory synapse ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
integral component of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
postsynaptic membrane ISO
Inferred from Sequence Orthology
more info
 
ribbon synapse ISO
Inferred from Sequence Orthology
more info
 
synapse IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
neuroligin-2
Names
neuroligin-2
ortholog of human and rat neuroligin 2 NLGN2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_198862.2NP_942562.2  neuroligin-2 precursor

    See identical proteins and their annotated locations for NP_942562.2

    Status: VALIDATED

    Source sequence(s)
    AK173159, BC056478, BE952199
    Consensus CDS
    CCDS24914.1
    UniProtKB/Swiss-Prot
    Q69ZK9
    UniProtKB/TrEMBL
    Q6PHN2
    Related
    ENSMUSP00000053097, OTTMUSP00000040960, ENSMUST00000056484, OTTMUST00000077459
    Conserved Domains (2) summary
    COG0657
    Location:178268
    Aes; Esterase/lipase [Lipid metabolism]
    pfam00135
    Location:42601
    COesterase; Carboxylesterase family

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000077.6 Reference GRCm38.p3 C57BL/6J

    Range
    69823123..69838377
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006532902.2XP_006532965.1  

    Conserved Domains (2) summary
    COG0657
    Location:87251
    Aes; Esterase/lipase [Lipid metabolism]
    pfam00135
    Location:42584
    COesterase; Carboxylesterase family
  2. XM_006532901.1XP_006532964.1  

    See identical proteins and their annotated locations for XP_006532964.1

    UniProtKB/Swiss-Prot
    Q69ZK9
    Related
    ENSMUSP00000104274, OTTMUSP00000006214, ENSMUST00000108634, OTTMUST00000013425
    Conserved Domains (2) summary
    COG0657
    Location:178268
    Aes; Esterase/lipase [Lipid metabolism]
    pfam00135
    Location:42601
    COesterase; Carboxylesterase family
  3. XM_006532903.2XP_006532966.1  

    Conserved Domains (2) summary
    COG0657
    Location:61151
    Aes; Esterase/lipase [Lipid metabolism]
    pfam00135
    Location:19484
    COesterase; Carboxylesterase family

Alternate Mm_Celera

Genomic

  1. AC_000033.1 Alternate Mm_Celera

    Range
    77384083..77395807
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)