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TTK TTK protein kinase [ Homo sapiens (human) ]

Gene ID: 7272, updated on 23-Mar-2015
Official Symbol
TTKprovided by HGNC
Official Full Name
TTK protein kinaseprovided by HGNC
Primary source
HGNC:HGNC:12401
See related
Ensembl:ENSG00000112742; HPRD:04973; MIM:604092; Vega:OTTHUMG00000015088
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ESK; PYT; CT96; MPH1; MPS1; MPS1L1
Summary
This gene encodes a dual specificity protein kinase with the ability to phosphorylate tyrosine, serine and threonine. Associated with cell proliferation, this protein is essential for chromosome alignment at the centromere during mitosis and is required for centrosome duplication. It has been found to be a critical mitotic checkpoint protein for accurate segregation of chromosomes during mitosis. Tumorigenesis may occur when this protein fails to degrade and produces excess centrosomes resulting in aberrant mitotic spindles. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2009]
Orthologs
See TTK in MapViewer
Location:
6q14.1
Exon count:
22
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 6 NC_000006.12 (80004605..80042527)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (80714322..80752244)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene glyceraldehyde 3 phosphate dehydrogenase pseudogene 63 Neighboring gene ribosomal protein L35a pseudogene 18 Neighboring gene Rho GTPase activating protein 21 pseudogene Neighboring gene adenylate kinase 4 pseudogene 5

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Cell cycle, organism-specific biosystem (from KEGG)
    Cell cycle, organism-specific biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
  • Cell cycle, conserved biosystem (from KEGG)
    Cell cycle, conserved biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
  • RB in Cancer, organism-specific biosystem (from WikiPathways)
    RB in Cancer, organism-specific biosystem
    RB in Cancer
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ38280

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein serine/threonine/tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
chromosome separation IEA
Inferred from Electronic Annotation
more info
 
mitotic spindle assembly checkpoint TAS
Traceable Author Statement
more info
PubMed 
mitotic spindle organization TAS
Traceable Author Statement
more info
PubMed 
peptidyl-tyrosine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
peptidyl-tyrosine phosphorylation TAS
Traceable Author Statement
more info
PubMed 
positive regulation of cell proliferation TAS
Traceable Author Statement
more info
PubMed 
positive regulation of pathway-restricted SMAD protein phosphorylation TAS
Traceable Author Statement
more info
PubMed 
spindle organization TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
membrane IDA
Inferred from Direct Assay
more info
PubMed 
spindle TAS
Traceable Author Statement
more info
PubMed 
Preferred Names
dual specificity protein kinase TTK
Names
dual specificity protein kinase TTK
cancer/testis antigen 96
monopolar spindle 1 kinase
monopolar spindle 1-like 1
phosphotyrosine picked threonine kinase
phosphotyrosine picked threonine-protein kinase
NP_001160163.1
NP_003309.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001166691.1NP_001160163.1  dual specificity protein kinase TTK isoform 2

    See proteins identical to NP_001160163.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses alternate in-frame splice sites in the 5' UTR and in the central coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AK292460, AL133475, AU154042, DA853919
    Consensus CDS
    CCDS55040.1
    UniProtKB/Swiss-Prot
    P33981
    Related
    ENSP00000230510, OTTHUMP00000016778, ENST00000230510, OTTHUMT00000041317
    Conserved Domains (2) summary
    smart00220
    Location:524790
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14131
    Location:522790
    PKc_Mps1; Catalytic domain of the Dual-specificity Mitotic checkpoint protein kinase, Monopolar spindle 1 (also called TTK)
  2. NM_003318.4NP_003309.2  dual specificity protein kinase TTK isoform 1

    See proteins identical to NP_003309.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK315696, AU154042, DA853919
    Consensus CDS
    CCDS4993.1
    UniProtKB/Swiss-Prot
    P33981
    Related
    ENSP00000358813, OTTHUMP00000016777, ENST00000369798, OTTHUMT00000041316
    Conserved Domains (2) summary
    smart00220
    Location:525791
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14131
    Location:523791
    PKc_Mps1; Catalytic domain of the Dual-specificity Mitotic checkpoint protein kinase, Monopolar spindle 1 (also called TTK)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p2 Primary Assembly

    Range
    80004605..80042527
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011536100.1XP_011534402.1  

    See proteins identical to XP_011534402.1

    Related
    ENSP00000422936, OTTHUMP00000220743, ENST00000509894, OTTHUMT00000366101
    Conserved Domains (2) summary
    smart00220
    Location:524790
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14131
    Location:522790
    PKc_Mps1; Catalytic domain of the Dual-specificity Mitotic checkpoint protein kinase, Monopolar spindle 1 (also called TTK)
  2. XM_011536099.1XP_011534401.1  

    See proteins identical to XP_011534401.1

    Conserved Domains (2) summary
    smart00220
    Location:525791
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14131
    Location:523791
    PKc_Mps1; Catalytic domain of the Dual-specificity Mitotic checkpoint protein kinase, Monopolar spindle 1 (also called TTK)

Alternate CHM1_1.1

Genomic

  1. NC_018917.2 Alternate CHM1_1.1

    Range
    80811776..80849705
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)