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Rag1 recombination activating gene 1 [ Mus musculus (house mouse) ]

Gene ID: 19373, updated on 24-Apr-2015
Official Symbol
Rag1provided by MGI
Official Full Name
recombination activating gene 1provided by MGI
Primary source
MGI:MGI:97848
See related
Ensembl:ENSMUSG00000061311; Vega:OTTMUSG00000014584
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rag-1
Orthologs
See Rag1 in MapViewer
Location:
2 E2; 2 53.88 cM
Exon count:
3
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 2 NC_000068.7 (101638252..101649532, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (101478409..101489689, complement)

Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105244244 Neighboring gene RIKEN cDNA B230118H07 gene Neighboring gene recombination activating gene 2 Neighboring gene predicted gene, 34041 Neighboring gene TNF receptor-associated factor 6

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • FoxO signaling pathway, organism-specific biosystem (from KEGG)
    FoxO signaling pathway, organism-specific biosystemThe forkhead box O (FOXO) family of transcription factors regulates the expression of genes in cellular physiological events including apoptosis, cell-cycle control, glucose metabolism, oxidative str...
  • Primary immunodeficiency, organism-specific biosystem (from KEGG)
    Primary immunodeficiency, organism-specific biosystemPrimary immunodeficiencies (PIs) are a heterogeneous group of disorders, which affect cellular and humoral immunity or non-specific host defense mechanisms mediated by complement proteins, and cells ...
  • Primary immunodeficiency, conserved biosystem (from KEGG)
    Primary immunodeficiency, conserved biosystemPrimary immunodeficiencies (PIs) are a heterogeneous group of disorders, which affect cellular and humoral immunity or non-specific host defense mechanisms mediated by complement proteins, and cells ...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
T/G mismatch-specific endonuclease activity IEA
Inferred from Electronic Annotation
more info
 
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity IEA
Inferred from Electronic Annotation
more info
 
acid-amino acid ligase activity IEA
Inferred from Electronic Annotation
more info
 
catalytic activity IEA
Inferred from Electronic Annotation
more info
 
coenzyme F420-0 gamma-glutamyl ligase activity IEA
Inferred from Electronic Annotation
more info
 
coenzyme F420-2 alpha-glutamyl ligase activity IEA
Inferred from Electronic Annotation
more info
 
endonuclease activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
endonuclease activity ISO
Inferred from Sequence Orthology
more info
 
histone binding IDA
Inferred from Direct Assay
more info
PubMed 
histone binding ISO
Inferred from Sequence Orthology
more info
 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
hydrolase activity, acting on ester bonds IEA
Inferred from Electronic Annotation
more info
 
ligase activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
metal ion binding ISO
Inferred from Sequence Orthology
more info
 
nuclease activity IEA
Inferred from Electronic Annotation
more info
 
nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
phosphoric ester hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
protein-glutamic acid ligase activity IEA
Inferred from Electronic Annotation
more info
 
protein-glycine ligase activity IEA
Inferred from Electronic Annotation
more info
 
protein-glycine ligase activity, elongating IEA
Inferred from Electronic Annotation
more info
 
protein-glycine ligase activity, initiating IEA
Inferred from Electronic Annotation
more info
 
retroviral 3' processing activity IEA
Inferred from Electronic Annotation
more info
 
ribosomal S6-glutamic acid ligase activity IEA
Inferred from Electronic Annotation
more info
 
sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
sequence-specific DNA binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
tubulin-glutamic acid ligase activity IEA
Inferred from Electronic Annotation
more info
 
tubulin-glycine ligase activity IEA
Inferred from Electronic Annotation
more info
 
ubiquitin protein ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
 
ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
 
zinc ion binding IDA
Inferred from Direct Assay
more info
PubMed 
zinc ion binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
B cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
B cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
B cell differentiation ISO
Inferred from Sequence Orthology
more info
 
DNA recombination TAS
Traceable Author Statement
more info
PubMed 
T cell differentiation in thymus IMP
Inferred from Mutant Phenotype
more info
PubMed 
T cell differentiation in thymus ISO
Inferred from Sequence Orthology
more info
 
T cell homeostasis IGI
Inferred from Genetic Interaction
more info
PubMed 
V(D)J recombination IGI
Inferred from Genetic Interaction
more info
PubMed 
V(D)J recombination IMP
Inferred from Mutant Phenotype
more info
PubMed 
V(D)J recombination ISO
Inferred from Sequence Orthology
more info
 
adaptive immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
chromatin modification IEA
Inferred from Electronic Annotation
more info
 
death IMP
Inferred from Mutant Phenotype
more info
PubMed 
histone monoubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
histone monoubiquitination ISO
Inferred from Sequence Orthology
more info
 
metabolic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of T cell apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of thymocyte apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
nucleic acid phosphodiester bond hydrolysis IMP
Inferred from Mutant Phenotype
more info
PubMed 
nucleic acid phosphodiester bond hydrolysis ISO
Inferred from Sequence Orthology
more info
 
pre-B cell allelic exclusion IMP
Inferred from Mutant Phenotype
more info
PubMed 
pre-B cell allelic exclusion ISO
Inferred from Sequence Orthology
more info
 
protein autoubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
protein autoubiquitination ISO
Inferred from Sequence Orthology
more info
 
regulation of T cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
thymus development IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
V(D)J recombination-activating protein 1
Names
V(D)J recombination-activating protein 1
recombinase activating gene 1
recombination activating protein 1
recombination-activating gene 1
NP_033045.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009019.2NP_033045.2  V(D)J recombination-activating protein 1

    See identical proteins and their annotated locations for NP_033045.2

    Status: VALIDATED

    Source sequence(s)
    AK162974, AL929569
    Consensus CDS
    CCDS16463.1
    UniProtKB/Swiss-Prot
    P15919
    UniProtKB/TrEMBL
    Q3TR87
    Related
    ENSMUSP00000077584, OTTMUSP00000015477, ENSMUST00000078494, OTTMUST00000034580
    Conserved Domains (3) summary
    pfam10426
    Location:351380
    zf-RAG1; Recombination-activating protein 1 zinc-finger domain
    pfam12940
    Location:510950
    RAG1; Recombination-activation protein 1 (RAG1)
    cd00162
    Location:290332
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000068.7 Reference GRCm38.p3 C57BL/6J

    Range
    101638252..101649532
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006499012.1XP_006499075.1  

    See identical proteins and their annotated locations for XP_006499075.1

    UniProtKB/Swiss-Prot
    P15919
    Conserved Domains (3) summary
    pfam10426
    Location:351380
    zf-RAG1; Recombination-activating protein 1 zinc-finger domain
    pfam12940
    Location:510950
    RAG1; Recombination-activation protein 1 (RAG1)
    cd00162
    Location:290332
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably ...

Alternate Mm_Celera

Genomic

  1. AC_000024.1 Alternate Mm_Celera

    Range
    102863243..102874521
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)