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MPO myeloperoxidase [ Homo sapiens (human) ]

Gene ID: 4353, updated on 15-Sep-2014
Official Symbol
MPOprovided by HGNC
Official Full Name
myeloperoxidaseprovided by HGNC
Primary source
HGNC:HGNC:7218
See related
Ensembl:ENSG00000005381; HPRD:06102; MIM:606989; Vega:OTTHUMG00000178922
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Myeloperoxidase (MPO) is a heme protein synthesized during myeloid differentiation that constitutes the major component of neutrophil azurophilic granules. Produced as a single chain precursor, myeloperoxidase is subsequently cleaved into a light and heavy chain. The mature myeloperoxidase is a tetramer composed of 2 light chains and 2 heavy chains. This enzyme produces hypohalous acids central to the microbicidal activity of netrophils. [provided by RefSeq, Jul 2008]
Location:
17q23.1
Exon count:
12
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 17 NC_000017.11 (58269856..58280935, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (56347217..56358296, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene Meckel syndrome, type 1 Neighboring gene lactoperoxidase Neighboring gene benzodiazepine receptor (peripheral) associated protein 1 Neighboring gene BZRAP1 antisense RNA 1 Neighboring gene microRNA 142

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Associated conditions

Description Tests
Alzheimer's disease
MedGen: C0002395 OMIM: 104300 GeneReviews: Alzheimer Disease Overview
Compare labs
Myeloperoxidase deficiency
MedGen: C0398595 OMIM: 254600 GeneReviews: Not available
Compare labs

NHGRI GWAS Catalog

Description
Genome-wide and gene-centric analyses of circulating myeloperoxidase levels in the charge and care consortia.
NHGRI GWA Catalog

Replication interactions

Interaction Pubs
Knockdown of myeloperoxidase (MPO) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat upregulates myeloperoxidase in HEK 293T cells PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
chromatin binding TAS
Traceable Author Statement
more info
PubMed 
heme binding IEA
Inferred from Electronic Annotation
more info
 
heparin binding IDA
Inferred from Direct Assay
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
peroxidase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
aging IEA
Inferred from Electronic Annotation
more info
 
defense response TAS
Traceable Author Statement
more info
PubMed 
defense response to fungus IEA
Inferred from Electronic Annotation
more info
 
hydrogen peroxide catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
hypochlorous acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
low-density lipoprotein particle remodeling IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of apoptotic process TAS
Traceable Author Statement
more info
PubMed 
negative regulation of growth of symbiont in host IEA
Inferred from Electronic Annotation
more info
 
oxidation-reduction process IDA
Inferred from Direct Assay
more info
PubMed 
removal of superoxide radicals IEA
Inferred from Electronic Annotation
more info
 
respiratory burst involved in defense response IEA
Inferred from Electronic Annotation
more info
 
response to food IEA
Inferred from Electronic Annotation
more info
 
response to lipopolysaccharide IEA
Inferred from Electronic Annotation
more info
 
response to mechanical stimulus IEA
Inferred from Electronic Annotation
more info
 
response to oxidative stress TAS
Traceable Author Statement
more info
PubMed 
response to yeast IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
azurophil granule IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
extracellular vesicular exosome IDA
Inferred from Direct Assay
more info
PubMed 
lysosome TAS
Traceable Author Statement
more info
PubMed 
mitochondrion IEA
Inferred from Electronic Annotation
more info
 
nucleus IDA
Inferred from Direct Assay
more info
 
secretory granule IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
myeloperoxidase
Names
myeloperoxidase
NP_000241.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_009629.1 

    Range
    5001..16080
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_84

mRNA and Protein(s)

  1. NM_000250.1NP_000241.1  myeloperoxidase precursor

    See proteins identical to NP_000241.1

    Status: REVIEWED

    Source sequence(s)
    M19507
    Consensus CDS
    CCDS11604.1
    UniProtKB/Swiss-Prot
    P05164
    Related
    ENSP00000225275, OTTHUMP00000260337, ENST00000225275, OTTHUMT00000443971
    Conserved Domains (2) summary
    cd09824
    Location:316728
    myeloperoxidase_like; Myeloperoxidases, eosinophil peroxidases, and lactoperoxidases
    pfam03098
    Location:173715
    An_peroxidase; Animal haem peroxidase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000017.11 

    Range
    58269856..58280935
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000149.1 

    Range
    51708013..51718966
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018928.2 

    Range
    56412238..56423315
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)