Display Settings:

Format

Send to:

Choose Destination

Stk11 serine/threonine kinase 11 [ Mus musculus (house mouse) ]

Gene ID: 20869, updated on 26-Apr-2015
Official Symbol
Stk11provided by MGI
Official Full Name
serine/threonine kinase 11provided by MGI
Primary source
MGI:MGI:1341870
See related
Ensembl:ENSMUSG00000003068; Vega:OTTMUSG00000000002
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Lkb1; Par-4; R75140; AA408040
Summary
This gene encodes a member of the serine/threonine kinase family. The encoded protein, a known tumor suppressor, activates (via phosphorylation) adenine monophosphate-activated protein kinase (AMPK) and AMPK-related kinase proteins. This upstream regulation of the AMPK pathway is thought to regulate a number of different processes, including cell metabolism, cell polarity, apoptosis and DNA damage response. Mutations in a similar gene in human have been associated with Peutz-Jeghers syndrome. Alternative splicing results in multiple transcript variants, including the S isoform which plays a potential role in spermiogenesis. [provided by RefSeq, Sep 2014]
Orthologs
See Stk11 in MapViewer
Location:
10; 10 C1
Exon count:
13
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 10 NC_000076.6 (80115693..80130685)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (79579281..79593215)

Chromosome 10 - NC_000076.6Genomic Context describing neighboring genes Neighboring gene glutathione peroxidase 4 Neighboring gene strawberry notch homolog 2 (Drosophila) Neighboring gene downstream of Stk11 Neighboring gene ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit Neighboring gene midnolin

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding ISO
Inferred from Sequence Orthology
more info
 
LRR domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
kinase activity IEA
Inferred from Electronic Annotation
more info
 
magnesium ion binding ISO
Inferred from Sequence Orthology
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
p53 binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein complex binding ISO
Inferred from Sequence Orthology
more info
 
protein kinase activator activity IDA
Inferred from Direct Assay
more info
PubMed 
protein kinase activator activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein kinase activator activity ISO
Inferred from Sequence Orthology
more info
 
protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein serine/threonine kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
transferase activity, transferring phosphorus-containing groups IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
Golgi localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
T cell receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
T cell receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
TCR signalosome assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
activation of protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
activation of protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
anoikis ISO
Inferred from Sequence Orthology
more info
 
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
autophagy IEA
Inferred from Electronic Annotation
more info
 
axonogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
axonogenesis ISO
Inferred from Sequence Orthology
more info
 
canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell cycle IEA
Inferred from Electronic Annotation
more info
 
cell cycle arrest ISO
Inferred from Sequence Orthology
more info
 
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
cellular response to DNA damage stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to DNA damage stimulus ISO
Inferred from Sequence Orthology
more info
 
cellular response to UV-B IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to UV-B ISO
Inferred from Sequence Orthology
more info
 
dendrite extension IMP
Inferred from Mutant Phenotype
more info
PubMed 
establishment of cell polarity IMP
Inferred from Mutant Phenotype
more info
PubMed 
glucose homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
intrinsic apoptotic signaling pathway by p53 class mediator ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell growth IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of epithelial cell proliferation involved in prostate gland development IMP
Inferred from Mutant Phenotype
more info
PubMed 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of axonogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of gluconeogenesis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of peptidyl-tyrosine phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein localization to nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transforming growth factor beta receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive thymic T cell selection IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
protein heterooligomerization ISO
Inferred from Sequence Orthology
more info
 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
regulation of Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cell growth IDA
Inferred from Direct Assay
more info
PubMed 
regulation of dendrite morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of protein kinase B signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to ionizing radiation IDA
Inferred from Direct Assay
more info
PubMed 
response to lipid ISO
Inferred from Sequence Orthology
more info
 
spermatid development IMP
Inferred from Mutant Phenotype
more info
PubMed 
spermatogenesis IEA
Inferred from Electronic Annotation
more info
 
tissue homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
vasculature development IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
TCR signalosome IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IMP
Inferred from Mutant Phenotype
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion ISO
Inferred from Sequence Orthology
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
protein complex ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
serine/threonine-protein kinase STK11
Names
serine/threonine-protein kinase STK11
liver kinase B1 homolog
serine/threonine-protein kinase 11
serine/threonine-protein kinase LKB1
stk11
NP_001288782.1
NP_001288783.1
NP_035622.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001301853.1NP_001288782.1  serine/threonine-protein kinase STK11 isoform S

    See identical proteins and their annotated locations for NP_001288782.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (S, see PMID:18774945) has a distinct C-terminus and is shorter than isoform L.
    Source sequence(s)
    AC159999, BC052379, BE951985, CO424479, EU730638
    UniProtKB/Swiss-Prot
    Q9WTK7
    Conserved Domains (2) summary
    smart00220
    Location:49309
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14119
    Location:55309
    STKc_LKB1; Catalytic domain of the Serine/Threonine kinase, Liver Kinase B1
  2. NM_001301854.1NP_001288783.1  serine/threonine-protein kinase STK11 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 5' terminal exon, and initiates translation at a downstream in-frame start codon, compared to variant 1. The resulting protein (isoform 3) has a shorter N-terminus, compared to isoform L.
    Source sequence(s)
    AC159999, AK004499, AK147802, BC052379, CJ229363
    UniProtKB/TrEMBL
    Q3V4A1
    UniProtKB/Swiss-Prot
    Q9WTK7
    Conserved Domains (2) summary
    smart00220
    Location:1185
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:1185
    PKc_like; Catalytic domain of the Protein Kinase superfamily
  3. NM_011492.4NP_035622.1  serine/threonine-protein kinase STK11 isoform L

    See identical proteins and their annotated locations for NP_035622.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (L, see PMID:18774945).
    Source sequence(s)
    AC159999, AK004499, BC052379, BE951985, CJ229363, CO424479
    Consensus CDS
    CCDS35974.1
    UniProtKB/TrEMBL
    Q3V4A1
    UniProtKB/Swiss-Prot
    Q9WTK7
    Related
    ENSMUSP00000003152, OTTMUSP00000020599, ENSMUST00000003152, OTTMUST00000045747
    Conserved Domains (2) summary
    smart00220
    Location:49309
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14119
    Location:55309
    STKc_LKB1; Catalytic domain of the Serine/Threonine kinase, Liver Kinase B1

RNA

  1. NR_126043.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) contains an alternate exon in the 3' region compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in the variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC159999, AK004499, BC052379, BE951985, BF468348, CD565465, CJ229363, CO424479, EU730638

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000076.6 Reference GRCm38.p3 C57BL/6J

    Range
    80115693..80130685
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006513443.2XP_006513506.1  

    Conserved Domains (1) summary
    cl21453
    Location:55155
    PKc_like; Catalytic domain of the Protein Kinase superfamily
  2. XM_006513441.2XP_006513504.1  

    Conserved Domains (2) summary
    smart00220
    Location:49245
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:55245
    PKc_like; Catalytic domain of the Protein Kinase superfamily
  3. XM_006513442.2XP_006513505.1  

    Conserved Domains (1) summary
    cl21453
    Location:23132
    PKc_like; Catalytic domain of the Protein Kinase superfamily
  4. XM_006513439.2XP_006513502.1  

    Conserved Domains (2) summary
    smart00220
    Location:79291
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14119
    Location:79291
    STKc_LKB1; Catalytic domain of the Serine/Threonine kinase, Liver Kinase B1

Alternate Mm_Celera

Genomic

  1. AC_000032.1 Alternate Mm_Celera

    Range
    81130635..81145517
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)