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Angpt1 angiopoietin 1 [ Mus musculus (house mouse) ]

Gene ID: 11600, updated on 19-Dec-2014
Official Symbol
Angpt1provided by MGI
Official Full Name
angiopoietin 1provided by MGI
Primary source
MGI:MGI:108448
See related
Ensembl:ENSMUSG00000022309
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ang1; Ang-1; 1110046O21Rik
Summary
This gene encodes a secreted glycoprotein that belongs to the angiopoietin family of vascular growth factors. The encoded protein is a ligand in the vascular tyrosine kinase signaling pathway and regulates the formation and stabilization of blood vessels. This protein also functions in striated muscles by promoting proliferation, migration and differentiation of skeletal myoblasts and plays an essential role in the vascular response to tissue injury. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2013]
See Angpt1 in Epigenomics, MapViewer
Location:
15 B3.1; 15 16.69 cM
Exon count:
10
Annotation release Status Assembly Chr Location
104 current GRCm38.p2 (GCF_000001635.22) 15 NC_000081.6 (42424667..42676977, complement)

Chromosome 15 - NC_000081.6Genomic Context describing neighboring genes Neighboring gene crumbs homolog 1 pseudogene Neighboring gene ribosomal protein L5 pseudogene Neighboring gene predicted gene, 33664 Neighboring gene R-spondin 2 homolog (Xenopus laevis)

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Cell surface interactions at the vascular wall, organism-specific biosystem (from REACTOME)
    Cell surface interactions at the vascular wall, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • HIF-1 signaling pathway, organism-specific biosystem (from KEGG)
    HIF-1 signaling pathway, organism-specific biosystemHypoxia-inducible factor 1 (HIF-1) is a transcription factor that functions as a master regulator of oxygen homeostasis. It consists of two subunits: an inducibly-expressed HIF-1alpha subunit and a c...
  • Hemostasis, organism-specific biosystem (from REACTOME)
    Hemostasis, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • PI3K-Akt signaling pathway, organism-specific biosystem (from KEGG)
    PI3K-Akt signaling pathway, organism-specific biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
  • PI3K-Akt signaling pathway, conserved biosystem (from KEGG)
    PI3K-Akt signaling pathway, conserved biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
  • PodNet: protein-protein interactions in the podocyte, organism-specific biosystem (from WikiPathways)
    PodNet: protein-protein interactions in the podocyte, organism-specific biosystemPodNet is a manually curated network of protein-protein interactions occurring in the podocyte.
  • Rap1 signaling pathway, organism-specific biosystem (from KEGG)
    Rap1 signaling pathway, organism-specific biosystemRap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an ac...
  • Rap1 signaling pathway, conserved biosystem (from KEGG)
    Rap1 signaling pathway, conserved biosystemRap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an ac...
  • Ras signaling pathway, organism-specific biosystem (from KEGG)
    Ras signaling pathway, organism-specific biosystemThe Ras proteins are GTPases that function as molecular switches for signaling pathways regulating cell proliferation, survival, growth, migration, differentiation or cytoskeletal dynamism. Ras prote...
  • Rheumatoid arthritis, organism-specific biosystem (from KEGG)
    Rheumatoid arthritis, organism-specific biosystemRheumatoid arthritis (RA) is a chronic autoimmune joint disease where persistent inflammation affects bone remodeling leading to progressive bone destruction. In RA, abnormal activation of the immune...
  • Rheumatoid arthritis, conserved biosystem (from KEGG)
    Rheumatoid arthritis, conserved biosystemRheumatoid arthritis (RA) is a chronic autoimmune joint disease where persistent inflammation affects bone remodeling leading to progressive bone destruction. In RA, abnormal activation of the immune...
  • Tie2 Signaling, organism-specific biosystem (from REACTOME)
    Tie2 Signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • XPodNet - protein-protein interactions in the podocyte expanded by STRING, organism-specific biosystem (from WikiPathways)
    XPodNet - protein-protein interactions in the podocyte expanded by STRING, organism-specific biosystemXPodNet is a larger version of PodNet. Interactions from STRING database have been added to PodNet to build XPodNet. Hence, not all interactions found in XPodNet do necessarily have to be curated.

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
receptor tyrosine kinase binding ISO
Inferred from Sequence Orthology
more info
 
vascular endothelial growth factor receptor binding TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
Tie signaling pathway ISO
Inferred from Sequence Orthology
more info
 
Tie signaling pathway TAS
Traceable Author Statement
more info
PubMed 
activation of transmembrane receptor protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
 
angiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
cardiac muscle tissue morphogenesis TAS
Traceable Author Statement
more info
PubMed 
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
cell-substrate adhesion IDA
Inferred from Direct Assay
more info
PubMed 
endocardium morphogenesis TAS
Traceable Author Statement
more info
PubMed 
endoderm development TAS
Traceable Author Statement
more info
PubMed 
glomerulus vasculature development IDA
Inferred from Direct Assay
more info
PubMed 
glomerulus vasculature development ISO
Inferred from Sequence Orthology
more info
 
hemopoiesis IDA
Inferred from Direct Assay
more info
PubMed 
heparin biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
in utero embryonic development IGI
Inferred from Genetic Interaction
more info
PubMed 
in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
multicellular organismal development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell adhesion ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cytokine secretion involved in immune response IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of endothelial cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of neuron apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of neuron apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of protein import into nucleus IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of vascular permeability IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of vascular permeability ISO
Inferred from Sequence Orthology
more info
 
ovarian follicle development ISO
Inferred from Sequence Orthology
more info
 
patterning of blood vessels TAS
Traceable Author Statement
more info
PubMed 
positive chemotaxis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
positive regulation of blood vessel endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell adhesion IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of endothelial cell migration TAS
Traceable Author Statement
more info
PubMed 
positive regulation of peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of phosphatidylinositol 3-kinase signaling IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein kinase B signaling ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein ubiquitination ISO
Inferred from Sequence Orthology
more info
 
positive regulation of receptor internalization ISO
Inferred from Sequence Orthology
more info
 
positive regulation of vascular endothelial growth factor receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
protein homooligomerization ISO
Inferred from Sequence Orthology
more info
 
protein localization to cell surface ISO
Inferred from Sequence Orthology
more info
 
regulation of I-kappaB kinase/NF-kappaB signaling IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of macrophage migration inhibitory factor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
regulation of protein binding IDA
Inferred from Direct Assay
more info
PubMed 
regulation of satellite cell proliferation ISO
Inferred from Sequence Orthology
more info
 
regulation of tumor necrosis factor production IDA
Inferred from Direct Assay
more info
PubMed 
sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
 
transmembrane receptor protein tyrosine kinase signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
vasculogenesis TAS
Traceable Author Statement
more info
PubMed 
vasculogenesis involved in coronary vascular morphogenesis TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
extracellular region IEA
Inferred from Electronic Annotation
more info
 
extracellular space ISO
Inferred from Sequence Orthology
more info
 
extracellular vesicular exosome ISO
Inferred from Sequence Orthology
more info
 
membrane raft ISO
Inferred from Sequence Orthology
more info
 
microvillus ISO
Inferred from Sequence Orthology
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
angiopoietin-1
Names
angiopoietin-1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286062.1NP_001272991.1  angiopoietin-1 isoform 2 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region compared to variant 1. This encoded protein (isoform 2) is shorter than isoform 1.
    Source sequence(s)
    AC100734, AC101713, AC161347
    Conserved Domains (3) summary
    pfam07956
    Location:77200
    DUF1690; Protein of Unknown function (DUF1690)
    cd00087
    Location:280495
    FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
    cl19219
    Location:172246
    DUF342; Protein of unknown function (DUF342)
  2. NM_009640.4NP_033770.2  angiopoietin-1 isoform 1 precursor

    See proteins identical to NP_033770.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC100734, AC101713, BC067410
    Consensus CDS
    CCDS27450.1
    UniProtKB/Swiss-Prot
    O08538
    Related
    ENSMUSP00000022921, ENSMUST00000022921
    Conserved Domains (2) summary
    pfam07956
    Location:77210
    DUF1690; Protein of Unknown function (DUF1690)
    cd00087
    Location:281496
    FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p2 C57BL/6J

Genomic

  1. NC_000081.6 

    Range
    42424667..42676977
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006520323.1XP_006520386.1  

    Conserved Domains (2) summary
    cd00087
    Location:183398
    FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
    cl19219
    Location:74148
    DUF342; Protein of unknown function (DUF342)

Alternate Mm_Celera

Genomic

  1. AC_000037.1 

    Range
    42923745..43172815
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)