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    JAK2 Janus kinase 2 [ Homo sapiens (human) ]

    Gene ID: 3717, updated on 22-Aug-2016
    Official Symbol
    JAK2provided by HGNC
    Official Full Name
    Janus kinase 2provided by HGNC
    Primary source
    HGNC:HGNC:6192
    See related
    Ensembl:ENSG00000096968 HPRD:00993; MIM:147796; Vega:OTTHUMG00000019490
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    JTK10; THCYT3
    Summary
    This gene product is a protein tyrosine kinase involved in a specific subset of cytokine receptor signaling pathways. It has been found to be constituitively associated with the prolactin receptor and is required for responses to gamma interferon. Mice that do not express an active protein for this gene exhibit embryonic lethality associated with the absence of definitive erythropoiesis. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    9p24
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 9 NC_000009.12 (4985086..5128183)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (4985245..5129948)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene RNA terminal phosphate cyclase like 1 Neighboring gene microRNA 101-2 Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene 41 Neighboring gene insulin like 6 Neighboring gene casein kinase 1 gamma 2 pseudogene 1 Neighboring gene uncharacterized LOC107987044 Neighboring gene prenyl (decaprenyl) diphosphate synthase, subunit 1 pseudogene 1 Neighboring gene mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 5 pseudogene 36 Neighboring gene mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 2 pseudogene 36 Neighboring gene mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1 pseudogene 11 Neighboring gene mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 6 pseudogene 5 Neighboring gene mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 3 pseudogene 14 Neighboring gene mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 4L pseudogene 6 Neighboring gene mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 4 pseudogene 14 Neighboring gene mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 5 pseudogene 14 Neighboring gene transcription factor 3 pseudogene 1 Neighboring gene immunoglobulin heavy constant epsilon P2 (pseudogene) Neighboring gene insulin like 4 Neighboring gene relaxin 2

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Associated conditions

    Description Tests
    Budd-Chiari syndrome
    MedGen: C0856761 OMIM: 600880 GeneReviews: Not available
    Compare labs
    Familial erythrocytosis, 1
    MedGen: C1851490 OMIM: 133100 GeneReviews: Not available
    Compare labs
    Myelofibrosis
    MedGen: C0001815 OMIM: 254450 GeneReviews: Not available
    Compare labs
    Polycythemia vera
    MedGen: C0032463 OMIM: 263300 GeneReviews: Not available
    Compare labs
    Thrombocythemia 3
    MedGen: C3281125 OMIM: 614521 GeneReviews: Not available
    Compare labs

    NHGRI GWAS Catalog

    Description
    A genome-wide association study identifies 2 susceptibility Loci for Crohn's disease in a Japanese population.
    NHGRI GWA Catalog
    A genome-wide association study identifies three new susceptibility loci for ulcerative colitis in the Japanese population.
    NHGRI GWA Catalog
    A germline JAK2 SNP is associated with predisposition to the development of JAK2(V617F)-positive myeloproliferative neoplasms.
    NHGRI GWA Catalog
    Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease.
    NHGRI GWA Catalog
    Genome-wide association identifies multiple ulcerative colitis susceptibility loci.
    NHGRI GWA Catalog
    Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
    NHGRI GWA Catalog
    Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
    NHGRI GWA Catalog
    Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.
    NHGRI GWA Catalog

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat-mediated upregulation of CCL5 involves JAK2/3, AKT2/3, p38delta, NF-kappaB (p65/p50), C/EBP alpha/gamma, and AP-1 proteins PubMed

    Go to the HIV-1, Human Interaction Database

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    • MAPK family signaling cascades, organism-specific biosystem (from REACTOME)
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    • MAPK1 (ERK2) activation, organism-specific biosystem (from REACTOME)
      MAPK1 (ERK2) activation, organism-specific biosystemMitogen-activated protein kinase kinase MAP2K2 (also known as MEK2) is a dual threonine and tyrosine recognition kinase that phosphorylates and activates MAPK1 (ERK2) (Ohren et al. 2004; Roskoski 201...
    • MAPK1/MAPK3 signaling, organism-specific biosystem (from REACTOME)
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    • MAPK3 (ERK1) activation, organism-specific biosystem (from REACTOME)
      MAPK3 (ERK1) activation, organism-specific biosystemMitogen-activated protein kinase kinase MAP2K1 (also known as MEK1) is a dual threonine and tyrosine recognition kinase that phosphorylates and activates MAPK3 (ERK1) (Ohren et al. 2004; Roskoski 201...
    • Measles, organism-specific biosystem (from KEGG)
      Measles, organism-specific biosystemMeasles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacteri...
    • Measles, conserved biosystem (from KEGG)
      Measles, conserved biosystemMeasles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacteri...
    • NCAM signaling for neurite out-growth, organism-specific biosystem (from REACTOME)
      NCAM signaling for neurite out-growth, organism-specific biosystemThe neural cell adhesion molecule, NCAM, is a member of the immunoglobulin (Ig) superfamily and is involved in a variety of cellular processes of importance for the formation and maintenance of the n...
    • NGF signalling via TRKA from the plasma membrane, organism-specific biosystem (from REACTOME)
      NGF signalling via TRKA from the plasma membrane, organism-specific biosystemTrk receptors signal from the plasma membrane and from intracellular membranes, particularly from early endosomes. Signalling from the plasma membrane is fast but transient; signalling from endosomes...
    • Notch-mediated HES/HEY network, organism-specific biosystem (from Pathway Interaction Database)
      Notch-mediated HES/HEY network, organism-specific biosystem
      Notch-mediated HES/HEY network
    • Nuclear signaling by ERBB4, organism-specific biosystem (from REACTOME)
      Nuclear signaling by ERBB4, organism-specific biosystemBesides signaling as a transmembrane receptor, ligand activated homodimers of ERBB4 JM-A isoforms (ERBB4 JM-A CYT1 and ERBB4 JM-A CYT2) undergo proteolytic cleavage by ADAM17 (TACE) in the juxtamembr...
    • Oncostatin M Signaling Pathway, organism-specific biosystem (from WikiPathways)
      Oncostatin M Signaling Pathway, organism-specific biosystemOncostatin M (OSM) is a member of the multifunctional cytokine interleukin 6 (IL6) - type cytokine family. It is mainly produced in cell types such as activated T lymphocytes, macrophages, monocytes,...
    • PI3K-Akt signaling pathway, organism-specific biosystem (from KEGG)
      PI3K-Akt signaling pathway, organism-specific biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
    • PI3K-Akt signaling pathway, conserved biosystem (from KEGG)
      PI3K-Akt signaling pathway, conserved biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
    • Paxillin-independent events mediated by a4b1 and a4b7, organism-specific biosystem (from Pathway Interaction Database)
      Paxillin-independent events mediated by a4b1 and a4b7, organism-specific biosystem
      Paxillin-independent events mediated by a4b1 and a4b7
    • Platelet activation, signaling and aggregation, organism-specific biosystem (from REACTOME)
      Platelet activation, signaling and aggregation, organism-specific biosystemPlatelet activation begins with the initial binding of adhesive ligands and of the excitatory platelet agonists (released or generated at the sites of vascular trauma) to cognate receptors on the pla...
    • Prolactin Signaling Pathway, organism-specific biosystem (from WikiPathways)
      Prolactin Signaling Pathway, organism-specific biosystemProlactin (PRL), a pleiotropic polypeptide hormone, mostly secreted by the lactotrophic cells of anterior pituitary gland and to a lesser extent expressed in numerous extra pituitary tissues such as ...
    • Prolactin receptor signaling, organism-specific biosystem (from REACTOME)
      Prolactin receptor signaling, organism-specific biosystemProlactin (PRL) is a hormone secreted mainly by the anterior pituitary gland. It was originally identified by its ability to stimulate the development of the mammary gland and lactation, but is now k...
    • Prolactin signaling pathway, organism-specific biosystem (from KEGG)
      Prolactin signaling pathway, organism-specific biosystemProlactin (PRL) is a polypeptide hormone known to be involved in a wide range of biological functions including osmoregulation, lactation, reproduction, growth and development, endocrinology and meta...
    • Prolactin signaling pathway, conserved biosystem (from KEGG)
      Prolactin signaling pathway, conserved biosystemProlactin (PRL) is a polypeptide hormone known to be involved in a wide range of biological functions including osmoregulation, lactation, reproduction, growth and development, endocrinology and meta...
    • Prolonged ERK activation events, organism-specific biosystem (from REACTOME)
      Prolonged ERK activation events, organism-specific biosystemAfter NGF binding, activated Trk receptors provide multiple docking sites for adaptor proteins and enzymes. Two docking proteins, the Ankyrin-Rich Membrane Spanning protein (ARMS/Kidins220) and Fibro...
    • RAF activation, organism-specific biosystem (from REACTOME)
      RAF activation, organism-specific biosystemMammals have three RAF isoforms, A, B and C, that are activated downstream of RAS and stimulate the MAPK pathway. Although CRAF (also known as RAF-1) was the first identified and remains perhaps the ...
    • RAF-independent MAPK1/3 activation, organism-specific biosystem (from REACTOME)
      RAF-independent MAPK1/3 activation, organism-specific biosystemDepending upon the stimulus and cell type mitogen-activated protein kinases (MAPK) signaling pathway can transmit signals to regulate many different biological processes by virtue of their ability to...
    • RAF/MAP kinase cascade, organism-specific biosystem (from REACTOME)
      RAF/MAP kinase cascade, organism-specific biosystemThe RAS-RAF-MEK-ERK pathway regulates processes such as proliferation, differentiation, survival, senescence and cell motility in response to growth factors, hormones and cytokines, among others. Bin...
    • RMTs methylate histone arginines, organism-specific biosystem (from REACTOME)
      RMTs methylate histone arginines, organism-specific biosystemArginine methylation is a common post-translational modification; around 2% of arginine residues are methylated in rat liver nuclei (Boffa et al. 1977). Arginine can be methylated in 3 different ways...
    • Regulation of IFNG signaling, organism-specific biosystem (from REACTOME)
      Regulation of IFNG signaling, organism-specific biosystemAt least three different classes of negative regulators exist to control the extent of INFG stimulation and signaling. These include the feedback inhibitors belonging to protein family suppressors of...
    • S1P3 pathway, organism-specific biosystem (from Pathway Interaction Database)
      S1P3 pathway, organism-specific biosystem
      S1P3 pathway
    • SHC1 events in EGFR signaling, organism-specific biosystem (from REACTOME)
      SHC1 events in EGFR signaling, organism-specific biosystemGRB2 can bind EGFR directly or through another SH2-containing protein, SHC1. This association leads to RAS activation.
    • SHC1 events in ERBB4 signaling, organism-specific biosystem (from REACTOME)
      SHC1 events in ERBB4 signaling, organism-specific biosystemAll splicing isoforms of ERBB4 possess two tyrosine residues in the C-tail that serve as docking sites for SHC1 (Kaushansky et al. 2008, Pinkas-Kramarski et al. 1996, Cohen et al. 1996). Once bound t...
    • SOS-mediated signalling, organism-specific biosystem (from REACTOME)
      SOS-mediated signalling, organism-specific biosystemSOS is recruited to the plasma membrane and mediates activation of Ras.
    • Serotonin Receptor 2 and STAT3 Signaling, organism-specific biosystem (from WikiPathways)
      Serotonin Receptor 2 and STAT3 Signaling, organism-specific biosystemThis pathway is courtesy of Ariadne Genomics Pathway Studio.
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by EGFR, organism-specific biosystem (from REACTOME)
      Signaling by EGFR, organism-specific biosystemThe epidermal growth factor receptor (EGFR) is one member of the ERBB family of transmembrane glycoprotein tyrosine receptor kinases (RTK). Binding of EGFR to its ligands induces conformational chang...
    • Signaling by ERBB4, organism-specific biosystem (from REACTOME)
      Signaling by ERBB4, organism-specific biosystemERBB4, also known as HER4, belongs to the ERBB family of receptors, which also includes ERBB1 (EGFR i.e. HER1), ERBB2 (HER2 i.e. NEU) and ERBB3 (HER3). Similar to EGFR, ERBB4 has an extracellular lig...
    • Signaling by FGFR, organism-specific biosystem (from REACTOME)
      Signaling by FGFR, organism-specific biosystemThe 22 members of the fibroblast growth factor (FGF) family of growth factors mediate their cellular responses by binding to and activating the different isoforms encoded by the four receptor tyrosin...
    • Signaling by FGFR1, organism-specific biosystem (from REACTOME)
      Signaling by FGFR1, organism-specific biosystemThe 22 members of the fibroblast growth factor (FGF) family of growth factors mediate their cellular responses by binding to and activating the different isoforms encoded by the four receptor tyrosin...
    • Signaling by FGFR2, organism-specific biosystem (from REACTOME)
      Signaling by FGFR2, organism-specific biosystemThe 22 members of the fibroblast growth factor (FGF) family of growth factors mediate their cellular responses by binding to and activating the different isoforms encoded by the four receptor tyrosin...
    • Signaling by FGFR3, organism-specific biosystem (from REACTOME)
      Signaling by FGFR3, organism-specific biosystemThe 22 members of the fibroblast growth factor (FGF) family of growth factors mediate their cellular responses by binding to and activating the different isoforms encoded by the four receptor tyrosin...
    • Signaling by FGFR4, organism-specific biosystem (from REACTOME)
      Signaling by FGFR4, organism-specific biosystemThe 22 members of the fibroblast growth factor (FGF) family of growth factors mediate their cellular responses by binding to and activating the different isoforms encoded by the four receptor tyrosin...
    • Signaling by GPCR, organism-specific biosystem (from REACTOME)
      Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...
    • Signaling by Insulin receptor, organism-specific biosystem (from REACTOME)
      Signaling by Insulin receptor, organism-specific biosystemInsulin binding to its receptor results in receptor autophosphorylation on tyrosine residues and the tyrosine phosphorylation of insulin receptor substrates (e.g. IRS and Shc) by the insulin receptor...
    • Signaling by Interleukins, organism-specific biosystem (from REACTOME)
      Signaling by Interleukins, organism-specific biosystemInterleukins are low molecular weight proteins that bind to cell surface receptors and act in an autocrine and/or paracrine fashion. They were first identified as factors produced by leukocytes but a...
    • Signaling by Leptin, organism-specific biosystem (from REACTOME)
      Signaling by Leptin, organism-specific biosystemLeptin (LEP, OB, OBS), a circulating adipokine, and its receptor LEPR (DB, OBR) control food intake and energy balance and are implicated in obesity-related diseases (recently reviewed in Amitani et ...
    • Signaling by PDGF, organism-specific biosystem (from REACTOME)
      Signaling by PDGF, organism-specific biosystemPlatelet-derived Growth Factor (PDGF) is a potent stimulator of growth and motility of connective tissue cells such as fibroblasts and smooth muscle cells as well as other cells such as capillary end...
    • Signaling by SCF-KIT, organism-specific biosystem (from REACTOME)
      Signaling by SCF-KIT, organism-specific biosystemStem cell factor (SCF) is a growth factor with membrane bound and soluble forms. It is expressed by fibroblasts and endothelial cells throughout the body, promoting proliferation, migration, survival...
    • Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R), organism-specific biosystem (from REACTOME)
      Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R), organism-specific biosystemBinding of IGF1 (IGF-I) or IGF2 (IGF-II) to the extracellular alpha peptides of the type 1 insulin-like growth factor receptor (IGF1R) triggers the activation of two major signaling pathways: the SOS...
    • Signaling by VEGF, organism-specific biosystem (from REACTOME)
      Signaling by VEGF, organism-specific biosystemIn normal development vascular endothelial growth factors (VEGFs) are crucial regulators of vascular development during embryogenesis (vasculogenesis) and blood-vessel formation in the adult (angioge...
    • Signaling events mediated by PTP1B, organism-specific biosystem (from Pathway Interaction Database)
      Signaling events mediated by PTP1B, organism-specific biosystem
      Signaling events mediated by PTP1B
    • Signaling events mediated by Stem cell factor receptor (c-Kit), organism-specific biosystem (from Pathway Interaction Database)
      Signaling events mediated by Stem cell factor receptor (c-Kit), organism-specific biosystem
      Signaling events mediated by Stem cell factor receptor (c-Kit)
    • Signaling pathways regulating pluripotency of stem cells, organism-specific biosystem (from KEGG)
      Signaling pathways regulating pluripotency of stem cells, organism-specific biosystemPluripotent stem cells (PSCs) are basic cells with an indefinite self-renewal capacity and the potential to generate all the cell types of the three germinal layers. The types of PSCs known to date i...
    • Signaling pathways regulating pluripotency of stem cells, conserved biosystem (from KEGG)
      Signaling pathways regulating pluripotency of stem cells, conserved biosystemPluripotent stem cells (PSCs) are basic cells with an indefinite self-renewal capacity and the potential to generate all the cell types of the three germinal layers. The types of PSCs known to date i...
    • Signalling by NGF, organism-specific biosystem (from REACTOME)
      Signalling by NGF, organism-specific biosystemNeurotrophins (NGF, BDNF, NT-3, NT-4/5) play pivotal roles in survival, differentiation, and plasticity of neurons in the peripheral and central nervous system. They are produced, and secreted in mi...
    • Signalling to ERKs, organism-specific biosystem (from REACTOME)
      Signalling to ERKs, organism-specific biosystemNeurotrophins utilize multiple pathways to activate ERKs (ERK1 and ERK2), a subgroup of the large MAP kinase (MAPK) family, from the plasma membrane. The major signalling pathways to ERKs are via RAS...
    • Signalling to RAS, organism-specific biosystem (from REACTOME)
      Signalling to RAS, organism-specific biosystemSignalling through Shc adaptor proteins appears to be identical for both NGF and EGF. It leads to a fast, but transient, MAPK/ERK activation, which is insufficient to explain the prolonged activation...
    • Signalling to p38 via RIT and RIN, organism-specific biosystem (from REACTOME)
      Signalling to p38 via RIT and RIN, organism-specific biosystemRIT and RIN are two small guanine nucleotide binding proteins that share more than 50% sequence identity with RAS, including highly conserved core effector domains. Unlike RAS, the C termini of RIT a...
    • TSH signaling pathway, organism-specific biosystem (from WikiPathways)
      TSH signaling pathway, organism-specific biosystemHuman thyroid stimulating hormone (TSH) is a glycoprotein secreted by the anterior part of the pituitary gland (1). TSH plays an important physiological role in the regulation of the hypothalamic-pit...
    • TSLP Signaling Pathway, organism-specific biosystem (from WikiPathways)
      TSLP Signaling Pathway, organism-specific biosystemThymic stromal lymphopoietin (TSLP) is a type I cytokine member of interleukin-2 cytokine family. TSLP signals through interleukin-7 receptor a chain (IL-7Ra) and the TSLP receptor subunit (TSLPR), h...
    • Toxoplasmosis, organism-specific biosystem (from KEGG)
      Toxoplasmosis, organism-specific biosystemToxoplasma gondii is an obligate intracellular parasite that is prevalent worldwide. The tachyzoite form acquired by oral ingestion downmodulates proinflammatory signaling pathways via various mechan...
    • Toxoplasmosis, conserved biosystem (from KEGG)
      Toxoplasmosis, conserved biosystemToxoplasma gondii is an obligate intracellular parasite that is prevalent worldwide. The tachyzoite form acquired by oral ingestion downmodulates proinflammatory signaling pathways via various mechan...
    • Tuberculosis, organism-specific biosystem (from KEGG)
      Tuberculosis, organism-specific biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
    • Tuberculosis, conserved biosystem (from KEGG)
      Tuberculosis, conserved biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
    • Type II interferon signaling (IFNG), organism-specific biosystem (from WikiPathways)
      Type II interferon signaling (IFNG), organism-specific biosystemAdapted from Raza et al. (2008). This pathway is initiated by IFNG binding to its receptor and a subsequent phosphorylation cascade involving a number of the JAK and STAT family of proteins. Several ...
    • VEGFA-VEGFR2 Pathway, organism-specific biosystem (from REACTOME)
      VEGFA-VEGFR2 Pathway, organism-specific biosystemAngiogenesis is the formation of new blood vessels from preexisting vasculature. One of the most important proangiogenic factors is vascular endothelial growth factor (VEGF). VEGF exerts its biologic...
    • VEGFR2 mediated cell proliferation, organism-specific biosystem (from REACTOME)
      VEGFR2 mediated cell proliferation, organism-specific biosystemVEGFR2 stimulates ERK not via GRB2-SOS-RAS, but via pY1175-dependent phosphorylation of PLC gamma and subsequent activation of PKCs. PKC plays an important mediatory role in the proliferative Ras/Raf...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    Ras guanyl-nucleotide exchange factor activity TAS
    Traceable Author Statement
    more info
     
    SH2 domain binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    acetylcholine receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    growth hormone receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    growth hormone receptor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    heme binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    histone binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    histone kinase activity (H3-Y41 specific) IDA
    Inferred from Direct Assay
    more info
    PubMed 
    insulin receptor substrate binding IEA
    Inferred from Electronic Annotation
    more info
     
    interleukin-12 receptor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    non-membrane spanning protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    non-membrane spanning protein tyrosine kinase activity TAS
    Traceable Author Statement
    more info
     
    peptide hormone receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    phosphatidylinositol 3-kinase binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein C-terminus binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    protein kinase binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein tyrosine kinase activity EXP
    Inferred from Experiment
    more info
    PubMed 
    protein tyrosine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein tyrosine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein tyrosine kinase activity TAS
    Traceable Author Statement
    more info
     
    receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    type 1 angiotensin receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    G-protein coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    JAK-STAT cascade TAS
    Traceable Author Statement
    more info
    PubMed 
    JAK-STAT cascade involved in growth hormone signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    JAK-STAT cascade involved in growth hormone signaling pathway TAS
    Traceable Author Statement
    more info
     
    MAPK cascade TAS
    Traceable Author Statement
    more info
     
    STAT protein import into nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    actin filament polymerization NAS
    Non-traceable Author Statement
    more info
    PubMed 
    activation of JAK2 kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    activation of MAPKK activity IEA
    Inferred from Electronic Annotation
    more info
     
    activation of cysteine-type endopeptidase activity involved in apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    adaptive immune response IEA
    Inferred from Electronic Annotation
    more info
     
    apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    axon regeneration IEA
    Inferred from Electronic Annotation
    more info
     
    blood coagulation TAS
    Traceable Author Statement
    more info
     
    cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cytokine-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytokine-mediated signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enzyme linked receptor protein signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    erythrocyte differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    erythrocyte differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    extrinsic apoptotic signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    growth hormone receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    histone H3-Y41 phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    interferon-gamma-mediated signaling pathway TAS
    Traceable Author Statement
    more info
     
    interleukin-12-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    intracellular signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    intrinsic apoptotic signaling pathway in response to oxidative stress IEA
    Inferred from Electronic Annotation
    more info
     
    mammary gland epithelium development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    mesoderm development TAS
    Traceable Author Statement
    more info
    PubMed 
    mineralocorticoid receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    movement of cell or subcellular component TAS
    Traceable Author Statement
    more info
    PubMed 
    negative regulation of DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of cardiac muscle cell apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of cell-cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of heart contraction IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of neuron apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    peptidyl-tyrosine autophosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    peptidyl-tyrosine phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    platelet-derived growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cell activation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cell-substrate adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cytosolic calcium ion concentration IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of growth hormone receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of insulin secretion IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of interleukin-1 beta production IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of nitric oxide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of nitric-oxide synthase biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of peptidyl-tyrosine phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of phosphatidylinositol 3-kinase signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of phosphoprotein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of protein import into nucleus, translocation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of sequence-specific DNA binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of tumor necrosis factor production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of tyrosine phosphorylation of Stat3 protein ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of tyrosine phosphorylation of Stat5 protein ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein autophosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein phosphorylation TAS
    Traceable Author Statement
    more info
    PubMed 
    regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    regulation of cell proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    regulation of inflammatory response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of interferon-gamma-mediated signaling pathway TAS
    Traceable Author Statement
    more info
     
    response to antibiotic IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to hydroperoxide IEA
    Inferred from Electronic Annotation
    more info
     
    response to interleukin-12 IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to lipopolysaccharide ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    response to tumor necrosis factor IDA
    Inferred from Direct Assay
    more info
    PubMed 
    signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    tumor necrosis factor-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    tyrosine phosphorylation of STAT protein IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    tyrosine phosphorylation of STAT protein ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    tyrosine phosphorylation of Stat1 protein IEA
    Inferred from Electronic Annotation
    more info
     
    tyrosine phosphorylation of Stat3 protein IEA
    Inferred from Electronic Annotation
    more info
     
    tyrosine phosphorylation of Stat5 protein IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    caveola ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol TAS
    Traceable Author Statement
    more info
     
    endosome lumen TAS
    Traceable Author Statement
    more info
     
    extrinsic component of cytoplasmic side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    membrane raft ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    nuclear matrix IEA
    Inferred from Electronic Annotation
    more info
     
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    tyrosine-protein kinase JAK2
    Names
    JAK-2
    Janus kinase 2 (a protein tyrosine kinase)
    NP_001309123.1
    NP_001309124.1
    NP_001309125.1
    NP_001309127.1
    NP_001309128.1
    NP_001309133.1
    NP_004963.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_009904.1 RefSeqGene

      Range
      5001..147939
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_612

    mRNA and Protein(s)

    1. NM_001322194.1NP_001309123.1  tyrosine-protein kinase JAK2 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2), along with variants 1, 3, and 4, encodes isoform a.
      Source sequence(s)
      AL158147, AL161450
      UniProtKB/Swiss-Prot
      O60674
      Conserved Domains (6) summary
      cd10379
      Location:386482
      SH2_Jak2; Src homology 2 (SH2) domain in the Janus kinase 2 (Jak2) proteins
      smart00295
      Location:38270
      B41; Band 4.1 homologues
      pfam07714
      Location:8491119
      Pkinase_Tyr; Protein tyrosine kinase
      cd13333
      Location:266386
      FERM_C_JAK2; FERM domain C-lobe of Janus kinase (JAK) 2
      cd05078
      Location:545806
      PTK_Jak2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 2
      cd14205
      Location:8441127
      PTKc_Jak2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 2
    2. NM_001322195.1NP_001309124.1  tyrosine-protein kinase JAK2 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3), along with variants 1, 2, and 4, encodes isoform a.
      Source sequence(s)
      AF058925, AI923337, AK292525, AL161450
      UniProtKB/Swiss-Prot
      O60674
      UniProtKB/TrEMBL
      A8K910
      Conserved Domains (6) summary
      cd10379
      Location:386482
      SH2_Jak2; Src homology 2 (SH2) domain in the Janus kinase 2 (Jak2) proteins
      smart00295
      Location:38270
      B41; Band 4.1 homologues
      pfam07714
      Location:8491119
      Pkinase_Tyr; Protein tyrosine kinase
      cd13333
      Location:266386
      FERM_C_JAK2; FERM domain C-lobe of Janus kinase (JAK) 2
      cd05078
      Location:545806
      PTK_Jak2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 2
      cd14205
      Location:8441127
      PTKc_Jak2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 2
    3. NM_001322196.1NP_001309125.1  tyrosine-protein kinase JAK2 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4), along with variants 1, 2, and 3, encodes isoform a.
      Source sequence(s)
      AL158147, AL161450
      UniProtKB/Swiss-Prot
      O60674
      Conserved Domains (6) summary
      cd10379
      Location:386482
      SH2_Jak2; Src homology 2 (SH2) domain in the Janus kinase 2 (Jak2) proteins
      smart00295
      Location:38270
      B41; Band 4.1 homologues
      pfam07714
      Location:8491119
      Pkinase_Tyr; Protein tyrosine kinase
      cd13333
      Location:266386
      FERM_C_JAK2; FERM domain C-lobe of Janus kinase (JAK) 2
      cd05078
      Location:545806
      PTK_Jak2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 2
      cd14205
      Location:8441127
      PTKc_Jak2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 2
    4. NM_001322198.1NP_001309127.1  tyrosine-protein kinase JAK2 isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6), along with variant 7, encodes isoform c.
      Source sequence(s)
      AL158147, AL161450
      Conserved Domains (5) summary
      smart00219
      Location:444714
      TyrKc; Tyrosine kinase, catalytic domain
      cd05078
      Location:140401
      PTK_Jak2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 2
      cd14205
      Location:439722
      PTKc_Jak2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 2
      pfam07714
      Location:140400
      Pkinase_Tyr; Protein tyrosine kinase
      cl15255
      Location:177
      SH2; Src homology 2 (SH2) domain
    5. NM_001322199.1NP_001309128.1  tyrosine-protein kinase JAK2 isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7), along with variant 6, encodes isoform c
      Source sequence(s)
      AL158147, AL161450
      Conserved Domains (5) summary
      smart00219
      Location:444714
      TyrKc; Tyrosine kinase, catalytic domain
      cd05078
      Location:140401
      PTK_Jak2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 2
      cd14205
      Location:439722
      PTKc_Jak2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 2
      pfam07714
      Location:140400
      Pkinase_Tyr; Protein tyrosine kinase
      cl15255
      Location:177
      SH2; Src homology 2 (SH2) domain
    6. NM_001322204.1NP_001309133.1  tyrosine-protein kinase JAK2 isoform b

      Status: REVIEWED

      Source sequence(s)
      AF058925, AI923337, AK302618, AL161450
      UniProtKB/Swiss-Prot
      O60674
      UniProtKB/TrEMBL
      B4DYV1
      Conserved Domains (7) summary
      smart00219
      Location:700970
      TyrKc; Tyrosine kinase, catalytic domain
      cd10379
      Location:237333
      SH2_Jak2; Src homology 2 (SH2) domain in the Janus kinase 2 (Jak2) proteins
      smart00295
      Location:1121
      B41; Band 4.1 homologues
      cd13333
      Location:117237
      FERM_C_JAK2; FERM domain C-lobe of Janus kinase (JAK) 2
      cd05078
      Location:396657
      PTK_Jak2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 2
      cd14205
      Location:695978
      PTKc_Jak2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 2
      pfam07714
      Location:396656
      Pkinase_Tyr; Protein tyrosine kinase
    7. NM_004972.3NP_004963.1  tyrosine-protein kinase JAK2 isoform a

      See identical proteins and their annotated locations for NP_004963.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1), along with variants 2, 3, and 4, all encode the same isoform (a).
      Source sequence(s)
      AF005216, AF058925, AI923337, AL158147
      Consensus CDS
      CCDS6457.1
      UniProtKB/Swiss-Prot
      O60674
      Related
      ENSP00000371067, OTTHUMP00000021024, ENST00000381652, OTTHUMT00000051609
      Conserved Domains (6) summary
      cd10379
      Location:386482
      SH2_Jak2; Src homology 2 (SH2) domain in the Janus kinase 2 (Jak2) proteins
      smart00295
      Location:38270
      B41; Band 4.1 homologues
      pfam07714
      Location:8491119
      Pkinase_Tyr; Protein tyrosine kinase
      cd13333
      Location:266386
      FERM_C_JAK2; FERM domain C-lobe of Janus kinase (JAK) 2
      cd05078
      Location:545806
      PTK_Jak2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 2
      cd14205
      Location:8441127
      PTKc_Jak2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 2

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p7 Primary Assembly

      Range
      4985086..5128183
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018920.2 Alternate CHM1_1.1

      Range
      4985311..5128355
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)