Display Settings:

Format

Send to:

Choose Destination

Tacr1 tachykinin receptor 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 24807, updated on 19-Jul-2014
Official Symbol
Tacr1provided by RGD
Official Full Name
tachykinin receptor 1provided by RGD
Primary source
RGD:3811
See related
Ensembl:ENSRNOG00000005853
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Also known as
Tac1r
Summary
mediates neuropeptide signaling; may play a role in pain sensitivity; may mediate baroreflex transmission for blood pressure regulation [RGD, Feb 2006]
See Tacr1 in MapViewer
Location:
4q34
Exon count:
5
Annotation release Status Assembly Chr Location
104 current Rnor_5.0 (GCF_000001895.4) 4 NC_005103.3 (177926094..178095041)

Chromosome 4 - NC_005103.3Genomic Context describing neighboring genes Neighboring gene peroxiredoxin-6-like Neighboring gene ubiquitin-40S ribosomal protein S27a-like Neighboring gene uncharacterized LOC102547728 Neighboring gene polymerase (DNA-directed), epsilon 4, accessory subunit

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • , (from )
    ,
  • , (from )
    ,
  • , (from )
    ,
  • , (from )
    ,
  • , (from )
    ,
  • , (from )
    ,
  • , (from )
    ,
  • , (from )
    ,
  • , (from )
    ,
  • Calcium signaling pathway, organism-specific biosystem (from KEGG)
    Calcium signaling pathway, organism-specific biosystemCa2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this...
  • Calcium signaling pathway, conserved biosystem (from KEGG)
    Calcium signaling pathway, conserved biosystemCa2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this...
  • Measles, organism-specific biosystem (from KEGG)
    Measles, organism-specific biosystemMeasles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacteri...
  • Measles, conserved biosystem (from KEGG)
    Measles, conserved biosystemMeasles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacteri...
  • Neuroactive ligand-receptor interaction, organism-specific biosystem (from KEGG)
    Neuroactive ligand-receptor interaction, organism-specific biosystem
    Neuroactive ligand-receptor interaction
  • Neuroactive ligand-receptor interaction, conserved biosystem (from KEGG)
    Neuroactive ligand-receptor interaction, conserved biosystem
    Neuroactive ligand-receptor interaction
  • Peptide GPCRs, organism-specific biosystem (from WikiPathways)
    Peptide GPCRs, organism-specific biosystem
    Peptide GPCRs
  • Spinal Cord Injury, organism-specific biosystem (from WikiPathways)
    Spinal Cord Injury, organism-specific biosystemThis pathway provides an overview of cell types, therapeutic targets, drugs, new proposed targets and pathways implicated in spinal cord injury. Spinal cord injury is a complex multistep process that...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
substance P receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
acute inflammatory response IEP
Inferred from Expression Pattern
more info
PubMed 
aggressive behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
angiotensin-mediated drinking behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
associative learning IMP
Inferred from Mutant Phenotype
more info
PubMed 
behavioral response to pain IMP
Inferred from Mutant Phenotype
more info
PubMed 
eating behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
learning or memory IMP
Inferred from Mutant Phenotype
more info
 
long-term memory IMP
Inferred from Mutant Phenotype
more info
PubMed 
neuropeptide signaling pathway TAS
Traceable Author Statement
more info
PubMed 
operant conditioning IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of action potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of blood pressure IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cytosolic calcium ion concentration IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of epithelial cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of epithelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of hormone secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of leukocyte migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of lymphocyte proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of ossification IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of renal sodium excretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of saliva secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of stress fiber assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of synaptic transmission, GABAergic IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of synaptic transmission, cholinergic IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of uterine smooth muscle contraction IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of vascular permeability IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of vasoconstriction IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of blood pressure IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of smooth muscle cell migration IMP
Inferred from Mutant Phenotype
more info
 
regulation of smooth muscle cell proliferation IMP
Inferred from Mutant Phenotype
more info
 
response to auditory stimulus IDA
Inferred from Direct Assay
more info
PubMed 
response to electrical stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
response to estradiol IEP
Inferred from Expression Pattern
more info
PubMed 
response to ethanol IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to heat IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to hormone IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to morphine IEP
Inferred from Expression Pattern
more info
PubMed 
response to nicotine IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to organic cyclic compound IDA
Inferred from Direct Assay
more info
PubMed 
response to ozone IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to pain ISO
Inferred from Sequence Orthology
more info
 
response to progesterone IEP
Inferred from Expression Pattern
more info
PubMed 
sensory perception of pain IMP
Inferred from Mutant Phenotype
more info
PubMed 
sensory perception of pain TAS
Traceable Author Statement
more info
PubMed 
smooth muscle contraction involved in micturition IMP
Inferred from Mutant Phenotype
more info
PubMed 
sperm ejaculation IMP
Inferred from Mutant Phenotype
more info
PubMed 
tachykinin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
tachykinin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cell body IDA
Inferred from Direct Assay
more info
 
cell periphery ISO
Inferred from Sequence Orthology
more info
 
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
dendrite IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
substance-P receptor
Names
substance-P receptor
SPR
NK-1R
NK-1 receptor
substance p receptor
neurokinin 1 receptor

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012667.2NP_036799.1  substance-P receptor

    See proteins identical to NP_036799.1

    Status: PROVISIONAL

    Source sequence(s)
    J05097
    UniProtKB/Swiss-Prot
    P14600
    Related
    ENSRNOP00000007984, ENSRNOT00000007984
    Conserved Domains (1) summary
    pfam00001
    Location:55305
    Blast Score: 521
    7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_5.0 Primary Assembly

Genomic

  1. NC_005103.3 

    Range
    177926094..178095041
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000072.1 

    Range
    103918032..104086347
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)