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Drd2 dopamine receptor D2 [ Mus musculus (house mouse) ]

Gene ID: 13489, updated on 10-Dec-2014
Official Symbol
Drd2provided by MGI
Official Full Name
dopamine receptor D2provided by MGI
Primary source
MGI:MGI:94924
See related
Ensembl:ENSMUSG00000032259
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D2R; Drd-2
See Drd2 in Epigenomics, MapViewer
Location:
9 A5.3; 9 26.72 cM
Exon count:
8
Annotation release Status Assembly Chr Location
104 current GRCm38.p2 (GCF_000001635.22) 9 NC_000075.6 (49340428..49408168)

Chromosome 9 - NC_000075.6Genomic Context describing neighboring genes Neighboring gene transmembrane protease, serine 5 (spinesin) Neighboring gene predicted gene 4894 Neighboring gene ankyrin repeat and kinase domain containing 1 Neighboring gene tetratricopeptide repeat domain 12

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (12)  1 citation
  • Chemically induced (ENU) (1) 
  • Alcoholism, organism-specific biosystem (from KEGG)
    Alcoholism, organism-specific biosystemAlcoholism, also called dependence on alcohol (ethanol), is a chronic relapsing disorder that is progressive and has serious detrimental health outcomes. As one of the primary mediators of the reward...
  • Alcoholism, conserved biosystem (from KEGG)
    Alcoholism, conserved biosystemAlcoholism, also called dependence on alcohol (ethanol), is a chronic relapsing disorder that is progressive and has serious detrimental health outcomes. As one of the primary mediators of the reward...
  • Amine ligand-binding receptors, organism-specific biosystem (from REACTOME)
    Amine ligand-binding receptors, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Class A/1 (Rhodopsin-like receptors), organism-specific biosystem (from REACTOME)
    Class A/1 (Rhodopsin-like receptors), organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Cocaine addiction, organism-specific biosystem (from KEGG)
    Cocaine addiction, organism-specific biosystemDrug addiction is a chronic, relapsing disorder in which compulsive drug-seeking and drug-taking behavior persists despite serious negative consequences.There is strong evidence that the dopaminergic...
  • Cocaine addiction, conserved biosystem (from KEGG)
    Cocaine addiction, conserved biosystemDrug addiction is a chronic, relapsing disorder in which compulsive drug-seeking and drug-taking behavior persists despite serious negative consequences.There is strong evidence that the dopaminergic...
  • Dopamine receptors, organism-specific biosystem (from REACTOME)
    Dopamine receptors, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Dopaminergic synapse, organism-specific biosystem (from KEGG)
    Dopaminergic synapse, organism-specific biosystemDopamine (DA) is an important and prototypical slow neurotransmitter in the mammalian brain, where it controls a variety of functions including locomotor activity, motivation and reward, learning an...
  • Dopaminergic synapse, conserved biosystem (from KEGG)
    Dopaminergic synapse, conserved biosystemDopamine (DA) is an important and prototypical slow neurotransmitter in the mammalian brain, where it controls a variety of functions including locomotor activity, motivation and reward, learning an...
  • G alpha (i) signalling events, organism-specific biosystem (from REACTOME)
    G alpha (i) signalling events, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
    GPCR downstream signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • GPCR ligand binding, organism-specific biosystem (from REACTOME)
    GPCR ligand binding, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • GPCRs, Other, organism-specific biosystem (from WikiPathways)
    GPCRs, Other, organism-specific biosystemThis pathway was created using the GPCRDB (Horn et al., 1998), http://www.cmbi.kun.nl/7tm/. The groupings are based on the GPCR phylogenetic tree available from the GPCRDB and the training sets used ...
  • Gap junction, organism-specific biosystem (from KEGG)
    Gap junction, organism-specific biosystemGap junctions contain intercellular channels that allow direct communication between the cytosolic compartments of adjacent cells. Each gap junction channel is formed by docking of two 'hemichannels'...
  • Gap junction, conserved biosystem (from KEGG)
    Gap junction, conserved biosystemGap junctions contain intercellular channels that allow direct communication between the cytosolic compartments of adjacent cells. Each gap junction channel is formed by docking of two 'hemichannels'...
  • Hypothetical Network for Drug Addiction, organism-specific biosystem (from WikiPathways)
    Hypothetical Network for Drug Addiction, organism-specific biosystemAdapted from figure 2 in [http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.0040002 Li et al.].
  • Monoamine GPCRs, organism-specific biosystem (from WikiPathways)
    Monoamine GPCRs, organism-specific biosystem
    Monoamine GPCRs
  • Neuroactive ligand-receptor interaction, organism-specific biosystem (from KEGG)
    Neuroactive ligand-receptor interaction, organism-specific biosystem
    Neuroactive ligand-receptor interaction
  • Neuroactive ligand-receptor interaction, conserved biosystem (from KEGG)
    Neuroactive ligand-receptor interaction, conserved biosystem
    Neuroactive ligand-receptor interaction
  • Non-odorant GPCRs, organism-specific biosystem (from WikiPathways)
    Non-odorant GPCRs, organism-specific biosystemListing of non-odorant Mouse GCPRs by coupling.
  • Parkinson's disease, organism-specific biosystem (from KEGG)
    Parkinson's disease, organism-specific biosystemParkinson's disease (PD) is a progressive neurodegenerative movement disorder that results primarily from the death of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNc). Mutations...
  • Rap1 signaling pathway, organism-specific biosystem (from KEGG)
    Rap1 signaling pathway, organism-specific biosystemRap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an ac...
  • Rap1 signaling pathway, conserved biosystem (from KEGG)
    Rap1 signaling pathway, conserved biosystemRap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an ac...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Signaling by GPCR, organism-specific biosystem (from REACTOME)
    Signaling by GPCR, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • cAMP signaling pathway, organism-specific biosystem (from KEGG)
    cAMP signaling pathway, organism-specific biosystemcAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands incl...
  • cAMP signaling pathway, conserved biosystem (from KEGG)
    cAMP signaling pathway, conserved biosystemcAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands incl...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
G-protein coupled receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
dopamine binding IDA
Inferred from Direct Assay
more info
PubMed 
dopamine binding ISO
Inferred from Sequence Orthology
more info
 
dopamine neurotransmitter receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
dopamine neurotransmitter receptor activity ISO
Inferred from Sequence Orthology
more info
 
dopamine neurotransmitter receptor activity, coupled via Gi/Go IDA
Inferred from Direct Assay
more info
PubMed 
dopamine neurotransmitter receptor activity, coupled via Gi/Go IMP
Inferred from Mutant Phenotype
more info
PubMed 
dopamine neurotransmitter receptor activity, coupled via Gi/Go ISO
Inferred from Sequence Orthology
more info
 
drug binding ISO
Inferred from Sequence Orthology
more info
 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
ionotropic glutamate receptor binding ISO
Inferred from Sequence Orthology
more info
 
protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
receptor binding ISO
Inferred from Sequence Orthology
more info
 
signal transducer activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
G-protein coupled receptor internalization ISO
Inferred from Sequence Orthology
more info
 
G-protein coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acid secretion ISO
Inferred from Sequence Orthology
more info
 
activation of protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
adenohypophysis development IMP
Inferred from Mutant Phenotype
more info
PubMed 
adenylate cyclase-inhibiting dopamine receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
adenylate cyclase-inhibiting dopamine receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
adenylate cyclase-inhibiting dopamine receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
adenylate cyclase-inhibiting dopamine receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
adenylate cyclase-modulating G-protein coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
adult behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
adult walking behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
arachidonic acid secretion ISO
Inferred from Sequence Orthology
more info
 
associative learning IMP
Inferred from Mutant Phenotype
more info
PubMed 
auditory behavior ISO
Inferred from Sequence Orthology
more info
 
axonogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
behavioral response to cocaine IMP
Inferred from Mutant Phenotype
more info
PubMed 
behavioral response to ethanol IMP
Inferred from Mutant Phenotype
more info
PubMed 
branching morphogenesis of a nerve IMP
Inferred from Mutant Phenotype
more info
PubMed 
cerebral cortex GABAergic interneuron migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
circadian regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
dopamine metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
dopamine receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
dopamine receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
feeding behavior IGI
Inferred from Genetic Interaction
more info
PubMed 
forebrain development ISO
Inferred from Sequence Orthology
more info
 
grooming behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
 
locomotory behavior IGI
Inferred from Genetic Interaction
more info
PubMed 
locomotory behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
locomotory behavior ISO
Inferred from Sequence Orthology
more info
 
long-term memory ISO
Inferred from Sequence Orthology
more info
 
negative regulation of adenylate cyclase activity ISO
Inferred from Sequence Orthology
more info
 
negative regulation of blood pressure IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of circadian sleep/wake cycle, sleep ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
 
negative regulation of dopamine receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of dopamine receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of dopamine secretion ISO
Inferred from Sequence Orthology
more info
 
negative regulation of insulin secretion ISO
Inferred from Sequence Orthology
more info
 
negative regulation of protein kinase B signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of protein secretion ISO
Inferred from Sequence Orthology
more info
 
negative regulation of synaptic transmission, glutamatergic IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of voltage-gated calcium channel activity ISO
Inferred from Sequence Orthology
more info
 
neurological system process involved in regulation of systemic arterial blood pressure IMP
Inferred from Mutant Phenotype
more info
PubMed 
neuron-neuron synaptic transmission IMP
Inferred from Mutant Phenotype
more info
PubMed 
peristalsis IGI
Inferred from Genetic Interaction
more info
PubMed 
peristalsis IMP
Inferred from Mutant Phenotype
more info
PubMed 
phosphatidylinositol metabolic process ISO
Inferred from Sequence Orthology
more info
 
phospholipase C-activating dopamine receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
phospholipase C-activating dopamine receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
phospholipase C-activating dopamine receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
pigmentation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
positive regulation of G-protein coupled receptor protein signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cytokinesis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of dopamine uptake involved in synaptic transmission IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of growth hormone secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of long-term synaptic potentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of neuroblast proliferation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of receptor internalization ISO
Inferred from Sequence Orthology
more info
 
positive regulation of renal sodium excretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
positive regulation of urine volume IMP
Inferred from Mutant Phenotype
more info
PubMed 
prepulse inhibition IMP
Inferred from Mutant Phenotype
more info
PubMed 
NOT prepulse inhibition IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
regulation of cAMP metabolic process ISO
Inferred from Sequence Orthology
more info
 
regulation of dopamine secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of dopamine uptake involved in synaptic transmission IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of heart rate IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of locomotion involved in locomotory behavior ISO
Inferred from Sequence Orthology
more info
 
regulation of long-term neuronal synaptic plasticity IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of phosphoprotein phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
regulation of potassium ion transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of potassium ion transport ISO
Inferred from Sequence Orthology
more info
 
regulation of sodium ion transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of synapse structural plasticity ISO
Inferred from Sequence Orthology
more info
 
regulation of synaptic transmission IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of synaptic transmission ISO
Inferred from Sequence Orthology
more info
 
regulation of synaptic transmission, GABAergic IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of synaptic transmission, GABAergic IMP
Inferred from Mutant Phenotype
more info
PubMed 
release of sequestered calcium ion into cytosol ISO
Inferred from Sequence Orthology
more info
 
response to amphetamine IGI
Inferred from Genetic Interaction
more info
PubMed 
response to amphetamine IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to cocaine IDA
Inferred from Direct Assay
more info
PubMed 
response to cocaine IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to drug IDA
Inferred from Direct Assay
more info
PubMed 
response to drug IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to drug ISO
Inferred from Sequence Orthology
more info
 
response to histamine ISO
Inferred from Sequence Orthology
more info
 
response to hypoxia ISO
Inferred from Sequence Orthology
more info
 
response to light stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to morphine IMP
Inferred from Mutant Phenotype
more info
PubMed 
sensory perception of smell IMP
Inferred from Mutant Phenotype
more info
PubMed 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
startle response IMP
Inferred from Mutant Phenotype
more info
PubMed 
NOT startle response IMP
Inferred from Mutant Phenotype
more info
PubMed 
synaptic transmission IDA
Inferred from Direct Assay
more info
PubMed 
synaptic transmission, dopaminergic ISO
Inferred from Sequence Orthology
more info
 
temperature homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
visual learning IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
acrosomal vesicle ISO
Inferred from Sequence Orthology
more info
 
axon IDA
Inferred from Direct Assay
more info
PubMed 
axon ISO
Inferred from Sequence Orthology
more info
 
axon terminus ISO
Inferred from Sequence Orthology
more info
 
cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
dendrite IDA
Inferred from Direct Assay
more info
PubMed 
dendrite ISO
Inferred from Sequence Orthology
more info
 
dendritic spine ISO
Inferred from Sequence Orthology
more info
 
endocytic vesicle ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
lateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
membrane ISO
Inferred from Sequence Orthology
more info
 
perikaryon ISO
Inferred from Sequence Orthology
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
postsynaptic density ISO
Inferred from Sequence Orthology
more info
 
sperm flagellum ISO
Inferred from Sequence Orthology
more info
 
synaptic vesicle membrane ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
D(2) dopamine receptor
Names
D(2) dopamine receptor
D2 receptor
dopamine receptor 2
dopamine D2 receptor

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010077.2NP_034207.2  D(2) dopamine receptor

    See proteins identical to NP_034207.2

    Status: PROVISIONAL

    Source sequence(s)
    BC105666
    Consensus CDS
    CCDS40615.1
    UniProtKB/Swiss-Prot
    P61168
    Related
    ENSMUSP00000075170, ENSMUST00000075764
    Conserved Domains (2) summary
    pfam00001
    Location:57427
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    pfam10320
    Location:45233
    7TM_GPCR_Srsx; Serpentine type 7TM GPCR chemoreceptor Srsx

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p2 C57BL/6J

Genomic

  1. NC_000075.6 

    Range
    49340428..49408168
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006509996.1XP_006510059.1  

    UniProtKB/Swiss-Prot
    P61168
    Conserved Domains (2) summary
    pfam00001
    Location:57398
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    pfam10320
    Location:45233
    7TM_GPCR_Srsx; Serpentine type 7TM GPCR chemoreceptor Srsx

Alternate Mm_Celera

Genomic

  1. AC_000031.1 

    Range
    46638220..46705025
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)