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Chrna7 cholinergic receptor, nicotinic, alpha polypeptide 7 [ Mus musculus (house mouse) ]

Gene ID: 11441, updated on 21-Mar-2015
Official Symbol
Chrna7provided by MGI
Official Full Name
cholinergic receptor, nicotinic, alpha polypeptide 7provided by MGI
Primary source
MGI:MGI:99779
See related
Ensembl:ENSMUSG00000030525
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Acra7; alpha7
See Chrna7 in MapViewer
Location:
7 C; 7 34.47 cM
Exon count:
10
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 7 NC_000073.6 (63098692..63212526, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (70243578..70357412, complement)

Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene predicted gene 5333 Neighboring gene predicted gene, 32111 Neighboring gene RIKEN cDNA 4930554H23 gene Neighboring gene OTU domain containing 7A Neighboring gene thyroid hormone receptor associated protein 3 pseudogene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATPase binding ISO
Inferred from Sequence Orthology
more info
 
acetylcholine binding ISO
Inferred from Sequence Orthology
more info
 
acetylcholine receptor activity ISO
Inferred from Sequence Orthology
more info
 
acetylcholine-activated cation-selective channel activity IDA
Inferred from Direct Assay
more info
PubMed 
acetylcholine-activated cation-selective channel activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
acetylcholine-activated cation-selective channel activity ISO
Inferred from Sequence Orthology
more info
 
acetylcholine-gated cation channel activity ISO
Inferred from Sequence Orthology
more info
 
adenylate cyclase binding ISO
Inferred from Sequence Orthology
more info
 
beta-amyloid binding ISO
Inferred from Sequence Orthology
more info
 
chloride channel regulator activity ISO
Inferred from Sequence Orthology
more info
 
drug binding ISO
Inferred from Sequence Orthology
more info
 
extracellular ligand-gated ion channel activity IEA
Inferred from Electronic Annotation
more info
 
ion channel activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
scaffold protein binding ISO
Inferred from Sequence Orthology
more info
 
toxic substance binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
B cell activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
T cell activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
activation of MAPK activity ISO
Inferred from Sequence Orthology
more info
 
associative learning IGI
Inferred from Genetic Interaction
more info
PubMed 
associative learning IMP
Inferred from Mutant Phenotype
more info
PubMed 
behavioral response to ethanol IMP
Inferred from Mutant Phenotype
more info
PubMed 
behavioral response to nicotine IGI
Inferred from Genetic Interaction
more info
PubMed 
calcium ion transport ISO
Inferred from Sequence Orthology
more info
 
cation transmembrane transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
cation transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
cellular calcium ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
cognition ISO
Inferred from Sequence Orthology
more info
 
endocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
generation of ovulation cycle rhythm IMP
Inferred from Mutant Phenotype
more info
PubMed 
ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
ion transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
memory IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of interleukin-1 beta production IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of interleukin-6 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of tumor necrosis factor production IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of tumor necrosis factor production ISO
Inferred from Sequence Orthology
more info
 
neuronal action potential ISO
Inferred from Sequence Orthology
more info
 
ovulation cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of heart rate involved in baroreceptor response to decreased systemic arterial blood pressure IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of membrane potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of membrane potential ISO
Inferred from Sequence Orthology
more info
 
regulation of norepinephrine secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of synaptic transmission, dopaminergic IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to ethanol IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to food IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to hypoxia ISO
Inferred from Sequence Orthology
more info
 
response to nicotine IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to nicotine ISO
Inferred from Sequence Orthology
more info
 
signal transduction ISO
Inferred from Sequence Orthology
more info
 
sperm motility IMP
Inferred from Mutant Phenotype
more info
PubMed 
synaptic transmission, cholinergic IMP
Inferred from Mutant Phenotype
more info
PubMed 
synaptic transmission, cholinergic ISO
Inferred from Sequence Orthology
more info
 
transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
acetylcholine-gated channel complex ISO
Inferred from Sequence Orthology
more info
 
apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
asymmetric synapse ISO
Inferred from Sequence Orthology
more info
 
axon ISO
Inferred from Sequence Orthology
more info
 
cell junction IEA
Inferred from Electronic Annotation
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
dendrite ISO
Inferred from Sequence Orthology
more info
 
dendritic shaft ISO
Inferred from Sequence Orthology
more info
 
dendritic spine ISO
Inferred from Sequence Orthology
more info
 
external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
growth cone ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
membrane raft ISO
Inferred from Sequence Orthology
more info
 
neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
postsynaptic density ISO
Inferred from Sequence Orthology
more info
 
postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
presynaptic membrane ISO
Inferred from Sequence Orthology
more info
 
synapse IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
neuronal acetylcholine receptor subunit alpha-7
Names
neuronal acetylcholine receptor subunit alpha-7
acetylcholine receptor alpha 7 neural
alpha7 nicotinic receptor
alpha7-nAChR

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007390.3NP_031416.3  neuronal acetylcholine receptor subunit alpha-7 precursor

    See proteins identical to NP_031416.3

    Status: VALIDATED

    Source sequence(s)
    AK034208, AK157809, BY727569
    Consensus CDS
    CCDS21329.1
    UniProtKB/Swiss-Prot
    P49582
    UniProtKB/TrEMBL
    Q53YJ9
    UniProtKB/TrEMBL
    Q8CC01
    Related
    ENSMUSP00000032738, ENSMUST00000032738
    Conserved Domains (3) summary
    TIGR00860
    Location:4490
    LIC; Cation transporter family protein
    pfam02931
    Location:26230
    Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
    pfam02932
    Location:237486
    Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000073.6 Reference GRCm38.p3 C57BL/6J

    Range
    63098692..63212526
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. AC_000029.1 Alternate Mm_Celera

    Range
    60542827..60660378
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)