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TSPAN12 tetraspanin 12 [ Homo sapiens (human) ]

Gene ID: 23554, updated on 8-Feb-2015
Official Symbol
TSPAN12provided by HGNC
Official Full Name
tetraspanin 12provided by HGNC
Primary source
HGNC:HGNC:21641
See related
Ensembl:ENSG00000106025; HPRD:15509; MIM:613138; Vega:OTTHUMG00000156980
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EVR5; NET2; NET-2; TM4SF12
Summary
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. [provided by RefSeq, Jul 2008]
Orthologs
See TSPAN12 in MapViewer
Location:
7q31.31
Exon count:
9
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 7 NC_000007.14 (120787320..120858366, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (120427374..120498420, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 3, subunit I pseudogene Neighboring gene potassium channel, voltage gated Shal related subfamily D, member 2 Neighboring gene high mobility group nucleosome binding domain 1 pseudogene 18 Neighboring gene inhibitor of growth family, member 3 Neighboring gene cadherin-like and PC-esterase domain containing 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
NOT Wnt-activated receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
angiogenesis IEA
Inferred from Electronic Annotation
more info
 
cell surface receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of angiogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
retina layer formation ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
integral component of membrane TAS
Traceable Author Statement
more info
PubMed 
integral component of plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
membrane TAS
Traceable Author Statement
more info
PubMed 
Preferred Names
tetraspanin-12
Names
tetraspanin-12
tetraspan NET-2
transmembrane 4 superfamily member 12
tspan-12

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_023203.1 RefSeqGene

    Range
    5001..75804
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_012338.3NP_036470.1  tetraspanin-12

    See proteins identical to NP_036470.1

    Status: REVIEWED

    Source sequence(s)
    AY358703, BC031265, BF338835, BI964728
    Consensus CDS
    CCDS5777.1
    UniProtKB/TrEMBL
    A0A024R740
    UniProtKB/Swiss-Prot
    O95859
    Related
    ENSP00000222747, OTTHUMP00000211223, ENST00000222747, OTTHUMT00000346951
    Conserved Domains (2) summary
    cd03157
    Location:116218
    TM4SF12_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF12_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
    pfam00335
    Location:9244
    Tetraspannin; Tetraspanin family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38 Primary Assembly

    Range
    120787320..120858366
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005250239.1XP_005250296.1  

    See proteins identical to XP_005250296.1

    UniProtKB/TrEMBL
    A0A024R740
    UniProtKB/Swiss-Prot
    O95859
    Conserved Domains (2) summary
    cd03157
    Location:116218
    TM4SF12_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF12_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
    pfam00335
    Location:9244
    Tetraspannin; Tetraspanin family

Alternate CHM1_1.1

Genomic

  1. NC_018918.2 Alternate CHM1_1.1

    Range
    120360669..120431498
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000139.1 Alternate HuRef

    Range
    114790536..114861356
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)