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    HVCN1 hydrogen voltage gated channel 1 [ Homo sapiens (human) ]

    Gene ID: 84329, updated on 15-Jun-2016
    Official Symbol
    HVCN1provided by HGNC
    Official Full Name
    hydrogen voltage gated channel 1provided by HGNC
    Primary source
    HGNC:HGNC:28240
    See related
    Ensembl:ENSG00000122986 HPRD:17507; MIM:611227; Vega:OTTHUMG00000169530
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HV1; VSOP
    Summary
    This gene encodes a voltage-gated protein channel protein expressed more highly in certain cells of the immune system. Phagocytic cells produce superoxide anions which require this channel protein, and in B cells this same process facilitates antibody production. This same channel protein, however, can also regulate functions in other cells including spermatozoa. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
    Orthologs
    Location:
    12q24.11
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 12 NC_000012.12 (110648686..110704945, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (111086491..111130276, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene VPS29, retromer complex component Neighboring gene RAD9 checkpoint clamp component B Neighboring gene PTC7 protein phosphatase homolog Neighboring gene tectonic family member 1 Neighboring gene protein phosphatase 1 catalytic subunit gamma Neighboring gene ribosomal protein L29 pseudogene 25

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Fertilization, organism-specific biosystem (from REACTOME)
      Fertilization, organism-specific biosystemMammalian fertilization comprises sperm migration through the female reproductive tract, biochemical and morphological changes to sperm, and sperm-egg interaction in the oviduct. Although the broad c...
    • Reproduction, organism-specific biosystem (from REACTOME)
      Reproduction, organism-specific biosystemHuman reproduction mixes the genomes of two individuals creating a new organism. The offspring individuals produced by sexual reproduction differ from their parents and from their siblings. Reproduct...
    • Sperm Motility And Taxes, organism-specific biosystem (from REACTOME)
      Sperm Motility And Taxes, organism-specific biosystemA series of receptor signaling pathways potentially govern chemical communication between sperm and egg, chemotactically guiding incoming sperm towards the oocyte. Though several substances are confi...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC15619

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    voltage-gated cation channel activity TAS
    Traceable Author Statement
    more info
     
    voltage-gated proton channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    voltage-gated proton channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    Process Evidence Code Pubs
    cellular response to pH IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to zinc ion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    proton transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    proton transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    regulation of ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    response to pH ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    response to zinc ion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to zinc ion ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    sperm-egg recognition TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    integral component of membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    Preferred Names
    voltage-gated hydrogen channel 1
    Names
    hydrogen voltage-gated channel 1
    voltage sensor domain-only protein

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001040107.1NP_001035196.1  voltage-gated hydrogen channel 1 isoform 1

      See identical proteins and their annotated locations for NP_001035196.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the shorter protein (isoform 1). Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC144522, BP375483, DB310328
      Consensus CDS
      CCDS31900.1
      UniProtKB/Swiss-Prot
      Q96D96
      Conserved Domains (1) summary
      pfam00520
      Location:141216
      Ion_trans; Ion transport protein
    2. NM_001256413.1NP_001243342.1  voltage-gated hydrogen channel 1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon compared to variant 1. The resulting protein (isoform 2) is shorter and has a distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AC144522, AK293543
      Consensus CDS
      CCDS58278.1
      UniProtKB/Swiss-Prot
      Q96D96
      Related
      ENSP00000412052, OTTHUMP00000241456, ENST00000439744, OTTHUMT00000404654
      Conserved Domains (1) summary
      pfam00520
      Location:121196
      Ion_trans; Ion transport protein
    3. NM_032369.3NP_115745.2  voltage-gated hydrogen channel 1 isoform 1

      See identical proteins and their annotated locations for NP_115745.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      BC009731, BP369986, DB310328
      Consensus CDS
      CCDS31900.1
      UniProtKB/Swiss-Prot
      Q96D96
      Related
      ENSP00000242607, OTTHUMP00000241454, ENST00000242607, OTTHUMT00000404652
      Conserved Domains (1) summary
      pfam00520
      Location:141216
      Ion_trans; Ion transport protein

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p7 Primary Assembly

      Range
      110648686..110704945 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011538846.2XP_011537148.1  

      See identical proteins and their annotated locations for XP_011537148.1

      UniProtKB/Swiss-Prot
      Q96D96
      Conserved Domains (1) summary
      pfam00520
      Location:141216
      Ion_trans; Ion transport protein
    2. XM_017020026.1XP_016875515.1  

    3. XM_011538847.1XP_011537149.1  

      See identical proteins and their annotated locations for XP_011537149.1

      UniProtKB/Swiss-Prot
      Q96D96
      Related
      ENSP00000349181, OTTHUMP00000241455, ENST00000356742, OTTHUMT00000404653
      Conserved Domains (1) summary
      pfam00520
      Location:141216
      Ion_trans; Ion transport protein
    4. XM_011538842.2XP_011537144.1  

      See identical proteins and their annotated locations for XP_011537144.1

      Conserved Domains (1) summary
      pfam00520
      Location:188263
      Ion_trans; Ion transport protein
    5. XM_011538839.2XP_011537141.1  

      See identical proteins and their annotated locations for XP_011537141.1

      Conserved Domains (1) summary
      pfam00520
      Location:188263
      Ion_trans; Ion transport protein
    6. XM_005253948.2XP_005254005.1  

      See identical proteins and their annotated locations for XP_005254005.1

      UniProtKB/Swiss-Prot
      Q96D96
      Conserved Domains (1) summary
      pfam00520
      Location:141216
      Ion_trans; Ion transport protein
    7. XM_011538840.2XP_011537142.1  

      See identical proteins and their annotated locations for XP_011537142.1

      Conserved Domains (1) summary
      pfam00520
      Location:188263
      Ion_trans; Ion transport protein
    8. XM_011538838.1XP_011537140.1  

      See identical proteins and their annotated locations for XP_011537140.1

      Conserved Domains (1) summary
      pfam00520
      Location:188263
      Ion_trans; Ion transport protein
    9. XM_011538845.1XP_011537147.1  

      See identical proteins and their annotated locations for XP_011537147.1

      UniProtKB/Swiss-Prot
      Q96D96
      Related
      ENSP00000449601, OTTHUMP00000241453, ENST00000548312, OTTHUMT00000404651
      Conserved Domains (1) summary
      pfam00520
      Location:141216
      Ion_trans; Ion transport protein
    10. XM_011538844.2XP_011537146.1  

      See identical proteins and their annotated locations for XP_011537146.1

      Conserved Domains (1) summary
      pfam00520
      Location:188263
      Ion_trans; Ion transport protein
    11. XM_011538841.2XP_011537143.1  

      See identical proteins and their annotated locations for XP_011537143.1

      Conserved Domains (1) summary
      pfam00520
      Location:188263
      Ion_trans; Ion transport protein
    12. XM_017020027.1XP_016875516.1  

    Alternate CHM1_1.1

    Genomic

    1. NC_018923.2 Alternate CHM1_1.1

      Range
      111054153..111095269 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)