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    FKBP53 peptidyl-prolyl cis-trans isomerase FKBP53 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 828637, updated on 5-Jul-2015
    Gene symbol
    FKBP53
    Gene description
    peptidyl-prolyl cis-trans isomerase FKBP53
    Primary source
    TAIR:AT4G25340
    Locus tag
    AT4G25340
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATFKBP53; FK506 BINDING PROTEIN 53; FKBP53; T30C3.20; T30C3_20
    Summary
    Encodes a member of the FKBP-type immunophilin family that functions as a histone chaparone. Binds to 18S rDNA and represses its expression.
    See FKBP53 in MapViewer
    Location:
    chromosome: 4
    Exon count:
    11
    Sequence:
    Chromosome: 4; NC_003075.7 (12959442..12962699, complement)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene AT hook motif DNA-binding family protein Neighboring gene hypothetical protein Neighboring gene protein SHORT HYPOCOTYL UNDER BLUE1 Neighboring gene protein trichome birefringence-like 18

    Products Interactant Other Gene Complex Source Pubs Description
    NM_001203907.1
    NM_118666.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    FK506 binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    FK506 binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    histone binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    peptidyl-prolyl cis-trans isomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    peptidyl-prolyl cis-trans isomerase activity IEA
    Inferred from Electronic Annotation
    more info
     
    peptidyl-prolyl cis-trans isomerase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    RNA methylation RCA
    inferred from Reviewed Computational Analysis
    more info
    PubMed 
    histone peptidyl-prolyl isomerization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    nucleosome assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    peptidyl-proline modification IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    response to endoplasmic reticulum stress RCA
    inferred from Reviewed Computational Analysis
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISM
    Inferred from Sequence Model
    more info
     
    Names
    peptidyl-prolyl cis-trans isomerase FKBP53
    NP_001190836.1
    • FK506 BINDING PROTEIN 53 (FKBP53); CONTAINS InterPro DOMAIN/s: Peptidyl-prolyl cis-trans isomerase, FKBP-type (InterPro:IPR001179); BEST Arabidopsis thaliana protein match is: FKBP-like peptidyl-prolyl cis-trans isomerase family protein (TAIR:AT5G05420.1).
    NP_567717.1
    • FK506 BINDING PROTEIN 53 (FKBP53); FUNCTIONS IN: FK506 binding, peptidyl-prolyl cis-trans isomerase activity, histone binding; INVOLVED IN: nucleosome assembly; LOCATED IN: nucleolus, nucleus; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Peptidyl-prolyl cis-trans isomerase, FKBP-type (InterPro:IPR001179); BEST Arabidopsis thaliana protein match is: FKBP-like peptidyl-prolyl cis-trans isomerase family protein (TAIR:AT5G05420.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      12959442..12962699
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_118666.2NP_567717.1  peptidyl-prolyl cis-trans isomerase FKBP53 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_567717.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q93ZG9
      Conserved Domains (1) summary
      pfam00254
      Location:384474
      FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
    2. NM_001203907.1NP_001190836.1  peptidyl-prolyl cis-trans isomerase FKBP53 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001190836.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F4JSK5
      Conserved Domains (1) summary
      pfam00254
      Location:384433
      FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase