Format

Send to:

Choose Destination

Links from PubMed

    • Showing Current items.

    Avpr2 arginine vasopressin receptor 2 [ Mus musculus (house mouse) ]

    Gene ID: 12000, updated on 26-Jun-2016
    Official Symbol
    Avpr2provided by MGI
    Official Full Name
    arginine vasopressin receptor 2provided by MGI
    Primary source
    MGI:MGI:88123
    See related
    Ensembl:ENSMUSG00000031390 Vega:OTTMUSG00000017671
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    DI1; DIR; ND1; V2R; ADHR; VPV2R
    Summary
    This gene encodes a member of the G-protein coupled receptor 1 family and the vasopressin/oxytocin receptor subfamily. The encoded protein is an arginine vasopressin receptor which, when stimulated, activates the Gs protein/adenylyl cyclase signaling cascade and is involved in water and electrolyte homeostasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]
    Orthologs
    Location:
    X A7.3; X 37.46 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) X NC_000086.7 (73891798..73894428)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) X NC_000086.6 (71137441..71139766)

    Chromosome X - NC_000086.7Genomic Context describing neighboring genes Neighboring gene PDZ domain containing 4 Neighboring gene L1 cell adhesion molecule Neighboring gene Rho GTPase activating protein 4 Neighboring gene N(alpha)-acetyltransferase 10, NatA catalytic subunit Neighboring gene renin binding protein

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Markers

    Homology

    Clone Names

    • MGC124213, MGC124214, MGC124215, MGC129321

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    G-protein coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    peptide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    signal transducer activity IEA
    Inferred from Electronic Annotation
    more info
     
    vasopressin receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    vasopressin receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    G-protein coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    I-kappaB kinase/NF-kappaB signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to hormone stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    interferon-gamma production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of renal sodium excretion ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of urine volume ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of blood pressure ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of systemic arterial blood pressure ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of vasoconstriction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    regulation of systemic arterial blood pressure by vasopressin IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    response to cytokine IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to peptide IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    vasopressin V2 receptor
    Names
    antidiuretic hormone receptor
    nephrogenic diabetes insipidus
    renal-type arginine vasopressin receptor

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001276298.1NP_001263227.1  vasopressin V2 receptor isoform b

      See identical proteins and their annotated locations for NP_001263227.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region which results in a frameshift, compared to variant 1. The encoded isoform (b) is shorter and has a distinct C-terminus, compared to isoform a.
      Source sequence(s)
      AL672002
      Consensus CDS
      CCDS72396.1
      UniProtKB/TrEMBL
      Q3SWS4
      Related
      ENSMUSP00000099011, OTTMUSP00000019965, ENSMUST00000101470, OTTMUST00000043662
      Conserved Domains (1) summary
      pfam00001
      Location:60241
      7tm_1; 7 transmembrane receptor (rhodopsin family)
    2. NM_001276299.1NP_001263228.1  vasopressin V2 receptor isoform c

      See identical proteins and their annotated locations for NP_001263228.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice site in the coding region, compared to variant 1. It encodes a shorter protein (isoform c) compared to isoform a.
      Source sequence(s)
      AL672002, BC107005
      Consensus CDS
      CCDS72397.1
      UniProtKB/TrEMBL
      Q3KNZ4
      Related
      ENSMUSP00000110037, OTTMUSP00000019966, ENSMUST00000114395, OTTMUST00000043663
      Conserved Domains (1) summary
      pfam00001
      Location:10114
      7tm_1; 7 transmembrane receptor (rhodopsin family)
    3. NM_019404.2NP_062277.1  vasopressin V2 receptor isoform a

      See identical proteins and their annotated locations for NP_062277.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AL672002, BC104729
      Consensus CDS
      CCDS30216.1
      UniProtKB/Swiss-Prot
      O88721
      UniProtKB/TrEMBL
      Q3SWS1
      Related
      ENSMUSP00000033765, OTTMUSP00000019256, ENSMUST00000033765, OTTMUST00000042869
      Conserved Domains (1) summary
      pfam00001
      Location:61325
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000086.7 Reference GRCm38.p4 C57BL/6J

      Range
      73891798..73894428
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006527756.3XP_006527819.1  

      See identical proteins and their annotated locations for XP_006527819.1

      UniProtKB/Swiss-Prot
      O88721
      UniProtKB/TrEMBL
      Q3SWS1
      Conserved Domains (1) summary
      pfam00001
      Location:61325
      7tm_1; 7 transmembrane receptor (rhodopsin family)
    2. XM_017318365.1XP_017173854.1