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TREML1 triggering receptor expressed on myeloid cells-like 1 [ Homo sapiens (human) ]

Gene ID: 340205, updated on 19-Jul-2014
Official Symbol
TREML1provided by HGNC
Official Full Name
triggering receptor expressed on myeloid cells-like 1provided by HGNC
Primary source
HGNC:20434
Locus tag
UNQ1825/PRO3438
See related
Ensembl:ENSG00000161911; HPRD:11645; MIM:609714; Vega:OTTHUMG00000016231
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TLT1; TLT-1; PRO3438; GLTL1825; dJ238O23.3
Summary
This gene encodes a member of the triggering receptor expressed on myeloid cells-like (TREM) family. The encoded protein is a type 1 single Ig domain orphan receptor localized to the alpha-granule membranes of platelets. The encoded protein is involved in platelet aggregation, inflammation, and cellular activation and has been linked to Gray platelet syndrome. Alternative splicing results in multiple transcript variants [provided by RefSeq, Nov 2012]
See TREML1 in Epigenomics, MapViewer
Location:
6p21.1
Exon count :
6
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 6 NC_000006.12 (41149260..41154349, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (41116998..41122087, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene O-acyl-ADP-ribose deacylase 1 Neighboring gene nuclear transcription factor Y, alpha Neighboring gene adenylate cyclase 10 (soluble) pseudogene 1 Neighboring gene triggering receptor expressed on myeloid cells 2 Neighboring gene triggering receptor expressed on myeloid cells-like 2

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120-treated vaginal epithelial cells show upregulation of triggering receptor expressed on myeloid cells-like 1 (TREML1) expression as compared to untreated control PubMed

Go to the HIV-1, Human Protein Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
calcium-mediated signaling IDA
Inferred from Direct Assay
more info
PubMed 
innate immune response NAS
Non-traceable Author Statement
more info
PubMed 
platelet activation IEA
Inferred from Electronic Annotation
more info
 
platelet activation IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
cell surface IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane NAS
Non-traceable Author Statement
more info
PubMed 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
platelet alpha granule IDA
Inferred from Direct Assay
more info
PubMed 
platelet alpha granule IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
trem-like transcript 1 protein
Names
trem-like transcript 1 protein
triggering receptor expressed on myeloid cells-like protein 1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271807.1NP_001258736.1  trem-like transcript 1 protein isoform b precursor

    See proteins identical to NP_001258736.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an exon in the coding region which results in a frameshift, compared to variant 1. The encoded isoform (b) is shorter and has a distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AL133404, AY358357, BQ023322, DW009745
    Consensus CDS
    CCDS64421.1
    UniProtKB/Swiss-Prot
    Q86YW5
    Related
    ENSP00000362219, OTTHUMP00000267885, ENST00000373127, OTTHUMT00000458287
    Conserved Domains (1) summary
    cl11960
    Location:25113
    Blast Score: 147
    Ig; Immunoglobulin domain
  2. NM_001271808.1NP_001258737.1  trem-like transcript 1 protein isoform c precursor

    See proteins identical to NP_001258737.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an in-frame exon in the coding region, compared to variant 1. The encoded isoform (c) is shorter compared to isoform a.
    Source sequence(s)
    AL133404, AY358357, BC100946, BQ023322, DW009745
    Consensus CDS
    CCDS64420.1
    UniProtKB/Swiss-Prot
    Q86YW5
  3. NM_178174.3NP_835468.1  trem-like transcript 1 protein isoform a precursor

    See proteins identical to NP_835468.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AF534822, AL133404, AY358357, BQ023322, DW009745
    Consensus CDS
    CCDS4851.1
    UniProtKB/Swiss-Prot
    Q86YW5
    Conserved Domains (1) summary
    cl11960
    Location:25113
    Blast Score: 147
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000006.12 

    Range
    41149260..41154349
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006715085.1XP_006715148.1  

    Conserved Domains (1) summary
    cl11960
    Location:25113
    Blast Score: 147
    Ig; Immunoglobulin domain

Alternate HuRef

Genomic

  1. AC_000138.1 

    Range
    40834784..40839873
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018917.2 

    Range
    41119893..41124982
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

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