Display Settings:

Format

Send to:

Choose Destination
    • Showing Current items.

    TNK1 tyrosine kinase, non-receptor, 1 [ Homo sapiens (human) ]

    Gene ID: 8711, updated on 30-Jun-2015
    Official Symbol
    TNK1provided by HGNC
    Official Full Name
    tyrosine kinase, non-receptor, 1provided by HGNC
    Primary source
    HGNC:HGNC:11940
    See related
    Ensembl:ENSG00000174292; HPRD:09730; MIM:608076; Vega:OTTHUMG00000178174
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    The protein encoded by this gene belongs to the tyrosine protein kinase family. Tyrosine protein kinases are important regulators of intracellular signal transduction pathways, mediating cellular proliferation, survival, and development. This gene is highly expressed in fetal tissues and at lower levels in few adult tissues, thus may function in signaling pathways utilized broadly during fetal development, and more selectively in adult tissues. It plays a negative regulatory role in the Ras-Raf1-MAPK pathway, and knockout mice have been shown to develop spontaneous tumors, suggesting a role as a tumor suppressor gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
    Orthologs
    See TNK1 in Epigenomics, MapViewer
    Location:
    17p13.1
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 17 NC_000017.11 (7380559..7389774)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (7284293..7293093)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene potassium channel tetramerization domain containing 11 Neighboring gene transmembrane protein 95 Neighboring gene TMEM256-PLSCR3 readthrough (NMD candidate) Neighboring gene phospholipid scramblase 3 Neighboring gene transmembrane protein 256 Neighboring gene neuroligin 2

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Replication interactions

    Interaction Pubs
    Knockdown of tyrosine kinase, non-receptor, 1 (TNK1) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

    Go to the HIV-1, Human Interaction Database

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC46193

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    hormone receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    non-membrane spanning protein tyrosine kinase activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein tyrosine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    signal transducer activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    negative regulation of Ras protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of cell growth IEA
    Inferred from Electronic Annotation
    more info
     
    peptidyl-tyrosine autophosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein phosphorylation TAS
    Traceable Author Statement
    more info
    PubMed 
    regulation of cell proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    transmembrane receptor protein tyrosine kinase signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    extrinsic component of cytoplasmic side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    non-receptor tyrosine-protein kinase TNK1
    Names
    CD38 negative kinase 1
    TNK1
    NP_001238831.1
    NP_003976.2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001251902.1NP_001238831.1  non-receptor tyrosine-protein kinase TNK1 isoform 1

      See identical proteins and their annotated locations for NP_001238831.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AI810287, AK225403, AK310684, BC035782, DA089305, U43408
      Consensus CDS
      CCDS58510.1
      UniProtKB/Swiss-Prot
      Q13470
      Related
      ENSP00000459799, OTTHUMP00000258691, ENST00000576812, OTTHUMT00000440832
      Conserved Domains (6) summary
      cd09539
      Location:667
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      smart00326
      Location:385441
      SH3; Src homology 3 domains
      pfam07714
      Location:116377
      Pkinase_Tyr; Protein tyrosine kinase
      cd14328
      Location:624663
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cl21453
      Location:120379
      PKc_like; Catalytic domain of the Protein Kinase superfamily
      cl21463
      Location:594637
      UBA_like_SF; UBA domain-like superfamily
    2. NM_003985.4NP_003976.2  non-receptor tyrosine-protein kinase TNK1 isoform 2

      See identical proteins and their annotated locations for NP_003976.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame acceptor splice site at an internal coding exon compared to variant 1. This results in a shorter isoform (2) missing a 5 aa protein segment compared to isoform 1.
      Source sequence(s)
      AI810287, AK225403, AK310684, BC035782, DA089305
      Consensus CDS
      CCDS45602.1
      UniProtKB/Swiss-Prot
      Q13470
      Related
      ENSP00000458834, OTTHUMP00000258692, ENST00000570896, OTTHUMT00000440833
      Conserved Domains (6) summary
      cd09539
      Location:667
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      pfam07714
      Location:116377
      Pkinase_Tyr; Protein tyrosine kinase
      cd14328
      Location:619658
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cl17036
      Location:396435
      SH3; Src Homology 3 domain superfamily
      cl21453
      Location:120379
      PKc_like; Catalytic domain of the Protein Kinase superfamily
      cl21463
      Location:589632
      UBA_like_SF; UBA domain-like superfamily

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p2 Primary Assembly

      Range
      7380559..7389774
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011524045.1XP_011522347.1  

      See identical proteins and their annotated locations for XP_011522347.1

      Conserved Domains (6) summary
      cd09539
      Location:667
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      pfam07714
      Location:116377
      Pkinase_Tyr; Protein tyrosine kinase
      cd14328
      Location:619658
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cl17036
      Location:396435
      SH3; Src Homology 3 domain superfamily
      cl21453
      Location:120379
      PKc_like; Catalytic domain of the Protein Kinase superfamily
      cl21463
      Location:589632
      UBA_like_SF; UBA domain-like superfamily
    2. XM_011524047.1XP_011522349.1  

      Conserved Domains (4) summary
      cd09539
      Location:667
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      pfam07714
      Location:116377
      Pkinase_Tyr; Protein tyrosine kinase
      cl17036
      Location:396435
      SH3; Src Homology 3 domain superfamily
      cl21453
      Location:120379
      PKc_like; Protein Kinases, catalytic domain
    3. XM_011524046.1XP_011522348.1  

      Conserved Domains (6) summary
      cd09539
      Location:667
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      pfam07714
      Location:116377
      Pkinase_Tyr; Protein tyrosine kinase
      cd14328
      Location:617656
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cl17036
      Location:396435
      SH3; Src Homology 3 domain superfamily
      cl21453
      Location:120379
      PKc_like; Protein Kinases, catalytic domain
      cl21463
      Location:587630
      UBA_like_SF; UBA domain-like superfamily
    4. XM_011524048.1XP_011522350.1  

      Conserved Domains (5) summary
      pfam07714
      Location:1220
      Pkinase_Tyr; Protein tyrosine kinase
      cd14328
      Location:462501
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cl17036
      Location:239278
      SH3; Src Homology 3 domain superfamily
      cl21453
      Location:7222
      PKc_like; Protein Kinases, catalytic domain
      cl21463
      Location:432475
      UBA_like_SF; UBA domain-like superfamily

    Alternate CHM1_1.1

    Genomic

    1. NC_018928.2 Alternate CHM1_1.1

      Range
      7293383..7302185
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)