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    NLRC5 NLR family, CARD domain containing 5 [ Homo sapiens (human) ]

    Gene ID: 84166, updated on 27-Jun-2015
    Official Symbol
    NLRC5provided by HGNC
    Official Full Name
    NLR family, CARD domain containing 5provided by HGNC
    Primary source
    HGNC:HGNC:29933
    See related
    Ensembl:ENSG00000140853; HPRD:14831; MIM:613537; Vega:OTTHUMG00000133470
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NOD4; NOD27; CLR16.1
    Summary
    This gene encodes a member of the caspase recruitment domain-containing NLR family. This gene plays a role in cytokine response and antiviral immunity through its inhibition of NF-kappa-B activation and negative regulation of type I interferon signaling pathways. [provided by RefSeq, Oct 2011]
    Orthologs
    See NLRC5 in Epigenomics, MapViewer
    Location:
    16q13
    Exon count:
    55
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 16 NC_000016.10 (56989547..57083526)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (57023469..57117438)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 Neighboring gene cholesteryl ester transfer protein, plasma Neighboring gene cilia and flagella associated protein 69 pseudogene Neighboring gene copine II Neighboring gene uncharacterized LOC105371289 Neighboring gene family with sequence similarity 192, member A

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    Genome-wide association study in a Swedish population yields support for greater CNV and MHC involvement in schizophrenia compared with bipolar disorder.
    NHGRI GWA Catalog
    Genome-wide association study of clinical dimensions of schizophrenia: polygenic effect on disorganized symptoms.
    NHGRI GWA Catalog
    Genomic study in Mexicans identifies a new locus for triglycerides and refines European lipid loci.
    NHGRI GWA Catalog

    Replication interactions

    Interaction Pubs
    Knockdown of NLR family, CARD domain containing 5 (NLRC5) by siRNA enhances the early stages of HIV-1 replication in HeLa-CD4 cells infected with viral pseudotypes HIV89.6R and HIV8.2N PubMed

    Go to the HIV-1, Human Interaction Database

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • FLJ21709, FLJ39711

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    RNA polymerase II core promoter sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    protein NLRC5
    Names
    protein NLRC5
    NOD-like receptor C5
    caterpiller protein 16.1
    nucleotide-binding oligomerization domain protein 4
    nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 5
    nucleotide-binding oligomerization domains 27

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_030337.1 RefSeqGene

      Range
      5001..71451
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_032206.4NP_115582.4  protein NLRC5

      See identical proteins and their annotated locations for NP_115582.4

      Status: REVIEWED

      Source sequence(s)
      AA722775, AC023825, AF389420, AK025362, AK074133, BI061907, BM463398, BM993764, BX640842, DB293035
      Consensus CDS
      CCDS10773.1
      UniProtKB/TrEMBL
      Q6MZW3
      UniProtKB/Swiss-Prot
      Q86WI3
      UniProtKB/TrEMBL
      Q9H6Y0
      Related
      ENSP00000389739, ENST00000436936
      Conserved Domains (6) summary
      smart00382
      Location:221365
      AAA; ATPases associated with a variety of cellular activities
      COG4886
      Location:731936
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      cd00116
      Location:15221822
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      pfam05729
      Location:222383
      NACHT; NACHT domain
      pfam13855
      Location:15801646
      LRR_8; Leucine rich repeat
      sd00033
      Location:15241545
      LRR_RI; leucine-rich repeat [structural motif]

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p2 Primary Assembly

      Range
      56989547..57083526
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006721297.1XP_006721360.1  

      See identical proteins and their annotated locations for XP_006721360.1

      UniProtKB/Swiss-Prot
      Q86WI3
      Related
      ENSP00000262510, OTTHUMP00000164675, ENST00000262510, OTTHUMT00000257346
      Conserved Domains (6) summary
      smart00382
      Location:221365
      AAA; ATPases associated with a variety of cellular activities
      COG4886
      Location:731936
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      cd00116
      Location:15221822
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      pfam05729
      Location:222383
      NACHT; NACHT domain
      pfam13855
      Location:15801646
      LRR_8; Leucine rich repeat
      sd00033
      Location:15241545
      LRR_RI; leucine-rich repeat [structural motif]
    2. XM_005256193.1XP_005256250.1  

      See identical proteins and their annotated locations for XP_005256250.1

      UniProtKB/Swiss-Prot
      Q86WI3
      Conserved Domains (6) summary
      smart00382
      Location:221365
      AAA; ATPases associated with a variety of cellular activities
      COG4886
      Location:731936
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      cd00116
      Location:15221822
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      pfam05729
      Location:222383
      NACHT; NACHT domain
      pfam13855
      Location:15801646
      LRR_8; Leucine rich repeat
      sd00033
      Location:15241545
      LRR_RI; leucine-rich repeat [structural motif]
    3. XM_005256195.1XP_005256252.1  

      Conserved Domains (5) summary
      smart00382
      Location:221365
      AAA; ATPases associated with a variety of cellular activities
      COG4886
      Location:731936
      COG4886; Leucine-rich repeat (LRR) protein [Function unknown]
      pfam05729
      Location:222383
      NACHT; NACHT domain
      sd00033
      Location:15231788
      LRR_RI; leucine-rich repeats, ribonuclease inhibitor (RI)-like subfamily
      cl22710
      Location:15211821
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    4. XM_005256197.1XP_005256254.1  

      UniProtKB/Swiss-Prot
      Q86WI3
      Related
      ENSP00000441727, OTTHUMP00000238063, ENST00000539144, OTTHUMT00000398389
      Conserved Domains (5) summary
      smart00382
      Location:221365
      AAA; ATPases associated with a variety of cellular activities
      COG4886
      Location:731936
      COG4886; Leucine-rich repeat (LRR) protein [Function unknown]
      pfam05729
      Location:222383
      NACHT; NACHT domain
      sd00033
      Location:14951760
      LRR_RI; leucine-rich repeats, ribonuclease inhibitor (RI)-like subfamily
      cl22710
      Location:14931793
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    5. XM_006721298.1XP_006721361.1  

      Conserved Domains (5) summary
      smart00382
      Location:221365
      AAA; ATPases associated with a variety of cellular activities
      COG4886
      Location:731936
      COG4886; Leucine-rich repeat (LRR) protein [Function unknown]
      pfam05729
      Location:222383
      NACHT; NACHT domain
      sd00033
      Location:14941759
      LRR_RI; leucine-rich repeats, ribonuclease inhibitor (RI)-like subfamily
      cl22710
      Location:14921792
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    6. XM_005256196.1XP_005256253.1  

      Conserved Domains (4) summary
      smart00382
      Location:221365
      AAA; ATPases associated with a variety of cellular activities
      pfam05729
      Location:222383
      NACHT; NACHT domain
      sd00033
      Location:14961761
      LRR_RI; leucine-rich repeats, ribonuclease inhibitor (RI)-like subfamily
      cl22710
      Location:14941794
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    7. XM_006721300.2XP_006721363.1  

      Conserved Domains (4) summary
      smart00382
      Location:221365
      AAA; ATPases associated with a variety of cellular activities
      COG4886
      Location:731936
      COG4886; Leucine-rich repeat (LRR) protein [Function unknown]
      pfam05729
      Location:222383
      NACHT; NACHT domain
      cl22710
      Location:6901069
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    8. XM_011523375.1XP_011521677.1  

      Conserved Domains (5) summary
      smart00382
      Location:221365
      AAA; ATPases associated with a variety of cellular activities
      COG4886
      Location:731936
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      cd00116
      Location:6901069
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      pfam05729
      Location:222383
      NACHT; NACHT domain
      sd00033
      Location:716743
      LRR_RI; leucine-rich repeat [structural motif]
    9. XM_011523374.1XP_011521676.1  

      Conserved Domains (5) summary
      smart00382
      Location:221365
      AAA; ATPases associated with a variety of cellular activities
      COG4886
      Location:731936
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      cd00116
      Location:6901069
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      pfam05729
      Location:222383
      NACHT; NACHT domain
      sd00033
      Location:716743
      LRR_RI; leucine-rich repeat [structural motif]
    10. XM_005256199.2XP_005256256.1  

      Conserved Domains (4) summary
      smart00382
      Location:221365
      AAA; ATPases associated with a variety of cellular activities
      COG4886
      Location:731936
      COG4886; Leucine-rich repeat (LRR) protein [Function unknown]
      pfam05729
      Location:222383
      NACHT; NACHT domain
      cl22710
      Location:6901069
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    11. XM_005256201.2XP_005256258.1  

      Conserved Domains (4) summary
      smart00382
      Location:221365
      AAA; ATPases associated with a variety of cellular activities
      COG4886
      Location:731936
      COG4886; Leucine-rich repeat (LRR) protein [Function unknown]
      pfam05729
      Location:222383
      NACHT; NACHT domain
      cl22710
      Location:6901069
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    12. XM_005256194.2XP_005256251.1  

      See identical proteins and their annotated locations for XP_005256251.1

      UniProtKB/Swiss-Prot
      Q86WI3
      Conserved Domains (6) summary
      smart00382
      Location:221365
      AAA; ATPases associated with a variety of cellular activities
      COG4886
      Location:731936
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      cd00116
      Location:15221822
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      pfam05729
      Location:222383
      NACHT; NACHT domain
      pfam13855
      Location:15801646
      LRR_8; Leucine rich repeat
      sd00033
      Location:15241545
      LRR_RI; leucine-rich repeat [structural motif]
    13. XM_011523373.1XP_011521675.1  

      See identical proteins and their annotated locations for XP_011521675.1

      Conserved Domains (6) summary
      smart00382
      Location:221365
      AAA; ATPases associated with a variety of cellular activities
      COG4886
      Location:731936
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      cd00116
      Location:15221822
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      pfam05729
      Location:222383
      NACHT; NACHT domain
      pfam13855
      Location:15801646
      LRR_8; Leucine rich repeat
      sd00033
      Location:15241545
      LRR_RI; leucine-rich repeat [structural motif]
    14. XM_011523376.1XP_011521678.1  

      Conserved Domains (4) summary
      COG4886
      Location:19224
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      cd00116
      Location:8101110
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      pfam13855
      Location:868934
      LRR_8; Leucine rich repeat
      sd00033
      Location:812833
      LRR_RI; leucine-rich repeat [structural motif]

    RNA

    1. XR_429734.1 RNA Sequence

    2. XR_933458.1 RNA Sequence

    3. XR_429733.1 RNA Sequence

    Alternate CHM1_1.1

    Genomic

    1. NC_018927.2 Alternate CHM1_1.1

      Range
      58458904..58524899
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)