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Lox lysyl oxidase [ Rattus norvegicus (Norway rat) ]

Gene ID: 24914, updated on 19-Jul-2014
Official Symbol
Loxprovided by RGD
Official Full Name
lysyl oxidaseprovided by RGD
Primary source
RGD:3015
See related
Ensembl:ENSRNOG00000014426
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Also known as
Rrg1; H-rev142
Summary
enzyme involved in the catalysis of the reaction required for cross-linking of collagen and elastin fibers [RGD, Feb 2006]
See Lox in MapViewer
Location:
18q11
Exon count :
10
Annotation release Status Assembly Chr Location
104 current Rnor_5.0 (GCF_000001895.4) 18 NC_005117.3 (46713533..46791367, complement)

Chromosome 18 - NC_005117.3Genomic Context describing neighboring genes Neighboring gene serum response factor binding protein 1 Neighboring gene microRNA mir-664-1 Neighboring gene similar to ribosomal protein S3A Neighboring gene zinc finger protein 474 Neighboring gene similar to FLJ32921 protein Neighboring gene glycerol kinase-like 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
copper ion binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein-lysine 6-oxidase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein-lysine 6-oxidase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein-lysine 6-oxidase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
blood vessel development IEA
Inferred from Electronic Annotation
more info
 
blood vessel development ISO
Inferred from Sequence Orthology
more info
 
collagen fibril organization IDA
Inferred from Direct Assay
more info
PubMed 
collagen fibril organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
collagen fibril organization ISO
Inferred from Sequence Orthology
more info
 
elastic fiber assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
elastic fiber assembly ISO
Inferred from Sequence Orthology
more info
 
lung development IEA
Inferred from Electronic Annotation
more info
 
lung development ISO
Inferred from Sequence Orthology
more info
 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
response to drug IEP
Inferred from Expression Pattern
more info
PubMed 
response to hormone IDA
Inferred from Direct Assay
more info
PubMed 
response to steroid hormone IDA
Inferred from Direct Assay
more info
PubMed 
wound healing IEP
Inferred from Expression Pattern
more info
PubMed 
wound healing IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
collagen trimer IEA
Inferred from Electronic Annotation
more info
 
collagen trimer ISO
Inferred from Sequence Orthology
more info
 
extracellular space IEA
Inferred from Electronic Annotation
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
proteinaceous extracellular matrix IDA
Inferred from Direct Assay
more info
PubMed 
proteinaceous extracellular matrix ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
protein-lysine 6-oxidase
Names
protein-lysine 6-oxidase
Lysyl oxidase (an H-rev gene with its expression down-regulated in HRAS-transformed rat 208F fibroblasts)
NP_058757.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017061.2NP_058757.1  protein-lysine 6-oxidase precursor

    See proteins identical to NP_058757.1

    Status: PROVISIONAL

    Source sequence(s)
    BC078861
    UniProtKB/Swiss-Prot
    P16636
    Related
    ENSRNOP00000019844, ENSRNOT00000019844
    Conserved Domains (1) summary
    pfam01186
    Location:207411
    Blast Score: 1022
    Lysyl_oxidase; Lysyl oxidase

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_5.0 Primary Assembly

Genomic

  1. NC_005117.3 

    Range
    46713533..46791367
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006254714.1XP_006254776.1  

    See proteins identical to XP_006254776.1

    UniProtKB/Swiss-Prot
    P16636
    Related
    ENSRNOP00000065314, ENSRNOT00000074226
    Conserved Domains (1) summary
    pfam01186
    Location:207411
    Blast Score: 1022
    Lysyl_oxidase; Lysyl oxidase
  2. XM_006254713.1XP_006254775.1  

    See proteins identical to XP_006254775.1

    UniProtKB/Swiss-Prot
    P16636
    Conserved Domains (1) summary
    pfam01186
    Location:207411
    Blast Score: 1022
    Lysyl_oxidase; Lysyl oxidase
  3. XM_006254715.1XP_006254777.1  

    Conserved Domains (1) summary
    pfam01186
    Location:207410
    Blast Score: 1020
    Lysyl_oxidase; Lysyl oxidase

Alternate Rn_Celera

Genomic

  1. AC_000086.1 

    Range
    44155712..44229997
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

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