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Pparg peroxisome proliferator activated receptor gamma [ Mus musculus (house mouse) ]

Gene ID: 19016, updated on 19-Dec-2014
Official Symbol
Ppargprovided by MGI
Official Full Name
peroxisome proliferator activated receptor gammaprovided by MGI
Primary source
MGI:MGI:97747
See related
Ensembl:ENSMUSG00000000440
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Nr1c3; PPARgamma; PPAR-gamma; PPARgamma2; PPAR-gamma2
See Pparg in Epigenomics, MapViewer
Location:
6 E3-F1; 6 53.41 cM
Exon count:
16
Annotation release Status Assembly Chr Location
104 current GRCm38.p2 (GCF_000001635.22) 6 NC_000072.6 (115360894..115490404)

Chromosome 6 - NC_000072.6Genomic Context describing neighboring genes Neighboring gene synapsin II Neighboring gene transcriptional adaptor 1 pseudogene Neighboring gene tissue inhibitor of metalloproteinase 4 Neighboring gene predicted gene, 36301 Neighboring gene predicted gene, 36355

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
DNA binding IPI
Inferred from Physical Interaction
more info
PubMed 
DNA binding ISO
Inferred from Sequence Orthology
more info
 
RNA polymerase II regulatory region DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IDA
Inferred from Direct Assay
more info
PubMed 
WW domain binding ISO
Inferred from Sequence Orthology
more info
PubMed 
activating transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
arachidonic acid binding IDA
Inferred from Direct Assay
more info
PubMed 
chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
drug binding ISO
Inferred from Sequence Orthology
more info
 
enzyme binding ISO
Inferred from Sequence Orthology
more info
 
estrogen receptor binding ISO
Inferred from Sequence Orthology
more info
 
ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity TAS
Traceable Author Statement
more info
PubMed 
ligand-dependent nuclear receptor transcription coactivator activity IDA
Inferred from Direct Assay
more info
PubMed 
ligand-dependent nuclear receptor transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein phosphatase binding ISO
Inferred from Sequence Orthology
more info
 
retinoid X receptor binding ISO
Inferred from Sequence Orthology
more info
 
contributes_to sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
sequence-specific DNA binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
sequence-specific DNA binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
steroid hormone receptor activity IEA
Inferred from Electronic Annotation
more info
 
transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
transcription regulatory region DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
transcription regulatory region DNA binding ISO
Inferred from Sequence Orthology
more info
 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
activation of cysteine-type endopeptidase activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
brown fat cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
cell fate commitment IGI
Inferred from Genetic Interaction
more info
PubMed 
cell maturation ISO
Inferred from Sequence Orthology
more info
 
cellular response to insulin stimulus ISO
Inferred from Sequence Orthology
more info
 
cellular response to lithium ion IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to organic cyclic compound IDA
Inferred from Direct Assay
more info
PubMed 
epithelial cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
fat cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
fat cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
fatty acid oxidation ISO
Inferred from Sequence Orthology
more info
 
glucose homeostasis ISO
Inferred from Sequence Orthology
more info
 
inflammatory response TAS
Traceable Author Statement
more info
PubMed 
intracellular receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
lipoprotein transport ISO
Inferred from Sequence Orthology
more info
 
long-chain fatty acid transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
low-density lipoprotein particle receptor biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
monocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of acute inflammatory response ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell growth ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cellular response to insulin stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cholesterol storage ISO
Inferred from Sequence Orthology
more info
 
negative regulation of collagen biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cytokine production IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of interferon-gamma-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
negative regulation of macrophage derived foam cell differentiation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of pancreatic stellate cell proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of peptide hormone secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of receptor biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of sequestering of triglyceride ISO
Inferred from Sequence Orthology
more info
 
negative regulation of smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of telomerase activity ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
peroxisome proliferator activated receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
placenta development IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of fat cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of fat cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of fat cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of fat cell differentiation ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of fatty acid oxidation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of oligodendrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of phagocytosis, engulfment ISO
Inferred from Sequence Orthology
more info
 
positive regulation of sequence-specific DNA binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
regulation of blood pressure ISO
Inferred from Sequence Orthology
more info
 
regulation of fat cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of fat cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of fat cell differentiation ISO
Inferred from Sequence Orthology
more info
 
regulation of lipid metabolic process ISO
Inferred from Sequence Orthology
more info
 
regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
regulation of transcription from RNA polymerase II promoter TAS
Traceable Author Statement
more info
PubMed 
regulation of transcription involved in cell fate commitment IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
response to lipid IDA
Inferred from Direct Assay
more info
PubMed 
response to low-density lipoprotein particle ISO
Inferred from Sequence Orthology
more info
 
response to retinoic acid IDA
Inferred from Direct Assay
more info
PubMed 
response to retinoic acid ISO
Inferred from Sequence Orthology
more info
 
signal transduction ISO
Inferred from Sequence Orthology
more info
 
steroid hormone mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
white fat cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
RNA polymerase II transcription factor complex ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
cytosol ISO
Inferred from Sequence Orthology
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
peroxisome proliferator-activated receptor gamma
Names
peroxisome proliferator-activated receptor gamma
nuclear receptor subfamily 1 group C member 3
peroxisome proliferator activated receptor gamma 2
peroxisome proliferator activated receptor gamma 4

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001127330.1NP_001120802.1  peroxisome proliferator-activated receptor gamma isoform 1

    See proteins identical to NP_001120802.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR and 5' coding region compared to variant 2. Variant 1 encodes isoform 1, which has a shorter, N-terminus compared to isoform 2.
    Source sequence(s)
    AC153828, AC171970, CN701591, CT010340
    Consensus CDS
    CCDS51876.1
    UniProtKB/TrEMBL
    M1VPI1
    UniProtKB/Swiss-Prot
    P37238
    UniProtKB/TrEMBL
    Q4FJR2
    Related
    ENSMUSP00000131962, ENSMUST00000171644
    Conserved Domains (3) summary
    cd06932
    Location:207474
    NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
    cd06965
    Location:108191
    NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
    pfam12577
    Location:178
    PPARgamma_N; PPAR gamma N-terminal region
  2. NM_011146.3NP_035276.2  peroxisome proliferator-activated receptor gamma isoform 2

    See proteins identical to NP_035276.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) encodes the longer isoform (2).
    Source sequence(s)
    AC153828, AC171970, CT010340, U09138
    Consensus CDS
    CCDS20439.1
    UniProtKB/Swiss-Prot
    P37238
    UniProtKB/TrEMBL
    Q4FJR2
    UniProtKB/TrEMBL
    Q6GU14
    Related
    ENSMUSP00000000450, ENSMUST00000000450
    Conserved Domains (3) summary
    cd06932
    Location:237504
    NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
    cd06965
    Location:138221
    NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
    pfam12577
    Location:31108
    PPARgamma_N; PPAR gamma N-terminal region

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p2 C57BL/6J

Genomic

  1. NC_000072.6 

    Range
    115360894..115490404
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006505743.1XP_006505806.1  

    See proteins identical to XP_006505806.1

    UniProtKB/TrEMBL
    M1VPI1
    UniProtKB/Swiss-Prot
    P37238
    Conserved Domains (3) summary
    cd06932
    Location:207474
    NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
    cd06965
    Location:108191
    NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
    pfam12577
    Location:178
    PPARgamma_N; PPAR gamma N-terminal region
  2. XM_006505744.1XP_006505807.1  

    See proteins identical to XP_006505807.1

    UniProtKB/TrEMBL
    M1VPI1
    UniProtKB/Swiss-Prot
    P37238
    Conserved Domains (3) summary
    cd06932
    Location:207474
    NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
    cd06965
    Location:108191
    NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
    pfam12577
    Location:178
    PPARgamma_N; PPAR gamma N-terminal region
  3. XM_006505742.1XP_006505805.1  

    See proteins identical to XP_006505805.1

    UniProtKB/TrEMBL
    M1VPI1
    UniProtKB/Swiss-Prot
    P37238
    Conserved Domains (3) summary
    cd06932
    Location:207474
    NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
    cd06965
    Location:108191
    NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
    pfam12577
    Location:178
    PPARgamma_N; PPAR gamma N-terminal region
  4. XM_006505737.1XP_006505800.1  

    See proteins identical to XP_006505800.1

    Conserved Domains (3) summary
    cd06932
    Location:232499
    NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
    cd06965
    Location:133216
    NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
    pfam12577
    Location:26103
    PPARgamma_N; PPAR gamma N-terminal region
  5. XM_006505739.1XP_006505802.1  

    See proteins identical to XP_006505802.1

    Conserved Domains (3) summary
    cd06932
    Location:232499
    NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
    cd06965
    Location:133216
    NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
    pfam12577
    Location:26103
    PPARgamma_N; PPAR gamma N-terminal region
  6. XM_006505738.1XP_006505801.1  

    See proteins identical to XP_006505801.1

    Conserved Domains (3) summary
    cd06932
    Location:232499
    NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
    cd06965
    Location:133216
    NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
    pfam12577
    Location:26103
    PPARgamma_N; PPAR gamma N-terminal region
  7. XM_006505741.1XP_006505804.1  

    See proteins identical to XP_006505804.1

    UniProtKB/TrEMBL
    M1VPI1
    UniProtKB/Swiss-Prot
    P37238
    Conserved Domains (3) summary
    cd06932
    Location:207474
    NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
    cd06965
    Location:108191
    NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
    pfam12577
    Location:178
    PPARgamma_N; PPAR gamma N-terminal region
  8. XM_006505740.1XP_006505803.1  

    See proteins identical to XP_006505803.1

    UniProtKB/TrEMBL
    M1VPI1
    UniProtKB/Swiss-Prot
    P37238
    Conserved Domains (3) summary
    cd06932
    Location:207474
    NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
    cd06965
    Location:108191
    NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
    pfam12577
    Location:178
    PPARgamma_N; PPAR gamma N-terminal region
  9. XM_006505745.1XP_006505808.1  

    Conserved Domains (1) summary
    cd06932
    Location:25292
    NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors

Alternate Mm_Celera

Genomic

  1. AC_000028.1 

    Range
    117199637..117329691
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)