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    Foxo3 forkhead box O3 [ Mus musculus (house mouse) ]

    Gene ID: 56484, updated on 5-Jul-2015
    Official Symbol
    Foxo3provided by MGI
    Official Full Name
    forkhead box O3provided by MGI
    Primary source
    MGI:MGI:1890081
    See related
    Ensembl:ENSMUSG00000048756; Vega:OTTMUSG00000020929
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fkhr2; C76856; FKHRL1; Foxo3a; 1110048B16Rik; 2010203A17Rik
    Orthologs
    See Foxo3 in Epigenomics, MapViewer
    Location:
    10 B2; 10 22.79 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    105 current GRCm38.p3 (GCF_000001635.23) 10 NC_000076.6 (42181845..42276746, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (41905592..41996548, complement)

    Chromosome 10 - NC_000076.6Genomic Context describing neighboring genes Neighboring gene armadillo repeat containing 2 Neighboring gene RIKEN cDNA 1700016J18 gene Neighboring gene predicted gene, 40630 Neighboring gene thymine DNA glycosylase pseudogene Neighboring gene predicted gene, 38485 Neighboring gene predicted gene, 33333 Neighboring gene lactation elevated 1

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    DNA damage response, signal transduction by p53 class mediator IDA
    Inferred from Direct Assay
    more info
    PubMed 
    anatomical structure morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    antral ovarian follicle growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cellular response to oxidative stress IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extrinsic apoptotic signaling pathway in absence of ligand IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    glucose homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    initiation of primordial ovarian follicle growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of canonical Wnt signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of transcription from RNA polymerase II promoter IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    neuronal stem cell maintenance IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    oocyte maturation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ovulation from ovarian follicle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of erythrocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription from RNA polymerase II promoter IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of neural precursor cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of reactive oxygen species metabolic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of translation ISO
    Inferred from Sequence Orthology
    more info
     
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    forkhead box protein O3
    Names
    forkhead box O3a
    forkhead protein FKHR2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019740.2NP_062714.1  forkhead box protein O3

      See identical proteins and their annotated locations for NP_062714.1

      Status: PROVISIONAL

      Source sequence(s)
      AC116179, AC140402
      Consensus CDS
      CCDS23810.1
      UniProtKB/Swiss-Prot
      Q9WVH4
      Related
      ENSMUSP00000050683, OTTMUSP00000022930, ENSMUST00000056974, OTTMUST00000049478
      Conserved Domains (1) summary
      cd00059
      Location:156236
      FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p3 C57BL/6J

    Genomic

    1. NC_000076.6 Reference GRCm38.p3 C57BL/6J

      Range
      42181845..42276746
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006512806.1XP_006512869.1  

      See identical proteins and their annotated locations for XP_006512869.1

      UniProtKB/Swiss-Prot
      Q9WVH4
      Related
      ENSMUSP00000101141, OTTMUSP00000022929, ENSMUST00000105502, OTTMUST00000049477
      Conserved Domains (1) summary
      cd00059
      Location:156236
      FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...

    Alternate Mm_Celera

    Genomic

    1. AC_000032.1 Alternate Mm_Celera

      Range
      43062294..43153032
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)