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FASN fatty acid synthase [ Homo sapiens (human) ]

Gene ID: 2194, updated on 7-Jul-2014
Official Symbol
FASNprovided by HGNC
Official Full Name
fatty acid synthaseprovided by HGNC
Primary source
HGNC:3594
See related
Ensembl:ENSG00000169710; HPRD:02567; MIM:600212; Vega:OTTHUMG00000178527
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FAS; OA-519; SDR27X1
Summary
The enzyme encoded by this gene is a multifunctional protein. Its main function is to catalyze the synthesis of palmitate from acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated fatty acids. In some cancer cell lines, this protein has been found to be fused with estrogen receptor-alpha (ER-alpha), in which the N-terminus of FAS is fused in-frame with the C-terminus of ER-alpha. [provided by RefSeq, Jul 2008]
See FASN in Epigenomics, MapViewer
Location:
17q25
Exon count :
43
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 17 NC_000017.11 (82078338..82098230, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (80036214..80056106, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene G protein pathway suppressor 1 Neighboring gene dihydrouridine synthase 1-like (S. cerevisiae) Neighboring gene coiled-coil domain containing 57 Neighboring gene solute carrier family 16 (monocarboxylate transporter), member 3 Neighboring gene microRNA 6787

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify fatty acid synthase (FASN), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into Staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Gag, Pr55 gag Tandem affinity purification and mass spectrometry analysis identify fatty acid synthase (FASN), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into Staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Nef, p27 nef Tandem affinity purification and mass spectrometry analysis identify fatty acid synthase (FASN), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into Staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
pol gag-pol Tandem affinity purification and mass spectrometry analysis identify fatty acid synthase (FASN), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into Staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed

Go to the HIV-1, Human Protein Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity IEA
Inferred from Electronic Annotation
more info
 
3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity IEA
Inferred from Electronic Annotation
more info
 
3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity IEA
Inferred from Electronic Annotation
more info
 
3-oxoacyl-[acyl-carrier-protein] synthase activity IEA
Inferred from Electronic Annotation
more info
 
NADPH binding IEA
Inferred from Electronic Annotation
more info
 
[acyl-carrier-protein] S-acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
[acyl-carrier-protein] S-malonyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
drug binding IEA
Inferred from Electronic Annotation
more info
 
enoyl-[acyl-carrier-protein] reductase (NADPH, A-specific) activity IEA
Inferred from Electronic Annotation
more info
 
enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity IEA
Inferred from Electronic Annotation
more info
 
fatty acid synthase activity TAS
Traceable Author Statement
more info
 
myristoyl-[acyl-carrier-protein] hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
oleoyl-[acyl-carrier-protein] hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
palmitoyl-[acyl-carrier-protein] hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
poly(A) RNA binding IDA
Inferred from Direct Assay
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acetyl-CoA metabolic process IEA
Inferred from Electronic Annotation
more info
 
cellular lipid metabolic process TAS
Traceable Author Statement
more info
 
cellular response to interleukin-4 IEA
Inferred from Electronic Annotation
more info
 
energy reserve metabolic process TAS
Traceable Author Statement
more info
 
fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
fatty acid metabolic process TAS
Traceable Author Statement
more info
PubMed 
long-chain fatty-acyl-CoA biosynthetic process TAS
Traceable Author Statement
more info
 
osteoblast differentiation IDA
Inferred from Direct Assay
more info
PubMed 
pantothenate metabolic process TAS
Traceable Author Statement
more info
 
positive regulation of cellular metabolic process TAS
Traceable Author Statement
more info
 
small molecule metabolic process TAS
Traceable Author Statement
more info
 
triglyceride biosynthetic process TAS
Traceable Author Statement
more info
 
vitamin metabolic process TAS
Traceable Author Statement
more info
 
water-soluble vitamin metabolic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
extracellular vesicular exosome IDA
Inferred from Direct Assay
more info
PubMed 
glycogen granule IEA
Inferred from Electronic Annotation
more info
 
melanosome IEA
Inferred from Electronic Annotation
more info
 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
 
Preferred Names
fatty acid synthase
Names
fatty acid synthase
short chain dehydrogenase/reductase family 27X, member 1
NP_004095.4

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004104.4NP_004095.4  fatty acid synthase

    See proteins identical to NP_004095.4

    Status: REVIEWED

    Source sequence(s)
    BC007267, BC021544, BC063242, S80437
    Consensus CDS
    CCDS11801.1
    UniProtKB/Swiss-Prot
    P49327
    Related
    ENSP00000304592, OTTHUMP00000259630, ENST00000306749, OTTHUMT00000442369
    Conserved Domains (12) summary
    pfam00698
    Location:493810
    Blast Score: 995
    Acyl_transf_1; Acyl transferase domain
    cd05195
    Location:15661854
    Blast Score: 925
    enoyl_red; enoyl reductase of polyketide synthase
    cd08954
    Location:18762112
    Blast Score: 847
    KR_1_FAS_SDR_x; beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 1, complex (x) SDRs
    smart00823
    Location:21112179
    Blast Score: 172
    PKS_PP; Phosphopantetheine attachment site
    smart00829
    Location:15641854
    Blast Score: 1057
    PKS_ER; Enoylreductase
    COG3321
    Location:11022
    Blast Score: 1402
    COG3321; Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]
    cd00833
    Location:2404
    Blast Score: 1399
    PKS; polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or ...
    pfam00106
    Location:19012053
    Blast Score: 403
    adh_short; short chain dehydrogenase
    pfam00975
    Location:22422487
    Blast Score: 355
    Thioesterase; Thioesterase domain
    pfam08242
    Location:12431342
    Blast Score: 150
    Methyltransf_12; Methyltransferase domain
    pfam13847
    Location:12391383
    Blast Score: 113
    Methyltransf_31; Methyltransferase domain
    pfam14765
    Location:8741106
    Blast Score: 213
    PS-DH; Polyketide synthase dehydratase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000017.11 

    Range
    82078338..82098230
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000149.1 

    Range
    75436168..75456057
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018928.2 

    Range
    80122440..80142272
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

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