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SULF2 sulfatase 2 [ Homo sapiens (human) ]

Gene ID: 55959, updated on 7-Aug-2014
Official Symbol
SULF2provided by HGNC
Official Full Name
sulfatase 2provided by HGNC
Primary source
HGNC:20392
Locus tag
RP5-1049G16.1
See related
Ensembl:ENSG00000196562; HPRD:18130; MIM:610013; Vega:OTTHUMG00000032675
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HSULF-2
Summary
Heparan sulfate proteoglycans (HSPGs) act as coreceptors for numerous heparin-binding growth factors and cytokines and are involved in cell signaling. Heparan sulfate 6-O-endosulfatases, such as SULF2, selectively remove 6-O-sulfate groups from heparan sulfate. This activity modulates the effects of heparan sulfate by altering binding sites for signaling molecules (Dai et al., 2005 [PubMed 16192265]).[supplied by OMIM, Mar 2008]
See SULF2 in Epigenomics, MapViewer
Location:
20q12-q13.2
Exon count:
24
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 20 NC_000020.11 (47657406..47786629, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (46286150..46415360, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein L35a pseudogene Neighboring gene nuclear receptor coactivator 3 Neighboring gene ribosomal protein S3A pseudogene Neighboring gene RNA, 5S ribosomal pseudogene 486 Neighboring gene spermidine synthase pseudogene 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Common variation in GPC5 is associated with acquired nephrotic syndrome.
NHGRI GWA Catalog
Genome-wide association scan of the time to onset of attention deficit hyperactivity disorder.
NHGRI GWA Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ44488, FLJ90554, KIAA1247, MGC126411, DKFZp313E091

Gene Ontology Provided by GOA

Function Evidence Code Pubs
N-acetylglucosamine-6-sulfatase activity IDA
Inferred from Direct Assay
more info
PubMed 
N-acetylglucosamine-6-sulfatase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
arylsulfatase activity IDA
Inferred from Direct Assay
more info
PubMed 
arylsulfatase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
bone development ISS
Inferred from Sequence or Structural Similarity
more info
 
cartilage development ISS
Inferred from Sequence or Structural Similarity
more info
 
chondrocyte development ISS
Inferred from Sequence or Structural Similarity
more info
 
embryonic skeletal system development ISS
Inferred from Sequence or Structural Similarity
more info
 
esophagus smooth muscle contraction ISS
Inferred from Sequence or Structural Similarity
more info
 
glial cell-derived neurotrophic factor receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
glomerular basement membrane development ISS
Inferred from Sequence or Structural Similarity
more info
 
glomerular filtration ISS
Inferred from Sequence or Structural Similarity
more info
 
heparan sulfate proteoglycan metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
heparan sulfate proteoglycan metabolic process NAS
Non-traceable Author Statement
more info
PubMed 
innervation ISS
Inferred from Sequence or Structural Similarity
more info
 
kidney development ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of fibroblast growth factor receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation vascular endothelial growth factor production ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
Golgi stack IEA
Inferred from Electronic Annotation
more info
 
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space NAS
Non-traceable Author Statement
more info
PubMed 
plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
Preferred Names
extracellular sulfatase Sulf-2
Names
extracellular sulfatase Sulf-2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001161841.1NP_001155313.1  extracellular sulfatase Sulf-2 isoform a precursor

    See proteins identical to NP_001155313.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Both variants 1 and 3 encode the same isoform (a).
    Source sequence(s)
    AI824415, AL550624, AY101176, BC110539, CD673642, CR749319
    Consensus CDS
    CCDS13408.1
    UniProtKB/Swiss-Prot
    Q8IWU5
    Related
    ENSP00000418290, OTTHUMP00000031226, ENST00000484875, OTTHUMT00000079610
    Conserved Domains (4) summary
    COG3119
    Location:43395
    Blast Score: 340
    AslA; Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]
    pfam00884
    Location:44375
    Blast Score: 357
    Sulfatase; Sulfatase
    pfam12548
    Location:529665
    Blast Score: 536
    DUF3740; Sulfatase protein
    cl19157
    Location:364389
    Blast Score: 112
    Sulfatase; Sulfatase
  2. NM_018837.3NP_061325.1  extracellular sulfatase Sulf-2 isoform a precursor

    See proteins identical to NP_061325.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a). Both variants 1 and 3 encode the same isoform.
    Source sequence(s)
    AB033073, AI824415, BC110539, CD673642
    Consensus CDS
    CCDS13408.1
    UniProtKB/Swiss-Prot
    Q8IWU5
    Conserved Domains (4) summary
    COG3119
    Location:43395
    Blast Score: 340
    AslA; Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]
    pfam00884
    Location:44375
    Blast Score: 357
    Sulfatase; Sulfatase
    pfam12548
    Location:529665
    Blast Score: 536
    DUF3740; Sulfatase protein
    cl19157
    Location:364389
    Blast Score: 112
    Sulfatase; Sulfatase
  3. NM_198596.2NP_940998.2  extracellular sulfatase Sulf-2 isoform b precursor

    See proteins identical to NP_940998.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and includes an alternate in-frame splice site in the 3' coding region, compared to variant 1, resulting in an isoform (b) that is shorter than isoform a.
    Source sequence(s)
    AI824415, AL550624, AY101176, AY358461, CD673642
    Consensus CDS
    CCDS13409.2
    UniProtKB/Swiss-Prot
    Q8IWU5
    Related
    ENSP00000418442, OTTHUMP00000215977, ENST00000467815, OTTHUMT00000356466
    Conserved Domains (4) summary
    COG3119
    Location:43395
    Blast Score: 340
    AslA; Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]
    pfam00884
    Location:44375
    Blast Score: 357
    Sulfatase; Sulfatase
    pfam12548
    Location:529665
    Blast Score: 536
    DUF3740; Sulfatase protein
    cl19157
    Location:364389
    Blast Score: 112
    Sulfatase; Sulfatase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000020.11 

    Range
    47657406..47786629
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006723828.1XP_006723891.1  

    See proteins identical to XP_006723891.1

    Conserved Domains (4) summary
    COG3119
    Location:43395
    Blast Score: 340
    AslA; Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]
    pfam00884
    Location:44375
    Blast Score: 357
    Sulfatase; Sulfatase
    pfam12548
    Location:529666
    Blast Score: 524
    DUF3740; Sulfatase protein
    cl19157
    Location:364389
    Blast Score: 112
    Sulfatase; Sulfatase
  2. XM_006723829.1XP_006723892.1  

    See proteins identical to XP_006723892.1

    Conserved Domains (4) summary
    COG3119
    Location:43395
    Blast Score: 340
    AslA; Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]
    pfam00884
    Location:44375
    Blast Score: 357
    Sulfatase; Sulfatase
    pfam12548
    Location:529666
    Blast Score: 524
    DUF3740; Sulfatase protein
    cl19157
    Location:364389
    Blast Score: 112
    Sulfatase; Sulfatase
  3. XM_006723830.1XP_006723893.1  

    See proteins identical to XP_006723893.1

    UniProtKB/Swiss-Prot
    Q8IWU5
    Conserved Domains (4) summary
    COG3119
    Location:43395
    Blast Score: 340
    AslA; Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]
    pfam00884
    Location:44375
    Blast Score: 357
    Sulfatase; Sulfatase
    pfam12548
    Location:529665
    Blast Score: 536
    DUF3740; Sulfatase protein
    cl19157
    Location:364389
    Blast Score: 112
    Sulfatase; Sulfatase
  4. XM_005260458.1XP_005260515.1  

    See proteins identical to XP_005260515.1

    UniProtKB/Swiss-Prot
    Q8IWU5
    Conserved Domains (4) summary
    COG3119
    Location:43395
    Blast Score: 340
    AslA; Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]
    pfam00884
    Location:44375
    Blast Score: 357
    Sulfatase; Sulfatase
    pfam12548
    Location:529665
    Blast Score: 536
    DUF3740; Sulfatase protein
    cl19157
    Location:364389
    Blast Score: 112
    Sulfatase; Sulfatase
  5. XM_006723827.1XP_006723890.1  

    See proteins identical to XP_006723890.1

    Conserved Domains (4) summary
    COG3119
    Location:43395
    Blast Score: 340
    AslA; Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]
    pfam00884
    Location:44375
    Blast Score: 357
    Sulfatase; Sulfatase
    pfam12548
    Location:529666
    Blast Score: 524
    DUF3740; Sulfatase protein
    cl19157
    Location:364389
    Blast Score: 112
    Sulfatase; Sulfatase
  6. XM_005260459.1XP_005260516.1  

    Conserved Domains (3) summary
    COG3119
    Location:43475
    Blast Score: 338
    AslA; Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]
    pfam00884
    Location:44375
    Blast Score: 352
    Sulfatase; Sulfatase
    cl19157
    Location:364389
    Blast Score: 112
    Sulfatase; Sulfatase

Alternate HuRef

Genomic

  1. AC_000152.1 

    Range
    43027474..43156926
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018931.2 

    Range
    46189453..46318659
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)