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    CPM carboxypeptidase M [ Homo sapiens (human) ]

    Gene ID: 1368, updated on 24-Aug-2015
    Official Symbol
    CPMprovided by HGNC
    Official Full Name
    carboxypeptidase Mprovided by HGNC
    Primary source
    HGNC:HGNC:2311
    See related
    Ensembl:ENSG00000135678; HPRD:00273; MIM:114860; Vega:OTTHUMG00000169300
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    The protein encoded by this gene is a membrane-bound arginine/lysine carboxypeptidase. Its expression is associated with monocyte to macrophage differentiation. This encoded protein contains hydrophobic regions at the amino and carboxy termini and has 6 potential asparagine-linked glycosylation sites. The active site residues of carboxypeptidases A and B are conserved in this protein. Three alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    12q14.3
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 12 NC_000012.12 (68851175..68963240, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (69244955..69357020, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene SUZ RNA binding domain containing 1 pseudogene Neighboring gene MDM2 proto-oncogene, E3 ubiquitin protein ligase Neighboring gene RNA, U7 small nuclear 4 pseudogene Neighboring gene PRELI domain containing 2 pseudogene Neighboring gene uncharacterized LOC105369821 Neighboring gene cleavage and polyadenylation specific factor 6, 68kDa Neighboring gene microRNA 1279

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    A genome-wide association study identifies susceptibility loci of silica related pneumoconiosis in Han Chinese.
    NHGRI GWA Catalog
    Genome-wide association-, replication-, and neuroimaging study implicates HOMER1 in the etiology of major depression.
    NHGRI GWA Catalog

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat Microarray analysis indicates HIV-1 Tat-induced upregulation of carboxypeptidase M (CPM) in primary human brain microvascular endothelial cells PubMed

    Go to the HIV-1, Human Interaction Database

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    carboxypeptidase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    metallocarboxypeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    anatomical structure morphogenesis TAS
    Traceable Author Statement
    more info
    PubMed 
    proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    anchored component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    carboxypeptidase M
    Names
    renal carboxypeptidase
    urinary carboxypeptidase B
    NP_001005502.1
    NP_001865.1
    NP_938079.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001005502.2NP_001005502.1  carboxypeptidase M precursor

      See identical proteins and their annotated locations for NP_001005502.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variants 1 and 2. All three variants encode the same protein.
      Source sequence(s)
      AC025423, AF368463, BC016943, BC022276, BQ431065, DA831499, DA833423, DB006895
      Consensus CDS
      CCDS8987.1
      UniProtKB/Swiss-Prot
      P14384
      Related
      ENSP00000339157, ENST00000338356
      Conserved Domains (2) summary
      cd03866
      Location:18310
      M14_CPM; Peptidase M14 carboxypeptidase subfamily N/E-like; Carboxypeptidase M subgroup
      cd11308
      Location:314394
      Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain
    2. NM_001874.4NP_001865.1  carboxypeptidase M precursor

      See identical proteins and their annotated locations for NP_001865.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR compared to variants 2 and 3. All three variants encode the same protein.
      Source sequence(s)
      AC025423, AF368463, BC016943, BC022276, BQ431065, DA831499, DA833423, J04970
      Consensus CDS
      CCDS8987.1
      UniProtKB/Swiss-Prot
      P14384
      Conserved Domains (2) summary
      cd03866
      Location:18310
      M14_CPM; Peptidase M14 carboxypeptidase subfamily N/E-like; Carboxypeptidase M subgroup
      cd11308
      Location:314394
      Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain
    3. NM_198320.3NP_938079.1  carboxypeptidase M precursor

      See identical proteins and their annotated locations for NP_938079.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variants 1 and 3. All three variants encode the same protein.
      Source sequence(s)
      AC025423, AF368463, BC016943, BC022276, BQ431065, DA205368, DA831499, DA833423, J04970
      Consensus CDS
      CCDS8987.1
      UniProtKB/Swiss-Prot
      P14384
      Related
      ENSP00000448517, OTTHUMP00000240713, ENST00000551568, OTTHUMT00000403355
      Conserved Domains (2) summary
      cd03866
      Location:18310
      M14_CPM; Peptidase M14 carboxypeptidase subfamily N/E-like; Carboxypeptidase M subgroup
      cd11308
      Location:314394
      Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p2 Primary Assembly

      Range
      68851175..68963240
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005268653.2XP_005268710.1  

      Conserved Domains (2) summary
      cd11308
      Location:193273
      Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain
      cl11393
      Location:1189
      Peptidase_M14_like; M14 family of metallocarboxypeptidases and related proteins
    2. XM_011537936.1XP_011536238.1  

      Conserved Domains (2) summary
      cd11308
      Location:125205
      Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain
      cl11393
      Location:17121
      Peptidase_M14_like; M14 family of metallocarboxypeptidases and related proteins

    Alternate CHM1_1.1

    Genomic

    1. NC_018923.2 Alternate CHM1_1.1

      Range
      69213548..69325636
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)