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    Myh10 myosin, heavy polypeptide 10, non-muscle [ Mus musculus (house mouse) ]

    Gene ID: 77579, updated on 26-Jun-2016
    Official Symbol
    Myh10provided by MGI
    Official Full Name
    myosin, heavy polypeptide 10, non-muscleprovided by MGI
    Primary source
    MGI:MGI:1930780
    See related
    Ensembl:ENSMUSG00000020900 Vega:OTTMUSG00000005955
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fltn; Myhn2; SMemb; Myhn-2; NMHC-B; NMMHC-B; NMHCII-B; NMHC II-B; NMMHC-IIB; mKIAA3005; NMMHC II-b; 5730504C04Rik; 9330167F11Rik
    Orthologs
    Location:
    11 B3; 11 41.95 cM
    Exon count:
    43
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (68691915..68816625)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (68505417..68630126)

    Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108167906 Neighboring gene coiled-coil domain containing 42 Neighboring gene nudE neurodevelopment protein 1 like 1 Neighboring gene ring finger protein 222

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (9)  1 citation
    • Chemically induced (ENU) (1) 
    • Endonuclease-mediated (1) 
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC115764

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ADP binding ISO
    Inferred from Sequence Orthology
    more info
     
    ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    actin binding IEA
    Inferred from Electronic Annotation
    more info
     
    actin filament binding ISO
    Inferred from Sequence Orthology
    more info
     
    actin-dependent ATPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
     
    microfilament motor activity ISO
    Inferred from Sequence Orthology
    more info
     
    motor activity IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    actin cytoskeleton organization IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    actin filament-based movement ISO
    Inferred from Sequence Orthology
    more info
     
    actomyosin structure organization ISO
    Inferred from Sequence Orthology
    more info
     
    adult heart development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    aorta development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    axonogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    brain development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cardiac myofibril assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cardiac septum development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cerebellar Purkinje cell layer development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    coronary vasculature development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    exocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    fourth ventricle development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    heart development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    in utero embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    lateral ventricle development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mitotic cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mitotic cytokinesis ISO
    Inferred from Sequence Orthology
    more info
     
    myofibril assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neuromuscular process controlling balance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neuron migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neuron projection development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    nuclear migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    plasma membrane repair IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of cell shape IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    retina development in camera-type eye IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    substrate-dependent cell migration, cell extension IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    third ventricle development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ventricular cardiac muscle cell development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    actomyosin ISO
    Inferred from Sequence Orthology
    more info
     
    axon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    brush border IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell cortex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell cortex ISO
    Inferred from Sequence Orthology
    more info
     
    cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    cleavage furrow ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    dendritic spine IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    growth cone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    midbody ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    myosin II complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    myosin II complex ISO
    Inferred from Sequence Orthology
    more info
     
    myosin II filament ISO
    Inferred from Sequence Orthology
    more info
     
    myosin complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with neuromuscular junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuron projection IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuronal cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with spindle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    stress fiber IDA
    Inferred from Direct Assay
    more info
    PubMed 
    stress fiber IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    stress fiber ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    myosin-10
    Names
    cellular myosin heavy chain, type B
    flectin
    myosin IIB
    myosin heavy chain 10, non-muscle
    myosin heavy chain, non-muscle IIb
    myosin heavy chain, nonmuscular, type B
    non-muscle myosin heavy chain B
    non-muscle myosin heavy chain IIb
    nonmuscle myosin heavy chain II-B

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_175260.2NP_780469.1  myosin-10

      See identical proteins and their annotated locations for NP_780469.1

      Status: VALIDATED

      Source sequence(s)
      AK029236, AK147567, CJ100063
      Consensus CDS
      CCDS24869.1
      UniProtKB/Swiss-Prot
      Q61879
      UniProtKB/TrEMBL
      Q3UH59
      Related
      ENSMUSP00000099671, OTTMUSP00000006152, ENSMUST00000102611, OTTMUST00000013276
      Conserved Domains (8) summary
      pfam01576
      Location:10731930
      Myosin_tail_1; Myosin tail
      smart00242
      Location:80783
      MYSc; Myosin. Large ATPases
      pfam02736
      Location:3375
      Myosin_N; Myosin N-terminal SH3-like domain
      cl19818
      Location:16451696
      DUF106; Integral membrane protein DUF106
      TIGR03495
      Location:17691867
      phage_LysB; phage lysis regulatory protein, LysB family
      cl19511
      Location:11111222
      DUF2317; Uncharacterized protein conserved in bacteria (DUF2317)
      cl22438
      Location:15261666
      TMF_TATA_bd; TATA element modulatory factor 1 TATA binding
      cd14920
      Location:99771
      MYSc_Myh10; class II myosin heavy chain 10, motor domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

      Range
      68691915..68816625
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006534489.2XP_006534552.1  

      UniProtKB/TrEMBL
      Q5SV64
      Related
      ENSMUSP00000018887, OTTMUSP00000006153, ENSMUST00000018887, OTTMUST00000013277
      Conserved Domains (9) summary
      pfam01576
      Location:11041961
      Myosin_tail_1; Myosin tail
      smart00242
      Location:80814
      MYSc; Myosin. Large ATPases
      pfam02736
      Location:3375
      Myosin_N; Myosin N-terminal SH3-like domain
      cl19818
      Location:16761727
      DUF106; Integral membrane protein DUF106
      TIGR03495
      Location:18001898
      phage_LysB; phage lysis regulatory protein, LysB family
      cl19511
      Location:11421253
      DUF2317; Uncharacterized protein conserved in bacteria (DUF2317)
      cl21509
      Location:12241371
      ApoLp-III_like; Apolipophorin-III and similar insect proteins
      cl22438
      Location:15571697
      TMF_TATA_bd; TATA element modulatory factor 1 TATA binding
      cd14920
      Location:99802
      MYSc_Myh10; class II myosin heavy chain 10, motor domain
    2. XM_017314835.1XP_017170324.1  

    3. XM_017314834.1XP_017170323.1