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    Sod2 superoxide dismutase 2, mitochondrial [ Mus musculus (house mouse) ]

    Gene ID: 20656, updated on 17-Sep-2016
    Official Symbol
    Sod2provided by MGI
    Official Full Name
    superoxide dismutase 2, mitochondrialprovided by MGI
    Primary source
    MGI:MGI:98352
    See related
    Ensembl:ENSMUSG00000006818
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MnSOD; Sod-2
    Orthologs
    Location:
    17 A1; 17 8.75 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 17 NC_000083.6 (13007839..13018119)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (13200705..13210985)

    Chromosome 17 - NC_000083.6Genomic Context describing neighboring genes Neighboring gene 28S ribosomal protein S18c, mitochondrial pseudogene Neighboring gene Wilms tumour 1-associating protein Neighboring gene predicted gene, 36117 Neighboring gene G protein-coupled receptor 31, D17Leh66b region

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Cellular responses to stress, organism-specific biosystem (from REACTOME)
      Cellular responses to stress, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Detoxification of Reactive Oxygen Species, organism-specific biosystem (from REACTOME)
      Detoxification of Reactive Oxygen Species, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • FoxO signaling pathway, organism-specific biosystem (from KEGG)
      FoxO signaling pathway, organism-specific biosystemThe forkhead box O (FOXO) family of transcription factors regulates the expression of genes in cellular physiological events including apoptosis, cell-cycle control, glucose metabolism, oxidative str...
    • Huntington's disease, organism-specific biosystem (from KEGG)
      Huntington's disease, organism-specific biosystemHuntington disease (HD) is an autosomal-dominant neurodegenerative disorder that primarily affects medium spiny striatal neurons (MSN). The symptoms are choreiform, involuntary movements, personality...
    • Huntington's disease, conserved biosystem (from KEGG)
      Huntington's disease, conserved biosystemHuntington disease (HD) is an autosomal-dominant neurodegenerative disorder that primarily affects medium spiny striatal neurons (MSN). The symptoms are choreiform, involuntary movements, personality...
    • Longevity regulating pathway, organism-specific biosystem (from KEGG)
      Longevity regulating pathway, organism-specific biosystemRegulation of longevity depends on genetic and environmental factors. Caloric restriction (CR), that is limiting food intake, is recognized in mammals as the best characterized and most reproducible ...
    • Longevity regulating pathway - multiple species, organism-specific biosystem (from KEGG)
      Longevity regulating pathway - multiple species, organism-specific biosystemAging is a complex process of accumulation of molecular, cellular, and organ damage, leading to loss of function and increased vulnerability to disease and death. Despite the complexity of aging, rec...
    • Longevity regulating pathway - multiple species, conserved biosystem (from KEGG)
      Longevity regulating pathway - multiple species, conserved biosystemAging is a complex process of accumulation of molecular, cellular, and organ damage, leading to loss of function and increased vulnerability to disease and death. Despite the complexity of aging, rec...
    • One carbon metabolism and related pathways, organism-specific biosystem (from WikiPathways)
      One carbon metabolism and related pathways, organism-specific biosystemThis pathway shows the carbon metabolism over grey and related pathways around it.
    • Oxidative Stress, organism-specific biosystem (from WikiPathways)
      Oxidative Stress, organism-specific biosystem
      Oxidative Stress
    • Peroxisome, organism-specific biosystem (from KEGG)
      Peroxisome, organism-specific biosystemPeroxisomes are essential organelles that play a key role in redox signalling and lipid homeostasis. They contribute to many crucial metabolic processes such as fatty acid oxidation, biosynthesis of ...
    • Peroxisome, conserved biosystem (from KEGG)
      Peroxisome, conserved biosystemPeroxisomes are essential organelles that play a key role in redox signalling and lipid homeostasis. They contribute to many crucial metabolic processes such as fatty acid oxidation, biosynthesis of ...
    • superoxide radicals degradation, organism-specific biosystem (from BIOCYC)
      superoxide radicals degradation, organism-specific biosystemPathway summary from MetaCyc. In humans, mutations in the gene encoding catalase are associated with an inborn error of metabolism called acatalasia
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC6144

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    manganese ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    oxidoreductase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    oxygen binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    superoxide dismutase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    superoxide dismutase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    superoxide dismutase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    age-dependent response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    age-dependent response to reactive oxygen species ISO
    Inferred from Sequence Orthology
    more info
     
    apoptotic mitochondrial changes IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    detection of oxygen IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    erythrophore differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    glutathione metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    heart development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    hemopoiesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    hydrogen peroxide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    hydrogen peroxide metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    intrinsic apoptotic signaling pathway in response to DNA damage IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    intrinsic apoptotic signaling pathway in response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    iron ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    liver development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mitochondrion organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of fat cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of fibroblast proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    neuron development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    oxidation-reduction process IEA
    Inferred from Electronic Annotation
    more info
     
    oxygen homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of nitric oxide biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    post-embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein homooligomerization ISO
    Inferred from Sequence Orthology
    more info
     
    protein homotetramerization ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of blood pressure IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of catalytic activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of mitochondrial membrane potential IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    release of cytochrome c from mitochondria IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    removal of superoxide radicals IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    removal of superoxide radicals ISO
    Inferred from Sequence Orthology
    more info
     
    respiratory electron transport chain IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to axon injury IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to drug ISO
    Inferred from Sequence Orthology
    more info
     
    response to gamma radiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    response to hydrogen peroxide IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to hyperoxia IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to nutrient levels ISO
    Inferred from Sequence Orthology
    more info
     
    response to oxidative stress IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to reactive oxygen species IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to superoxide IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to superoxide ISO
    Inferred from Sequence Orthology
    more info
     
    NOT sensory perception of sound IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    superoxide anion generation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    superoxide metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    superoxide metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    vasodilation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    vasodilation by acetylcholine involved in regulation of systemic arterial blood pressure IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrial nucleoid ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    myelin sheath IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    superoxide dismutase [Mn], mitochondrial
    Names
    manganese SOD
    manganese superoxide dismutase
    NP_038699.2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013671.3NP_038699.2  superoxide dismutase [Mn], mitochondrial precursor

      See identical proteins and their annotated locations for NP_038699.2

      Status: VALIDATED

      Source sequence(s)
      AK135435, AL589878, BY137511
      Consensus CDS
      CCDS28399.1
      UniProtKB/Swiss-Prot
      P09671
      UniProtKB/TrEMBL
      Q4FJX9
      Related
      ENSMUSP00000007012, ENSMUST00000007012
      Conserved Domains (3) summary
      COG0605
      Location:25222
      SodA; Superoxide dismutase [Inorganic ion transport and metabolism]
      pfam00081
      Location:25106
      Sod_Fe_N; Iron/manganese superoxide dismutases, alpha-hairpin domain
      pfam02777
      Location:113216
      Sod_Fe_C; Iron/manganese superoxide dismutases, C-terminal domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000083.6 Reference GRCm38.p4 C57BL/6J

      Range
      13007839..13018119
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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