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    Nedd9 neural precursor cell expressed, developmentally down-regulated gene 9 [ Mus musculus (house mouse) ]

    Gene ID: 18003, updated on 10-Sep-2016
    Official Symbol
    Nedd9provided by MGI
    Official Full Name
    neural precursor cell expressed, developmentally down-regulated gene 9provided by MGI
    Primary source
    MGI:MGI:97302
    See related
    Ensembl:ENSMUSG00000021365
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CasL; HEF1; MEF1; p105; Cas-L; Nedd-9
    Orthologs
    Location:
    13; 13 A3.3-A4
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 13 NC_000079.6 (41309916..41487360, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (41405285..41582689, complement)

    Chromosome 13 - NC_000079.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 32063 Neighboring gene small integral membrane protein 13 Neighboring gene predicted gene, 32448 Neighboring gene predicted gene, 32401 Neighboring gene predicted gene, 32184 Neighboring gene transmembrane protein 170B

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • E230025G09Rik

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    cell division IEA
    Inferred from Electronic Annotation
    more info
     
    mitotic nuclear division IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of growth IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    spindle pole IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    enhancer of filamentation 1
    Names
    CRK-associated substrate-related protein
    Crk-associated substrate lymphocyte-specific protein

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001111324.2NP_001104794.1  enhancer of filamentation 1 isoform 1

      See identical proteins and their annotated locations for NP_001104794.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes isoform 1.
      Source sequence(s)
      AK046357, AK083374, AV367231, BB842569, BY001380
      Consensus CDS
      CCDS49247.1
      UniProtKB/Swiss-Prot
      O35177
      Related
      ENSMUSP00000021794, ENSMUST00000021794
      Conserved Domains (3) summary
      cd11550
      Location:400560
      Serine_rich_NEDD9; Serine rich Four helix bundle domain of CAS (Crk-Associated Substrate) scaffolding protein, Neural precursor cell Expressed, Developmentally Down-regulated 9; a protein interaction module
      cd12002
      Location:763
      SH3_NEDD9; Src homology 3 domain of CAS (Crk-Associated Substrate) scaffolding protein family member, Neural precursor cell Expressed, Developmentally Down-regulated 9
      pfam12026
      Location:620827
      DUF3513; Domain of unknown function (DUF3513)
    2. NM_017464.5NP_059492.3  enhancer of filamentation 1 isoform 2

      See identical proteins and their annotated locations for NP_059492.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate 5'-most exon and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is the same length as isoform 1.
      Source sequence(s)
      AA198880, AA762918, AK033729, AK054179, AV367231
      Consensus CDS
      CCDS36640.2
      UniProtKB/Swiss-Prot
      O35177
      UniProtKB/TrEMBL
      A0A0R4J212
      Related
      ENSMUSP00000125773, ENSMUST00000163623
      Conserved Domains (3) summary
      cd11550
      Location:400560
      Serine_rich_NEDD9; Serine rich Four helix bundle domain of CAS (Crk-Associated Substrate) scaffolding protein, Neural precursor cell Expressed, Developmentally Down-regulated 9; a protein interaction module
      cd11570
      Location:703830
      FAT-like_NEDD9_C; C-terminal FAT-like Four helix bundle domain, also called DUF3513, of CAS (Crk-Associated Substrate) scaffolding protein, Neural precursor cell Expressed, Developmentally Down-regulated 9; a protein interaction module
      cd12002
      Location:763
      SH3_NEDD9; Src homology 3 domain of CAS (Crk-Associated Substrate) scaffolding protein family member, Neural precursor cell Expressed, Developmentally Down-regulated 9

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000079.6 Reference GRCm38.p4 C57BL/6J

      Range
      41309916..41487360 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006516874.3XP_006516937.1  

      Conserved Domains (3) summary
      cd11550
      Location:401561
      Serine_rich_NEDD9; Serine rich Four helix bundle domain of CAS (Crk-Associated Substrate) scaffolding protein, Neural precursor cell Expressed, Developmentally Down-regulated 9; a protein interaction module
      cd12002
      Location:864
      SH3_NEDD9; Src homology 3 domain of CAS (Crk-Associated Substrate) scaffolding protein family member, Neural precursor cell Expressed, Developmentally Down-regulated 9
      pfam12026
      Location:621828
      DUF3513; Domain of unknown function (DUF3513)
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