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    Crp C-reactive protein, pentraxin-related [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25419, updated on 20-Aug-2016
    Official Symbol
    Crpprovided by RGD
    Official Full Name
    C-reactive protein, pentraxin-relatedprovided by RGD
    Primary source
    RGD:2411
    See related
    Ensembl:ENSRNOG00000000053
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Aa1249; Ac1262; Ab1-341; Ab2-196; Ac1-114; Ac2-069; Ba2-693
    Summary
    glycoprotein of the acute phase response [RGD, Feb 2006]
    Orthologs
    Location:
    13q24
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (91080448..91081358)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 13 NC_005112.3 (95599418..95600328)

    Chromosome 13 - NC_005112.4Genomic Context describing neighboring genes Neighboring gene Fc receptor-like 6 Neighboring gene dual specificity phosphatase 23 Neighboring gene Fc fragment of IgG, low affinity IIa, receptor Neighboring gene transfer RNA aspartic acid (anticodon GUC) Neighboring gene transfer RNA leucine (anticodon CAG)

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    cholesterol binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    complement component C1q binding ISO
    Inferred from Sequence Orthology
    more info
     
    low-density lipoprotein particle binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    low-density lipoprotein particle binding ISO
    Inferred from Sequence Orthology
    more info
     
    low-density lipoprotein particle receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NOT virion binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acute-phase response IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    aging IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to calcium ion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to interleukin-6 IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to nitric oxide IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    complement activation, classical pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of lipid storage ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of macrophage derived foam cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of superoxide anion generation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of vasodilation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of dendrite development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of nitric oxide biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of superoxide anion generation ISO
    Inferred from Sequence Orthology
    more info
     
    protein polymerization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of interleukin-8 secretion ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of interleukin-8 secretion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of low-density lipoprotein particle clearance IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to estradiol IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to ethanol IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to hypoxia IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to lead ion IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to radiation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to testosterone IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    wound healing IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    filopodium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    growth cone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    C-reactive protein
    Names
    C-reactive protein member of the pentraxin family
    C-reactive protein, member of the pentraxin family
    C-reactive protein, petaxin related

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017096.3NP_058792.1  C-reactive protein precursor

      See identical proteins and their annotated locations for NP_058792.1

      Status: PROVISIONAL

      Source sequence(s)
      M83176
      UniProtKB/Swiss-Prot
      P48199
      UniProtKB/TrEMBL
      H6X2W5
      Related
      ENSRNOP00000000058, ENSRNOT00000000058
      Conserved Domains (1) summary
      smart00159
      Location:20223
      PTX; Pentraxin / C-reactive protein / pentaxin family

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005112.4 Reference Rnor_6.0 Primary Assembly

      Range
      91080448..91081358
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Rn_Celera

    Genomic

    1. AC_000081.1 Alternate Rn_Celera

      Range
      84770843..84771753
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)