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CDK12 cyclin-dependent kinase 12 [ Homo sapiens (human) ]

Gene ID: 51755, updated on 11-Sep-2014
Official Symbol
CDK12provided by HGNC
Official Full Name
cyclin-dependent kinase 12provided by HGNC
Primary source
HGNC:HGNC:24224
Locus tag
RP11-390P24.1
See related
Ensembl:ENSG00000167258; HPRD:10849; MIM:615514; Vega:OTTHUMG00000133214
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CRK7; CRKR; CRKRS
See CDK12 in Epigenomics, MapViewer
Location:
17q12
Exon count:
26
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 17 NC_000017.11 (39461486..39567559)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (37617739..37721398)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene F-box and leucine-rich repeat protein 20 Neighboring gene mediator complex subunit 1 Neighboring gene neuronal differentiation 2 Neighboring gene protein phosphatase 1, regulatory (inhibitor) subunit 1B

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • KIAA0904

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
RNA polymerase II carboxy-terminal domain kinase activity IMP
Inferred from Mutant Phenotype
more info
 
cyclin binding IPI
Inferred from Physical Interaction
more info
 
cyclin-dependent protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
RNA splicing ISS
Inferred from Sequence or Structural Similarity
more info
 
mRNA processing IEA
Inferred from Electronic Annotation
more info
 
phosphorylation of RNA polymerase II C-terminal domain IMP
Inferred from Mutant Phenotype
more info
 
protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of MAP kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cell cycle IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cyclin K-CDK12 complex IPI
Inferred from Physical Interaction
more info
 
nuclear cyclin-dependent protein kinase holoenzyme complex ISS
Inferred from Sequence or Structural Similarity
more info
 
nuclear speck IDA
Inferred from Direct Assay
more info
PubMed 
nucleolus IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
 
Preferred Names
cyclin-dependent kinase 12
Names
cyclin-dependent kinase 12
CDC2-related protein kinase 7
cell division protein kinase 12
Cdc2-related kinase, arginine/serine-rich
cell division cycle 2-related protein kinase 7
NP_055898.1
NP_057591.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015083.2NP_055898.1  cyclin-dependent kinase 12 isoform 2

    See proteins identical to NP_055898.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
    Source sequence(s)
    AC009283, AK302645, BC150265, BE003756, BM557102
    Consensus CDS
    CCDS45666.1
    UniProtKB/Swiss-Prot
    Q9NYV4
    Conserved Domains (2) summary
    cd07864
    Location:7191020
    Blast Score: 1740
    STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12
    smart00220
    Location:7271020
    Blast Score: 755
    S_TKc; Serine/Threonine protein kinases, catalytic domain
  2. NM_016507.3NP_057591.2  cyclin-dependent kinase 12 isoform 1

    See proteins identical to NP_057591.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform.
    Source sequence(s)
    AC009283, AF227198, AK302645, BC150265, BE003756, BM557102
    Consensus CDS
    CCDS11337.1
    UniProtKB/Swiss-Prot
    Q9NYV4
    Related
    ENSP00000398880, OTTHUMP00000164282, ENST00000447079, OTTHUMT00000256941
    Conserved Domains (2) summary
    cd07864
    Location:7191020
    Blast Score: 1740
    STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12
    smart00220
    Location:7271020
    Blast Score: 755
    S_TKc; Serine/Threonine protein kinases, catalytic domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000017.11 

    Range
    39461486..39567559
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005257456.1XP_005257513.1  

    Conserved Domains (2) summary
    cd07864
    Location:7181019
    Blast Score: 1740
    STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12
    smart00220
    Location:7261019
    Blast Score: 755
    S_TKc; Serine/Threonine protein kinases, catalytic domain
  2. XM_005257458.2XP_005257515.1  

    Related
    ENSP00000464641, OTTHUMP00000260413, ENST00000584632, OTTHUMT00000444156
    Conserved Domains (2) summary
    cd07864
    Location:7191020
    Blast Score: 1728
    STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12
    smart00220
    Location:7271020
    Blast Score: 755
    S_TKc; Serine/Threonine protein kinases, catalytic domain

RNA

  1. XR_429898.1 RNA Sequence

  2. XR_429896.1 RNA Sequence

  3. XR_429897.1 RNA Sequence

  4. XR_429899.1 RNA Sequence

  5. XR_429900.1 RNA Sequence

  6. XR_429902.1 RNA Sequence

  7. XR_429904.1 RNA Sequence

  8. XR_429901.1 RNA Sequence

  9. XR_429903.1 RNA Sequence

Alternate HuRef

Genomic

  1. AC_000149.1 

    Range
    33411119..33484376
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018928.2 

    Range
    37853958..37926678
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)