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    PSCA prostate stem cell antigen [ Homo sapiens (human) ]

    Gene ID: 8000, updated on 14-Aug-2016
    Official Symbol
    PSCAprovided by HGNC
    Official Full Name
    prostate stem cell antigenprovided by HGNC
    Primary source
    HGNC:HGNC:9500
    See related
    Ensembl:ENSG00000167653 HPRD:03919; MIM:602470; Vega:OTTHUMG00000162077
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PRO232
    Summary
    This gene encodes a glycosylphosphatidylinositol-anchored cell membrane glycoprotein. In addition to being highly expressed in the prostate it is also expressed in the bladder, placenta, colon, kidney, and stomach. This gene is up-regulated in a large proportion of prostate cancers and is also detected in cancers of the bladder and pancreas. This gene includes a polymorphism that results in an upstream start codon in some individuals; this polymorphism is thought to be associated with a risk for certain gastric and bladder cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]
    Orthologs
    Location:
    8q24.2
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 8 NC_000008.11 (142670308..142682727)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (143751726..143764145)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101928087 Neighboring gene Jrk helix-turn-helix protein Neighboring gene uncharacterized LOC100288181 Neighboring gene lymphocyte antigen 6 complex, locus K Neighboring gene thioesterase superfamily member 6

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    A genome-wide association study identifies two susceptibility loci for duodenal ulcer in the Japanese population.
    NHGRI GWA Catalog
    A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci.
    NHGRI GWA Catalog
    Genetic variation in the prostate stem cell antigen gene PSCA confers susceptibility to urinary bladder cancer.
    NHGRI GWA Catalog
    Genome-wide association study identifies multiple loci associated with bladder cancer risk.
    NHGRI GWA Catalog
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    anchored component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_011722.3 RefSeqGene

      Range
      15149..17420
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_005672.4NP_005663.2  prostate stem cell antigen preproprotein

      See identical proteins and their annotated locations for NP_005663.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript but encodes the functional protein.
      Source sequence(s)
      AI685668, BC048808, CB993163
      Consensus CDS
      CCDS47925.2
      UniProtKB/TrEMBL
      D3DWI6
      Related
      ENSP00000301258, OTTHUMP00000221185, ENST00000301258, OTTHUMT00000367112
      Conserved Domains (1) summary
      cd00117
      Location:1286
      LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...

    RNA

    1. NR_033343.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in its 5'-most exon, compared to variant 1. This variant is represented as non-coding because it lacks an in-frame coding region, compared to variant 1.
      Source sequence(s)
      AI685668, BC048808, BI758811, BU157227

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p7 Primary Assembly

      Range
      142670308..142682727
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018919.2 Alternate CHM1_1.1

      Range
      143791995..143804414
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)