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BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 [ Homo sapiens (human) ]

Gene ID: 664, updated on 26-Aug-2014
Official Symbol
BNIP3provided by HGNC
Official Full Name
BCL2/adenovirus E1B 19kDa interacting protein 3provided by HGNC
Primary source
HGNC:1084
See related
HPRD:04482; MIM:603293
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NIP3
Summary
This gene is a member of the BCL2/adenovirus E1B 19 kd-interacting protein (BNIP) family. It interacts with the E1B 19 kDa protein, which protects cells from virally-induced cell death. The encoded protein also interacts with E1B 19 kDa-like sequences of BCL2, another apoptotic protector. This protein contains a BH3 domain and a transmembrane domain, which have been associated with pro-apoptotic function. The dimeric mitochondrial protein encoded by this gene is known to induce apoptosis, even in the presence of BCL2. [provided by RefSeq, Mar 2011]
See BNIP3 in Epigenomics, MapViewer
Location:
10q26.3
Exon count:
6
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 10 NC_000010.11 (131967700..131981931, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (133781204..133795435, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene zonadhesin-like Neighboring gene 60S ribosomal protein L19-like Neighboring gene protein phosphatase 2, regulatory subunit B, delta Neighboring gene Janus kinase and microtubule interacting protein 3 Neighboring gene dihydropyrimidinase-like 4

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Vpr vpr Treatment of human primary astrocytes with HIV-1 Vpr downregulates expression of eleven genes, BNIP3, CYGB, DUOX2, DUSP1, FOXM1, GAPDH, HPRT1, MT3, MTL5, PTGS2, and SCARA3 PubMed
vpr Overexpression of BNIP3 is induced by HIV-1 Vpr in the transfected 293T cells PubMed

Go to the HIV-1, Human Protein Interaction Database

  • Apoptosis Modulation and Signaling, organism-specific biosystem (from WikiPathways)
    Apoptosis Modulation and Signaling, organism-specific biosystemApoptosis, or cell death program, can be activated by various mechanisms within the extrinsic and the intrinsic pathway. While activation of cell death receptors leads to the engagement of the extrin...
  • FoxO signaling pathway, organism-specific biosystem (from KEGG)
    FoxO signaling pathway, organism-specific biosystemThe forkhead box O (FOXO) family of transcription factors regulates the expression of genes in cellular physiological events including apoptosis, cell-cycle control, glucose metabolism, oxidative str...
  • HIF-1-alpha transcription factor network, organism-specific biosystem (from Pathway Interaction Database)
    HIF-1-alpha transcription factor network, organism-specific biosystem
    HIF-1-alpha transcription factor network
  • Legionellosis, organism-specific biosystem (from KEGG)
    Legionellosis, organism-specific biosystemLegionellosis is a potentially fatal infectious disease caused by the bacterium Legionella pneumophila and other legionella species. Two distinct clinical and epidemiological syndromes are associated...
  • Legionellosis, conserved biosystem (from KEGG)
    Legionellosis, conserved biosystemLegionellosis is a potentially fatal infectious disease caused by the bacterium Legionella pneumophila and other legionella species. Two distinct clinical and epidemiological syndromes are associated...
  • mTOR signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
    mTOR signaling pathway, organism-specific biosystem
    mTOR signaling pathway
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTPase binding IPI
Inferred from Physical Interaction
more info
 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
apoptotic process IPI
Inferred from Physical Interaction
more info
PubMed 
autophagic cell death IEA
Inferred from Electronic Annotation
more info
 
brown fat cell differentiation IEA
Inferred from Electronic Annotation
more info
 
cell death ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to cobalt ion IMP
Inferred from Mutant Phenotype
more info
 
cellular response to hydrogen peroxide IEA
Inferred from Electronic Annotation
more info
 
cellular response to hypoxia IMP
Inferred from Mutant Phenotype
more info
 
cellular response to mechanical stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
defense response to virus IDA
Inferred from Direct Assay
more info
PubMed 
granzyme-mediated apoptotic signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
intrinsic apoptotic signaling pathway in response to hypoxia IMP
Inferred from Mutant Phenotype
more info
 
mitochondrial fragmentation involved in apoptotic process IDA
Inferred from Direct Assay
more info
 
mitochondrial outer membrane permeabilization IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrial protein catabolic process IMP
Inferred from Mutant Phenotype
more info
 
negative regulation of apoptotic process TAS
Traceable Author Statement
more info
PubMed 
negative regulation of membrane potential IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of mitochondrial fusion IDA
Inferred from Direct Assay
more info
 
neuron apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of autophagy TAS
Traceable Author Statement
more info
PubMed 
positive regulation of mitochondrial fission IDA
Inferred from Direct Assay
more info
 
positive regulation of programmed cell death IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein complex disassembly IDA
Inferred from Direct Assay
more info
 
positive regulation of release of cytochrome c from mitochondria IDA
Inferred from Direct Assay
more info
 
reactive oxygen species metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
regulation of mitochondrial membrane permeability IDA
Inferred from Direct Assay
more info
PubMed 
response to hyperoxia IEA
Inferred from Electronic Annotation
more info
 
response to hypoxia ISS
Inferred from Sequence or Structural Similarity
more info
 
viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
dendrite ISS
Inferred from Sequence or Structural Similarity
more info
 
endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
 
integral component of mitochondrial outer membrane IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrial membrane IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrial membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitochondrial outer membrane IDA
Inferred from Direct Assay
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion TAS
Traceable Author Statement
more info
PubMed 
nuclear envelope IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
Preferred Names
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3
Names
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004052.2NP_004043.2  BCL2/adenovirus E1B 19 kDa protein-interacting protein 3

    See proteins identical to NP_004043.2

    Status: REVIEWED

    Source sequence(s)
    AF002697
    Consensus CDS
    CCDS7663.1
    UniProtKB/Swiss-Prot
    Q12983
    Conserved Domains (1) summary
    pfam06553
    Location:1192
    Blast Score: 593
    BNIP3; BNIP3

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000010.11 

    Range
    131967700..131981931
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000142.1 

    Range
    127330366..127344602
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018921.2 

    Range
    134062287..134076530
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)