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    MAST2 microtubule associated serine/threonine kinase 2 [ Homo sapiens (human) ]

    Gene ID: 23139, updated on 7-Feb-2016
    Official Symbol
    MAST2provided by HGNC
    Official Full Name
    microtubule associated serine/threonine kinase 2provided by HGNC
    Primary source
    HGNC:HGNC:19035
    See related
    Ensembl:ENSG00000086015; HPRD:11294; MIM:612257; Vega:OTTHUMG00000008007
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MTSSK; MAST205
    Orthologs
    See MAST2 in Epigenomics, MapViewer
    Location:
    1p34.1
    Exon count:
    37
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 1 NC_000001.11 (45786992..46036124)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (46269269..46501796)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378693 Neighboring gene ribosomal protein L6 pseudogene 1 Neighboring gene uncharacterized LOC105378694 Neighboring gene translation machinery associated 16 homolog pseudogene 2 Neighboring gene phosphoinositide-3-kinase regulatory subunit 3 Neighboring gene uncharacterized LOC101929626 Neighboring gene uncharacterized LOC105378695 Neighboring gene tetraspanin 1

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • FLJ39200, KIAA0807

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    magnesium ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    phosphatase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    peptidyl-serine phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    protein phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of interleukin-12 biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    spermatid differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
     
    microtubule cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    microtubule-associated serine/threonine-protein kinase 2
    Names
    MAST2
    microtubule associated testis specific serine/threonine protein kinase
    NP_055927.2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001319245.1NP_001306174.1  microtubule-associated serine/threonine-protein kinase 2 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice junction in the 3' end compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is 1 aa shorter compared to isoform 1.
      Source sequence(s)
      AB047005, AL358075, AL603882, BC065499, BM675011
    2. NM_015112.2NP_055927.2  microtubule-associated serine/threonine-protein kinase 2 isoform 1

      See identical proteins and their annotated locations for NP_055927.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AB047005, AL540100, AL603882, BC065499, BM675011, CN297081
      Consensus CDS
      CCDS41326.1
      UniProtKB/Swiss-Prot
      Q6P0Q8
      Related
      ENSP00000354671, OTTHUMP00000009697, ENST00000361297, OTTHUMT00000021977
      Conserved Domains (4) summary
      pfam08926
      Location:201476
      DUF1908; Domain of unknown function (DUF1908)
      smart00220
      Location:512785
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd00992
      Location:11051186
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd05609
      Location:511790
      STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p2 Primary Assembly

      Range
      45786992..46036124
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011541065.1XP_011539367.1  

      Conserved Domains (4) summary
      pfam08926
      Location:127409
      DUF1908; Domain of unknown function (DUF1908)
      smart00220
      Location:445718
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd00992
      Location:10381119
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd05609
      Location:444723
      STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    2. XM_011541059.1XP_011539361.1  

      Conserved Domains (4) summary
      pfam08926
      Location:266548
      DUF1908; Domain of unknown function (DUF1908)
      smart00220
      Location:584857
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd00992
      Location:11771258
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd05609
      Location:583862
      STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    3. XM_011541061.1XP_011539363.1  

      Conserved Domains (4) summary
      pfam08926
      Location:266548
      DUF1908; Domain of unknown function (DUF1908)
      smart00220
      Location:584857
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd00992
      Location:11771258
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd05609
      Location:583862
      STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    4. XM_011541062.1XP_011539364.1  

      Conserved Domains (4) summary
      pfam08926
      Location:266541
      DUF1908; Domain of unknown function (DUF1908)
      smart00220
      Location:577850
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd00992
      Location:11701251
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd05609
      Location:576855
      STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    5. XM_005270652.3XP_005270709.1  

      Conserved Domains (4) summary
      pfam08926
      Location:201483
      DUF1908; Domain of unknown function (DUF1908)
      smart00220
      Location:519792
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd00992
      Location:11121193
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd05609
      Location:518797
      STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    6. XM_005270654.2XP_005270711.1  

      UniProtKB/Swiss-Prot
      Q6P0Q8
      Conserved Domains (4) summary
      pfam08926
      Location:201476
      DUF1908; Domain of unknown function (DUF1908)
      smart00220
      Location:512785
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd00992
      Location:11051186
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd05609
      Location:511790
      STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    7. XM_011541060.1XP_011539362.1  

      Conserved Domains (4) summary
      pfam08926
      Location:265547
      DUF1908; Domain of unknown function (DUF1908)
      smart00220
      Location:583856
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd00992
      Location:11761257
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd05609
      Location:582861
      STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    8. XM_006710475.2XP_006710538.1  

      Conserved Domains (4) summary
      pfam08926
      Location:200482
      DUF1908; Domain of unknown function (DUF1908)
      smart00220
      Location:518791
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd00992
      Location:11111192
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd05609
      Location:517796
      STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    9. XM_011541069.1XP_011539371.1  

      Conserved Domains (4) summary
      pfam08926
      Location:266548
      DUF1908; Domain of unknown function (DUF1908)
      smart00220
      Location:584857
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd00992
      Location:11771258
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd05609
      Location:583862
      STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    10. XM_011541064.1XP_011539366.1  

      Conserved Domains (4) summary
      pfam08926
      Location:213495
      DUF1908; Domain of unknown function (DUF1908)
      smart00220
      Location:531804
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd00992
      Location:11241205
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd05609
      Location:530809
      STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    11. XM_011541063.1XP_011539365.1  

      Conserved Domains (4) summary
      pfam08926
      Location:216498
      DUF1908; Domain of unknown function (DUF1908)
      smart00220
      Location:534807
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd00992
      Location:11271208
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd05609
      Location:533812
      STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    12. XM_005270656.3XP_005270713.1  

      Conserved Domains (4) summary
      pfam08926
      Location:107389
      DUF1908; Domain of unknown function (DUF1908)
      smart00220
      Location:425698
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd00992
      Location:10181099
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd05609
      Location:424703
      STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    13. XM_005270655.3XP_005270712.1  

      Conserved Domains (4) summary
      pfam08926
      Location:116398
      DUF1908; Domain of unknown function (DUF1908)
      smart00220
      Location:434707
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd00992
      Location:10271108
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd05609
      Location:433712
      STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    14. XM_006710477.2XP_006710540.1  

      Conserved Domains (4) summary
      pfam08926
      Location:51333
      DUF1908; Domain of unknown function (DUF1908)
      smart00220
      Location:369642
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd00992
      Location:9621043
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd05609
      Location:368647
      STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    15. XM_011541066.1XP_011539368.1  

      Conserved Domains (4) summary
      pfam08926
      Location:40322
      DUF1908; Domain of unknown function (DUF1908)
      smart00220
      Location:358631
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd00992
      Location:9511032
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd05609
      Location:357636
      STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    16. XM_011541068.1XP_011539370.1  

      Conserved Domains (4) summary
      pfam08926
      Location:39314
      DUF1908; Domain of unknown function (DUF1908)
      smart00220
      Location:350623
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd00992
      Location:9431024
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd05609
      Location:349628
      STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    17. XM_011541067.1XP_011539369.1  

      Conserved Domains (4) summary
      pfam08926
      Location:39321
      DUF1908; Domain of unknown function (DUF1908)
      smart00220
      Location:357630
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd00992
      Location:9501031
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd05609
      Location:356635
      STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase

    Alternate CHM1_1.1

    Genomic

    1. NC_018912.2 Alternate CHM1_1.1

      Range
      46386848..46618962
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)