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    PTPRD protein tyrosine phosphatase, receptor type D [ Homo sapiens (human) ]

    Gene ID: 5789, updated on 3-Jul-2016
    Official Symbol
    PTPRDprovided by HGNC
    Official Full Name
    protein tyrosine phosphatase, receptor type Dprovided by HGNC
    Primary source
    HGNC:HGNC:9668
    See related
    Ensembl:ENSG00000153707 HPRD:03358; MIM:601598; Vega:OTTHUMG00000021005
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HPTP; PTPD; HPTPD; HPTPDELTA; RPTPDELTA
    Summary
    The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular region, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this protein is composed of three Ig-like and eight fibronectin type III-like domains. Studies of the similar genes in chicken and fly suggest the role of this PTP is in promoting neurite growth, and regulating neurons axon guidance. Multiple alternatively spliced transcript variants of this gene have been reported. A related pseudogene has been identified on chromosome 5. [provided by RefSeq, Jan 2010]
    Orthologs
    Location:
    9p23-p24.3
    Exon count:
    49
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 9 NC_000009.12 (8314246..10612840, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (8314246..10612723, complement)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375971 Neighboring gene transmembrane protein 261 Neighboring gene ribosomal protein L18a pseudogene 11 Neighboring gene RNA, U7 small nuclear 185 pseudogene Neighboring gene PTPRD antisense RNA 1 Neighboring gene ribosomal protein S26 pseudogene 3 Neighboring gene RNA, 7SL, cytoplasmic 5, pseudogene Neighboring gene uncharacterized LOC105375972 Neighboring gene PTPRD antisense RNA 2 (head to head) Neighboring gene IMP3 pseudogene 1

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    A genome-wide association study and biological pathway analysis of epilepsy prognosis in a prospective cohort of newly treated epilepsy.
    NHGRI GWA Catalog
    A genome-wide association study identifies susceptibility variants for type 2 diabetes in Han Chinese.
    NHGRI GWA Catalog
    A genome-wide association study provides evidence for association of chromosome 8p23 (MYP10) and 10q21.1 (MYP15) with high myopia in the French Population.
    NHGRI GWA Catalog
    A genome-wide meta-analysis of association studies of Cloninger's Temperament Scales.
    NHGRI GWA Catalog
    Common genetic variation and susceptibility to partial epilepsies: a genome-wide association study.
    NHGRI GWA Catalog
    Conduct disorder and ADHD: evaluation of conduct problems as a categorical and quantitative trait in the international multicentre ADHD genetics study.
    NHGRI GWA Catalog
    Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects.
    NHGRI GWA Catalog
    Genome-wide association and meta-analysis in populations from Starr County, Texas, and Mexico City identify type 2 diabetes susceptibility loci and enrichment for expression quantitative trait loci in top signals.
    NHGRI GWA Catalog
    Genome-wide association studies identify CHRNA5/3 and HTR4 in the development of airflow obstruction.
    NHGRI GWA Catalog
    Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortiu
    NHGRI GWA Catalog
    Genome-wide association study identifies novel restless legs syndrome susceptibility loci on 2p14 and 16q12.1.
    NHGRI GWA Catalog
    Genome-wide association study in obsessive-compulsive disorder: results from the OCGAS.
    NHGRI GWA Catalog
    Genome-wide association study of co-occurring anxiety in major depression.
    NHGRI GWA Catalog
    Genome-Wide Association Study of Primary Dentition Pit-and-Fissure and Smooth Surface Caries.
    NHGRI GWA Catalog
    Genome-wide association study of the five-factor model of personality in young Korean women.
    NHGRI GWA Catalog
    Genome-wide meta-analyses identifies seven loci associated with platelet aggregation in response to agonists.
    NHGRI GWA Catalog
    Genome-wide meta-analysis identifies new susceptibility loci for migraine.
    NHGRI GWA Catalog
    Genome-wide SNP associations with rubella-specific cytokine responses in measles-mumps-rubella vaccine recipients.
    NHGRI GWA Catalog
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    NHGRI GWA Catalog
    Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
    NHGRI GWA Catalog
    PTPRD (protein tyrosine phosphatase receptor type delta) is associated with restless legs syndrome.
    NHGRI GWA Catalog
    • Neuronal System, organism-specific biosystem (from REACTOME)
      Neuronal System, organism-specific biosystemThe human brain contains at least 100 billion neurons, each with the ability to influence many other cells. Clearly, highly sophisticated and efficient mechanisms are needed to enable communication a...
    • SALM protein interactions at the synapse, organism-specific biosystem (from REACTOME)
      SALM protein interactions at the synapse, organism-specific biosystemRecruitment of receptors and ion channels to the postsynaptic membrane is the last step in synapse formation. Many of these proteins interact directly or indirectly with postsynaptic density-95 (PSD9...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC119750, MGC119751, MGC119752, MGC119753

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    cell adhesion molecule binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    receptor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    transmembrane receptor protein tyrosine phosphatase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    chemical synaptic transmission TAS
    Traceable Author Statement
    more info
     
    heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    neuron differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    peptidyl-tyrosine dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    phosphate-containing compound metabolic process NAS
    Non-traceable Author Statement
    more info
    PubMed 
    positive regulation of dendrite morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    presynaptic membrane assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein dephosphorylation TAS
    Traceable Author Statement
    more info
    PubMed 
    transmembrane receptor protein tyrosine phosphatase signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    Preferred Names
    receptor-type tyrosine-protein phosphatase delta
    Names
    R-PTP-delta
    protein tyrosine phosphatase, receptor type, D
    protein tyrosine phosphatase, receptor type, delta polypeptide
    NP_001035802.1
    NP_001164496.1
    NP_002830.1
    NP_569075.2
    NP_569076.2
    NP_569077.2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_033963.1 RefSeqGene

      Range
      5001..2303478
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001040712.2NP_001035802.1  receptor-type tyrosine-protein phosphatase delta isoform 5 precursor

      See identical proteins and their annotated locations for NP_001035802.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) has multiple differences in the coding region, compared to variant 1, resulting in an isoform (5) that is shorter than isoform 1. The 5' UTR of this variant is incomplete because no 5' complete transcripts representing this variant exist, and there are alternate splicing choices in the upstream region.
      Source sequence(s)
      AB208869, AL356584, AL445926, AL590397, BM680342, DR001889
      Consensus CDS
      CCDS55288.1
      UniProtKB/TrEMBL
      Q59H90
      Related
      ENSP00000380735, ENST00000397611
      Conserved Domains (9) summary
      cd05738
      Location:143223
      Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      cd05739
      Location:247315
      Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      smart00408
      Location:141211
      IGc2; Immunoglobulin C-2 Type
      smart00194
      Location:9461201
      PTPc; Protein tyrosine phosphatase, catalytic domain
      smart00410
      Location:239316
      IG_like; Immunoglobulin like
      cd00047
      Location:9721201
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:320409
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:24115
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:41115
      Ig; Immunoglobulin domain
    2. NM_001171025.1NP_001164496.1  receptor-type tyrosine-protein phosphatase delta isoform 6 precursor

      See identical proteins and their annotated locations for NP_001164496.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) has multiple differences in the coding region, compared to variant 1, resulting in an isoform (6) that is shorter than isoform 1. The 5' UTR of this variant is incomplete because no 5' complete transcripts representing this variant exist, and there are alternate splicing choices in the upstream region.
      Source sequence(s)
      AL445926, AL590397, BC106713, BM680342, DR001889
      Consensus CDS
      CCDS55289.1
      UniProtKB/Swiss-Prot
      P23468
      Related
      ENSP00000380731, OTTHUMP00000215419, ENST00000397606, OTTHUMT00000055398
      Conserved Domains (9) summary
      cd05738
      Location:143220
      Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      cd05739
      Location:240308
      Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      smart00408
      Location:141208
      IGc2; Immunoglobulin C-2 Type
      smart00194
      Location:9491204
      PTPc; Protein tyrosine phosphatase, catalytic domain
      smart00409
      Location:232309
      IG; Immunoglobulin
      cd00047
      Location:9751204
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:313402
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:24115
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:41115
      Ig; Immunoglobulin domain
    3. NM_002839.3NP_002830.1  receptor-type tyrosine-protein phosphatase delta isoform 1 precursor

      See identical proteins and their annotated locations for NP_002830.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AB211400, AL356584, AL390723, AL445926, BC028038, BM680342
      Consensus CDS
      CCDS43786.1
      UniProtKB/Swiss-Prot
      P23468
      UniProtKB/TrEMBL
      Q2HXI4
      Related
      ENSP00000370593, OTTHUMP00000022727, ENST00000381196, OTTHUMT00000055395
      Conserved Domains (9) summary
      cd05738
      Location:143226
      Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      cd05739
      Location:250318
      Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      smart00408
      Location:141214
      IGc2; Immunoglobulin C-2 Type
      smart00194
      Location:13561611
      PTPc; Protein tyrosine phosphatase, catalytic domain
      smart00410
      Location:242319
      IG_like; Immunoglobulin like
      cd00047
      Location:13821611
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:9221013
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:24115
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:41115
      Ig; Immunoglobulin domain
    4. NM_130391.3NP_569075.2  receptor-type tyrosine-protein phosphatase delta isoform 2 precursor

      See identical proteins and their annotated locations for NP_569075.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) has multiple differences in the coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1. The 5' UTR of this variant is incomplete because no 5' complete transcripts representing this variant exist, and there are alternate splicing choices in the upstream region.
      Source sequence(s)
      AL445926, BC106715, BM680342, DR001889
      Consensus CDS
      CCDS6472.2
      UniProtKB/Swiss-Prot
      P23468
      Related
      ENSP00000417093, OTTHUMP00000215416, ENST00000486161, OTTHUMT00000355536
      Conserved Domains (9) summary
      cd05738
      Location:143226
      Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      cd05739
      Location:250318
      Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      smart00408
      Location:141214
      IGc2; Immunoglobulin C-2 Type
      smart00194
      Location:9491204
      PTPc; Protein tyrosine phosphatase, catalytic domain
      smart00410
      Location:242319
      IG_like; Immunoglobulin like
      cd00047
      Location:9751204
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:323412
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:24115
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:41115
      Ig; Immunoglobulin domain
    5. NM_130392.3NP_569076.2  receptor-type tyrosine-protein phosphatase delta isoform 3 precursor

      See identical proteins and their annotated locations for NP_569076.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) has multiple differences in the coding region, compared to variant 1, resulting in an isoform (3) that is shorter than isoform 1. The 5' UTR of this variant is incomplete because no 5' complete transcripts representing this variant exist, and there are alternate splicing choices in the upstream region.
      Source sequence(s)
      AL445926, BC106714, BM680342, DR001889
      Consensus CDS
      CCDS55290.1
      UniProtKB/Swiss-Prot
      P23468
      Related
      ENSP00000347373, ENST00000355233
      Conserved Domains (9) summary
      cd05738
      Location:143226
      Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      cd05739
      Location:250318
      Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      smart00408
      Location:141214
      IGc2; Immunoglobulin C-2 Type
      smart00194
      Location:9501205
      PTPc; Protein tyrosine phosphatase, catalytic domain
      smart00410
      Location:242319
      IG_like; Immunoglobulin like
      cd00047
      Location:9761205
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:323412
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:24115
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:41115
      Ig; Immunoglobulin domain
    6. NM_130393.3NP_569077.2  receptor-type tyrosine-protein phosphatase delta isoform 4 precursor

      See identical proteins and their annotated locations for NP_569077.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) has multiple differences in the coding region, compared to variant 1, resulting in an isoform (4) that is shorter than isoform 1. The 5' UTR of this variant is incomplete because no 5' complete transcripts representing this variant exist, and there are alternate splicing choices in the upstream region.
      Source sequence(s)
      AL445926, AL590397, BC106716, BM680342, DR001889
      Consensus CDS
      CCDS75813.1
      UniProtKB/TrEMBL
      Q3KPI9
      Related
      ENSP00000440515, ENST00000537002
      Conserved Domains (9) summary
      cd05738
      Location:143220
      Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      cd05739
      Location:244312
      Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      smart00408
      Location:141208
      IGc2; Immunoglobulin C-2 Type
      smart00194
      Location:9401195
      PTPc; Protein tyrosine phosphatase, catalytic domain
      smart00409
      Location:236313
      IG; Immunoglobulin
      cd00047
      Location:9661195
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:317406
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:24115
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:41115
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p7 Primary Assembly

      Range
      8314246..10612840 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017014965.1XP_016870454.1  

    2. XM_006716817.3XP_006716880.1  

      Conserved Domains (9) summary
      cd05738
      Location:143226
      Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      cd05739
      Location:250318
      Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      smart00408
      Location:141214
      IGc2; Immunoglobulin C-2 Type
      smart00194
      Location:13731628
      PTPc; Protein tyrosine phosphatase, catalytic domain
      smart00410
      Location:242319
      IG_like; Immunoglobulin like
      cd00047
      Location:13991628
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:9221013
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:24115
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:41115
      Ig; Immunoglobulin domain
    3. XM_017014961.1XP_016870450.1  

    4. XM_017014960.1XP_016870449.1  

    5. XM_017014966.1XP_016870455.1  

    6. XM_017014969.1XP_016870458.1  

    7. XM_017014974.1XP_016870463.1  

    8. XM_017014972.1XP_016870461.1  

    9. XM_017014970.1XP_016870459.1  

    10. XM_017014963.1XP_016870452.1  

    11. XM_017014958.1XP_016870447.1  

    12. XM_017014959.1XP_016870448.1  

    13. XM_017014964.1XP_016870453.1  

    14. XM_017014979.1XP_016870468.1  

    15. XM_017014971.1XP_016870460.1  

    16. XM_017014967.1XP_016870456.1  

    17. XM_017014977.1XP_016870466.1  

    18. XM_017014973.1XP_016870462.1  

    19. XM_006716825.3XP_006716888.1  

      Conserved Domains (9) summary
      cd05738
      Location:143226
      Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      cd05739
      Location:250318
      Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      smart00408
      Location:141214
      IGc2; Immunoglobulin C-2 Type
      smart00194
      Location:13561611
      PTPc; Protein tyrosine phosphatase, catalytic domain
      smart00410
      Location:242319
      IG_like; Immunoglobulin like
      cd00047
      Location:13821611
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:9221013
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:24115
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:41115
      Ig; Immunoglobulin domain
    20. XM_017014968.1XP_016870457.1  

    21. XM_017014976.1XP_016870465.1  

    22. XM_017014984.1XP_016870473.1  

    23. XM_017014983.1XP_016870472.1  

    24. XM_017014982.1XP_016870471.1  

    25. XM_017014975.1XP_016870464.1  

    26. XM_017014995.1XP_016870484.1  

    27. XM_006716823.2XP_006716886.1  

      Conserved Domains (9) summary
      cd05738
      Location:143226
      Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      cd05739
      Location:250318
      Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      smart00408
      Location:141214
      IGc2; Immunoglobulin C-2 Type
      smart00194
      Location:13571612
      PTPc; Protein tyrosine phosphatase, catalytic domain
      smart00410
      Location:242319
      IG_like; Immunoglobulin like
      cd00047
      Location:13831612
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:9221013
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:24115
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:41115
      Ig; Immunoglobulin domain
    28. XM_006716827.3XP_006716890.1  

      Conserved Domains (9) summary
      cd05738
      Location:143217
      Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      cd05739
      Location:237305
      Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      smart00408
      Location:141205
      IGc2; Immunoglobulin C-2 Type
      smart00194
      Location:13371592
      PTPc; Protein tyrosine phosphatase, catalytic domain
      smart00410
      Location:229306
      IG_like; Immunoglobulin like
      cd00047
      Location:13631592
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:900991
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:24115
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:41115
      Ig; Immunoglobulin domain
    29. XM_017014980.1XP_016870469.1  

    30. XM_011517992.2XP_011516294.1  

      See identical proteins and their annotated locations for XP_011516294.1

      UniProtKB/Swiss-Prot
      P23468
      Conserved Domains (9) summary
      cd05738
      Location:143226
      Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      cd05739
      Location:250318
      Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      smart00408
      Location:141214
      IGc2; Immunoglobulin C-2 Type
      smart00194
      Location:13561611
      PTPc; Protein tyrosine phosphatase, catalytic domain
      smart00410
      Location:242319
      IG_like; Immunoglobulin like
      cd00047
      Location:13821611
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:9221013
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:24115
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:41115
      Ig; Immunoglobulin domain
    31. XM_017014985.1XP_016870474.1  

    32. XM_006716834.3XP_006716897.1  

      Conserved Domains (9) summary
      cd05738
      Location:143217
      Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      cd05739
      Location:237305
      Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      smart00408
      Location:141205
      IGc2; Immunoglobulin C-2 Type
      smart00194
      Location:9491204
      PTPc; Protein tyrosine phosphatase, catalytic domain
      smart00410
      Location:229306
      IG_like; Immunoglobulin like
      cd00047
      Location:9751204
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:310399
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:24115
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:41115
      Ig; Immunoglobulin domain
    33. XM_017014988.1XP_016870477.1  

    34. XM_017014987.1XP_016870476.1  

    35. XM_017014986.1XP_016870475.1  

    36. XM_017014989.1XP_016870478.1  

    37. XM_006716838.3XP_006716901.1  

      Conserved Domains (9) summary
      cd05738
      Location:143217
      Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      cd05739
      Location:241309
      Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      smart00408
      Location:141205
      IGc2; Immunoglobulin C-2 Type
      smart00194
      Location:9391194
      PTPc; Protein tyrosine phosphatase, catalytic domain
      smart00410
      Location:233310
      IG_like; Immunoglobulin like
      cd00047
      Location:9651194
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:314403
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:24115
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:41115
      Ig; Immunoglobulin domain
    38. XM_006716835.3XP_006716898.1  

      See identical proteins and their annotated locations for XP_006716898.1

      UniProtKB/Swiss-Prot
      P23468
      Conserved Domains (9) summary
      cd05738
      Location:143223
      Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      cd05739
      Location:247315
      Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      smart00408
      Location:141211
      IGc2; Immunoglobulin C-2 Type
      smart00194
      Location:9461201
      PTPc; Protein tyrosine phosphatase, catalytic domain
      smart00410
      Location:239316
      IG_like; Immunoglobulin like
      cd00047
      Location:9721201
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:320409
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:24115
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:41115
      Ig; Immunoglobulin domain
    39. XM_006716833.3XP_006716896.1  

      See identical proteins and their annotated locations for XP_006716896.1

      UniProtKB/Swiss-Prot
      P23468
      Conserved Domains (9) summary
      cd05738
      Location:143226
      Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      cd05739
      Location:250318
      Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      smart00408
      Location:141214
      IGc2; Immunoglobulin C-2 Type
      smart00194
      Location:9491204
      PTPc; Protein tyrosine phosphatase, catalytic domain
      smart00410
      Location:242319
      IG_like; Immunoglobulin like
      cd00047
      Location:9751204
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:323412
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:24115
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:41115
      Ig; Immunoglobulin domain
    40. XM_017014991.1XP_016870480.1  

    41. XM_006716839.3XP_006716902.1  

      Conserved Domains (9) summary
      cd05738
      Location:143217
      Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      cd05739
      Location:237305
      Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      smart00408
      Location:141205
      IGc2; Immunoglobulin C-2 Type
      smart00194
      Location:9351190
      PTPc; Protein tyrosine phosphatase, catalytic domain
      smart00410
      Location:229306
      IG_like; Immunoglobulin like
      cd00047
      Location:9611190
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:310399
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:24115
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:41115
      Ig; Immunoglobulin domain
    42. XM_017014981.1XP_016870470.1  

    43. XM_006716832.3XP_006716895.1  

      See identical proteins and their annotated locations for XP_006716895.1

      UniProtKB/Swiss-Prot
      P23468
      Conserved Domains (9) summary
      cd05738
      Location:143220
      Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      cd05739
      Location:240308
      Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      smart00408
      Location:141208
      IGc2; Immunoglobulin C-2 Type
      smart00194
      Location:9491204
      PTPc; Protein tyrosine phosphatase, catalytic domain
      smart00409
      Location:232309
      IG; Immunoglobulin
      cd00047
      Location:9751204
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:313402
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:24115
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:41115
      Ig; Immunoglobulin domain
    44. XM_006716837.3XP_006716900.1  

      See identical proteins and their annotated locations for XP_006716900.1

      UniProtKB/TrEMBL
      Q3KPI9
      Conserved Domains (9) summary
      cd05738
      Location:143220
      Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      cd05739
      Location:244312
      Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      smart00408
      Location:141208
      IGc2; Immunoglobulin C-2 Type
      smart00194
      Location:9401195
      PTPc; Protein tyrosine phosphatase, catalytic domain
      smart00409
      Location:236313
      IG; Immunoglobulin
      cd00047
      Location:9661195
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:317406
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:24115
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:41115
      Ig; Immunoglobulin domain
    45. XM_017014994.1XP_016870483.1  

    46. XM_017014993.1XP_016870482.1  

    47. XM_017014962.1XP_016870451.1  

    48. XM_017014978.1XP_016870467.1  

    49. XM_017014992.1XP_016870481.1  

    50. XM_017014990.1XP_016870479.1  

    Alternate CHM1_1.1

    Genomic

    1. NC_018920.2 Alternate CHM1_1.1

      Range
      8314050..10612534 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)