Display Settings:

Format

Send to:

Choose Destination
    • Showing Current items.

    Cttn cortactin [ Mus musculus (house mouse) ]

    Gene ID: 13043, updated on 11-Jul-2015
    Official Symbol
    Cttnprovided by MGI
    Official Full Name
    cortactinprovided by MGI
    Primary source
    MGI:MGI:99695
    See related
    Ensembl:ENSMUSG00000031078; Vega:OTTMUSG00000016455
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ems1; 1110020L01Rik
    Orthologs
    See Cttn in Epigenomics, MapViewer
    Location:
    7; 7 F5
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    105 current GRCm38.p3 (GCF_000001635.23) 7 NC_000073.6 (144435723..144471004, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (151621629..151656646, complement)

    Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene SH3/ankyrin domain gene 2 Neighboring gene predicted gene, 34621 Neighboring gene predicted gene, 34561 Neighboring gene protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 Neighboring gene predicted gene, 35626 Neighboring gene Fas (TNFRSF6)-associated via death domain

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    profilin binding ISO
    Inferred from Sequence Orthology
    more info
     
    proline-rich region binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    actin cytoskeleton reorganization ISO
    Inferred from Sequence Orthology
    more info
     
    actin filament polymerization IEA
    Inferred from Electronic Annotation
    more info
     
    cell motility ISO
    Inferred from Sequence Orthology
    more info
     
    dendritic spine maintenance IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    endocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    focal adhesion assembly ISO
    Inferred from Sequence Orthology
    more info
     
    intracellular protein transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    intracellular protein transport ISO
    Inferred from Sequence Orthology
    more info
     
    lamellipodium organization ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of extrinsic apoptotic signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    neuron projection morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of actin filament polymerization ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of smooth muscle contraction ISO
    Inferred from Sequence Orthology
    more info
     
    receptor-mediated endocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of axon extension ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of mitophagy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    substrate-dependent cell migration, cell extension IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    colocalizes_with actin filament ISO
    Inferred from Sequence Orthology
    more info
     
    cell IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell cortex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell cortex ISO
    Inferred from Sequence Orthology
    more info
     
    cell junction ISO
    Inferred from Sequence Orthology
    more info
     
    cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    coated pit ISO
    Inferred from Sequence Orthology
    more info
     
    cortical cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    focal adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with focal adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with growth cone ISO
    Inferred from Sequence Orthology
    more info
     
    intracellular IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    lamellipodium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lamellipodium ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    mitotic spindle midzone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    ruffle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with voltage-gated potassium channel complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with voltage-gated potassium channel complex ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    src substrate cortactin
    Names
    mammary tumor and squamous cell carcinoma associated (p80/85 src substrate)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001252572.1NP_001239501.1  src substrate cortactin isoform 2

      See identical proteins and their annotated locations for NP_001239501.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon in the coding region, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to isoform 1.
      Source sequence(s)
      AK084249, AK168871, AK168945, BY137811, BY265697, BY760295
      Consensus CDS
      CCDS57599.1
      UniProtKB/TrEMBL
      Q8BNA5
      UniProtKB/TrEMBL
      Q921L6
      Related
      ENSMUSP00000033407, OTTMUSP00000017696, ENSMUST00000033407, OTTMUST00000039646
      Conserved Domains (4) summary
      pfam02218
      Location:157193
      HS1_rep; Repeat in HS1/Cortactin
      cd11959
      Location:455507
      SH3_Cortactin; Src homology 3 domain of Cortactin
      pfam15552
      Location:350423
      DUF4657; Domain of unknown function (DUF4657)
      cl15270
      Location:318379
      FinO_conjug_rep; FinO bacterial conjugation repressor domain; the basic protein FinO is part of the the two component FinOP system which is responsible for repressing bacterial conjugation; the FinOP system represses the transfer (tra) operon of the F-plasmid which ...
    2. NM_007803.5NP_031829.2  src substrate cortactin isoform 1

      See identical proteins and their annotated locations for NP_031829.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and it encodes the longer protein (isoform 1).
      Source sequence(s)
      AK168699, BY137811, BY265697, BY760295
      Consensus CDS
      CCDS22049.1
      UniProtKB/Swiss-Prot
      Q60598
      Related
      ENSMUSP00000099368, OTTMUSP00000017695, ENSMUST00000103079, OTTMUST00000039645
      Conserved Domains (4) summary
      pfam02218
      Location:157193
      HS1_rep; Repeat in HS1/Cortactin
      cd11959
      Location:492544
      SH3_Cortactin; Src homology 3 domain of Cortactin
      pfam07946
      Location:345400
      DUF1682; Protein of unknown function (DUF1682)
      pfam15552
      Location:387460
      DUF4657; Domain of unknown function (DUF4657)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p3 C57BL/6J

    Genomic

    1. NC_000073.6 Reference GRCm38.p3 C57BL/6J

      Range
      144435723..144471004
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006508473.1XP_006508536.1  

      Conserved Domains (4) summary
      pfam02218
      Location:157193
      HS1_rep; Repeat in HS1/Cortactin
      cd11959
      Location:418470
      SH3_Cortactin; Src homology 3 domain of Cortactin
      pfam07946
      Location:271326
      DUF1682; Protein of unknown function (DUF1682)
      pfam15552
      Location:313386
      DUF4657; Domain of unknown function (DUF4657)
    2. XM_006508475.2XP_006508538.1  

      Conserved Domains (1) summary
      pfam02218
      Location:157193
      HS1_rep; Repeat in HS1/Cortactin
    3. XM_006508474.2XP_006508537.1  

      Conserved Domains (1) summary
      pfam02218
      Location:157193
      HS1_rep; Repeat in HS1/Cortactin
    4. XM_011241978.1XP_011240280.1  

      Conserved Domains (1) summary
      pfam02218
      Location:157193
      HS1_rep; Repeat in HS1/Cortactin

    Alternate Mm_Celera

    Genomic

    1. AC_000029.1 Alternate Mm_Celera

      Range
      144198389..144233617
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)