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PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 [ Homo sapiens (human) ]

Gene ID: 5300, updated on 19-Jul-2014
Official Symbol
PIN1provided by HGNC
Official Full Name
peptidylprolyl cis/trans isomerase, NIMA-interacting 1provided by HGNC
Primary source
HGNC:8988
See related
Ensembl:ENSG00000127445; HPRD:03031; MIM:601052; Vega:OTTHUMG00000180388
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DOD; UBL5
Summary
Peptidyl-prolyl cis/trans isomerases (PPIases) catalyze the cis/trans isomerization of peptidyl-prolyl peptide bonds. This gene encodes one of the PPIases, which specifically binds to phosphorylated ser/thr-pro motifs to catalytically regulate the post-phosphorylation conformation of its substrates. The conformational regulation catalyzed by this PPIase has a profound impact on key proteins involved in the regulation of cell growth, genotoxic and other stress responses, the immune response, induction and maintenance of pluripotency, germ cell development, neuronal differentiation, and survival. This enzyme also plays a key role in the pathogenesis of Alzheimer's disease and many cancers. Multiple alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jun 2011]
See PIN1 in Epigenomics, MapViewer
Location:
19p13
Exon count:
5
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 19 NC_000019.10 (9835207..9849689)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (9945883..9960365)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100996288 Neighboring gene ubiquitin-like 5 Neighboring gene olfactomedin 2 Neighboring gene collagen, type V, alpha 3

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Vif vif HIV-1 Vif(-) expression cooperates with Pin1 resulting in the reduction of A3G levels and the decreased incorporation of A3G into virions, suggesting the interaction between HIV-1 Vif and A3G PubMed
capsid gag Phosphorylation of HIV-1 CA at serine residue 16 is involved in the HIV-1 core uncoating process. Interaction of PIN1 with the CA core within the target cells is required for the uncoating process PubMed
integrase gag-pol HIV-1 IN is incapable of binding Pin1 Y23A mutant. The catalytically inactive Pin1 C113A mutant can bind HIV-1 IN, but completely ineffective at modifying IN sensitivity to subtilisin PubMed
gag-pol Cellular Pin1 binds phosphorylated HIV-1 IN wild type and controls IN stability, but not S57A IN mutant PubMed

Go to the HIV-1, Human Protein Interaction Database

  • Antiviral mechanism by IFN-stimulated genes, organism-specific biosystem (from REACTOME)
    Antiviral mechanism by IFN-stimulated genes, organism-specific biosystemThe ISG proteins generated by IFN pathways plays key roles in the induction of innate and adaptive immune responses.
  • C-MYC pathway, organism-specific biosystem (from Pathway Interaction Database)
    C-MYC pathway, organism-specific biosystem
    C-MYC pathway
  • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
    Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
  • ISG15 antiviral mechanism, organism-specific biosystem (from REACTOME)
    ISG15 antiviral mechanism, organism-specific biosystemInterferon-stimulated gene 15 (ISG15) is a member of the ubiquitin-like (Ubl) family. It is strongly induced upon exposure to type I Interferons (IFNs), viruses, bacterial LPS, and other stresses. On...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Innate Immune System, organism-specific biosystem (from REACTOME)
    Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
  • Interferon Signaling, organism-specific biosystem (from REACTOME)
    Interferon Signaling, organism-specific biosystemInterferons (IFNs) are cytokines that play a central role in initiating immune responses, especially antiviral and antitumor effects. There are three types of IFNs:Type I (IFN-alpha, -beta and others...
  • Negative regulators of RIG-I/MDA5 signaling, organism-specific biosystem (from REACTOME)
    Negative regulators of RIG-I/MDA5 signaling, organism-specific biosystemAs with other cytokine systems, production of type I IFN is a transient process, and can be hazardous to the host if unregulated, resulting in chronic cellular toxicity or inflammatory and autoimmune...
  • RIG-I-like receptor signaling pathway, organism-specific biosystem (from KEGG)
    RIG-I-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting viral pathogens and generating innate immune responses. Non-self RNA appearing in a cell as a result of intracellular ...
  • RIG-I-like receptor signaling pathway, conserved biosystem (from KEGG)
    RIG-I-like receptor signaling pathway, conserved biosystemSpecific families of pattern recognition receptors are responsible for detecting viral pathogens and generating innate immune responses. Non-self RNA appearing in a cell as a result of intracellular ...
  • RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways, organism-specific biosystem (from REACTOME)
    RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways, organism-specific biosystemRIG-I-like helicases (RLHs) the retinoic acid inducible gene-I (RIG-I) and melanoma differentiation associated gene 5 (MDA5) are RNA helicases that recognize viral RNA present within the cytoplasm. F...
  • Wnt Signaling Pathway NetPath, organism-specific biosystem (from WikiPathways)
    Wnt Signaling Pathway NetPath, organism-specific biosystemWnt family of proteins are a large family of cysteine-rich secreted glycoproteins that regulate cell-cell interactions. They bind to members of the Frizzled family of 7 transmembrane receptors. Bindi...
  • p53 pathway, organism-specific biosystem (from Pathway Interaction Database)
    p53 pathway, organism-specific biosystem
    p53 pathway
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ40239, FLJ77628, MGC10717

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTPase activating protein binding IPI
Inferred from Physical Interaction
more info
 
mitogen-activated protein kinase kinase binding IPI
Inferred from Physical Interaction
more info
 
peptidyl-prolyl cis-trans isomerase activity IDA
Inferred from Direct Assay
more info
PubMed 
phosphoserine binding IDA
Inferred from Direct Assay
more info
PubMed 
phosphothreonine binding IDA
Inferred from Direct Assay
more info
PubMed 
phosphothreonine binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cell cycle IEA
Inferred from Electronic Annotation
more info
 
cytokine-mediated signaling pathway TAS
Traceable Author Statement
more info
 
innate immune response TAS
Traceable Author Statement
more info
 
negative regulation of ERK1 and ERK2 cascade IDA
Inferred from Direct Assay
more info
 
negative regulation of cell motility IDA
Inferred from Direct Assay
more info
 
negative regulation of transforming growth factor beta receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of type I interferon production TAS
Traceable Author Statement
more info
 
positive regulation of Rho GTPase activity IMP
Inferred from Mutant Phenotype
more info
 
positive regulation of protein phosphorylation IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein folding IEA
Inferred from Electronic Annotation
more info
 
protein peptidyl-prolyl isomerization IDA
Inferred from Direct Assay
more info
PubMed 
protein peptidyl-prolyl isomerization IEA
Inferred from Electronic Annotation
more info
 
regulation of cytokinesis IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of cytokinesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of mitosis TAS
Traceable Author Statement
more info
PubMed 
regulation of pathway-restricted SMAD protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
midbody IDA
Inferred from Direct Assay
more info
PubMed 
nuclear speck IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
 
Preferred Names
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1
Names
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1
PPIase Pin1
rotamase Pin1
protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1
NP_006212.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029167.1 

    Range
    5001..19483
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_006221.3NP_006212.1  peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

    See proteins identical to NP_006212.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript and encodes the functional protein.
    Source sequence(s)
    AK291074, BI827672, CA439440
    Consensus CDS
    CCDS12220.1
    UniProtKB/Swiss-Prot
    Q13526
    Related
    ENSP00000247970, OTTHUMP00000264175, ENST00000247970, OTTHUMT00000451107
    Conserved Domains (3) summary
    COG0760
    Location:53159
    Blast Score: 166
    SurA; Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]
    cd00201
    Location:837
    Blast Score: 139
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    cl08278
    Location:51162
    Blast Score: 407
    Rotamase_2; PPIC-type PPIASE domain

RNA

  1. NR_038422.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) includes an alternate exon, compared to variant 1, resulting in a premature stop codon. The transcript is predicted to be subject to nonsense-mediated decay (NMD).
    Source sequence(s)
    BC002899, BI827672, CA439440, CD675162
  2. NR_038830.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) includes an alternate exon in the 5' region, resulting in a premature stop codon, and lacks a segment in the 3' region, compared to variant 1. The transcript is predicted to be subject to nonsense-mediated decay (NMD).
    Source sequence(s)
    BC031971, BG912418, BI827672, CA439440, CD675162

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000019.10 

    Range
    9835207..9849689
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000151.1 

    Range
    9526513..9540997
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018930.2 

    Range
    9945595..9960077
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)