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AGER advanced glycosylation end product-specific receptor [ Homo sapiens (human) ]

Gene ID: 177, updated on 7-Dec-2014
Official Symbol
AGERprovided by HGNC
Official Full Name
advanced glycosylation end product-specific receptorprovided by HGNC
Primary source
HGNC:HGNC:320
Locus tag
DAMA-358M23.4
See related
Ensembl:ENSG00000204305; HPRD:02568; MIM:600214; Vega:OTTHUMG00000031120
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RAGE
Summary
The advanced glycosylation end product (AGE) receptor encoded by this gene is a member of the immunoglobulin superfamily of cell surface receptors. It is a multiligand receptor, and besides AGE, interacts with other molecules implicated in homeostasis, development, and inflammation, and certain diseases, such as diabetes and Alzheimer's disease. Many alternatively spliced transcript variants encoding different isoforms, as well as non-protein-coding variants, have been described for this gene (PMID:18089847). [provided by RefSeq, May 2011]
See AGER in Epigenomics, MapViewer
Location:
6p21.3
Exon count:
11
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 6 NC_000006.12 (32180968..32184322, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (32148745..32152099, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene 1-acylglycerol-3-phosphate O-acyltransferase 1 Neighboring gene microRNA 6721 Neighboring gene microRNA 6833 Neighboring gene ring finger protein 5, E3 ubiquitin protein ligase Neighboring gene pre-B-cell leukemia homeobox 2 Neighboring gene G-protein signaling modulator 3 Neighboring gene notch 4

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Genome-wide association study identifies five loci associated with lung function.
NHGRI GWA Catalog
Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function.
NHGRI GWA Catalog
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
NHGRI GWA Catalog
Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function.
NHGRI GWA Catalog
  • AGE/RAGE pathway, organism-specific biosystem (from WikiPathways)
    AGE/RAGE pathway, organism-specific biosystemAdvanced glycation end products (AGEs) are heterogeneous group of non-enzymatic malliard reaction products of aldose sugar with proteins and lipids. Formation of AGEs is an indicator of one of the ma...
  • Activated TLR4 signalling, organism-specific biosystem (from REACTOME)
    Activated TLR4 signalling, organism-specific biosystemTLR4 is unique among the TLR family in its ability to recruit four adapters to activate two distinct signaling pathways. One pathway is activated by the pair of the adapters Mal or TIRAP (Toll/inter...
  • Advanced glycosylation endproduct receptor signaling, organism-specific biosystem (from REACTOME)
    Advanced glycosylation endproduct receptor signaling, organism-specific biosystemAdvanced Glycosylation End- product-specific Receptor (AGER) also known as Receptor for Advanced Glycation End-products (RAGE) is a multi-ligand membrane receptor belonging to the immunoglobulin supe...
  • Cytosolic sensors of pathogen-associated DNA, organism-specific biosystem (from REACTOME)
    Cytosolic sensors of pathogen-associated DNA, organism-specific biosystemPresence of pathogen-associated DNA in cytosol induces type I IFN production. Several intracellular receptors have been implicated to some degree. These include DNA-dependent activator of interferon ...
  • DEx/H-box helicases activate type I IFN and inflammatory cytokines production, organism-specific biosystem (from REACTOME)
    DEx/H-box helicases activate type I IFN and inflammatory cytokines production, organism-specific biosystemDHX36 and DHX9 are aspartate-glutamate-any amino acid aspartate/histidine (DExD/H) box helicase (DHX) proteins that localize in the cytosol. The DHX RNA helicases family includes a large number of pr...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Innate Immune System, organism-specific biosystem (from REACTOME)
    Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
  • MyD88 cascade initiated on plasma membrane, organism-specific biosystem (from REACTOME)
    MyD88 cascade initiated on plasma membrane, organism-specific biosystemMammalian myeloid differentiation factor 88 (MyD88) is Toll/interleukin (IL)-1 (TIR)-domain containing adapter protein which plays crucial role in TLR signaling. All TLRs, with only one exception of...
  • MyD88 dependent cascade initiated on endosome, organism-specific biosystem (from REACTOME)
    MyD88 dependent cascade initiated on endosome, organism-specific biosystemUpon binding of their ligands, TLR7/8 and TLR9 recruit a cytoplasmic adaptor MyD88 and IRAKs, downstream of which the signaling pathways are divided to induce either inflammatory cytokines or type I ...
  • MyD88-independent cascade, organism-specific biosystem (from REACTOME)
    MyD88-independent cascade, organism-specific biosystemMyD88-independent signaling pathway is shared by TLR3 and TLR4 cascades. TIR-domain-containing adapter-inducing interferon-beta (TRIF or TICAM1) is a key adapter molecule in transducing signals from ...
  • MyD88:Mal cascade initiated on plasma membrane, organism-specific biosystem (from REACTOME)
    MyD88:Mal cascade initiated on plasma membrane, organism-specific biosystemThe first known downstream component of TLR4 and TLR2 signaling is the adaptor MyD88. Another adapter MyD88-adaptor-like (Mal; also known as TIR-domain-containing adaptor protein or TIRAP) has also b...
  • RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways, organism-specific biosystem (from REACTOME)
    RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways, organism-specific biosystemRIG-I-like helicases (RLHs) the retinoic acid inducible gene-I (RIG-I) and melanoma differentiation associated gene 5 (MDA5) are RNA helicases that recognize viral RNA present within the cytoplasm. F...
  • RIP-mediated NFkB activation via ZBP1, organism-specific biosystem (from REACTOME)
    RIP-mediated NFkB activation via ZBP1, organism-specific biosystemOverexpression of human or murine ZBP1 (DAI) in human embryonic kidney 293T cells (HEK293T) activated NF-kB-dependent promoter in a dose-dependent manner. Two RHIM-contaning kinases RIP1 and RIP3 are...
  • TAK1 activates NFkB by phosphorylation and activation of IKKs complex, organism-specific biosystem (from REACTOME)
    TAK1 activates NFkB by phosphorylation and activation of IKKs complex, organism-specific biosystemNF-kappaB is sequestered in the cytoplasm in a complex with inhibitor of NF-kappaB (IkB). Almost all NF-kappaB activation pathways are mediated by IkB kinase (IKK), which phosphorylates IkB resulting...
  • TRAF6 mediated NF-kB activation, organism-specific biosystem (from REACTOME)
    TRAF6 mediated NF-kB activation, organism-specific biosystemThe TRAF6/TAK1 signal activates a canonical IKK complex, resulting in the activation of NF-kB as well as MAPK cascades leading to the activation of AP-1. Although TRAF6/TAK1 has been implicated in To...
  • TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation, organism-specific biosystem (from REACTOME)
    TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation, organism-specific biosystemTRAF6 mediates NFkB activation via canonical phosphorylation of IKK complex by TAK1. TRAF6 and TAK1 also regulate MAPK cascades leading to the activation of AP-1.
  • TRIF-mediated TLR3/TLR4 signaling, organism-specific biosystem (from REACTOME)
    TRIF-mediated TLR3/TLR4 signaling, organism-specific biosystemTRIF(TICAM1) was shown to induce IRF3/7 and NF-?B activation and apoptosis through distinct intracellular signaling pathways [Han KJ et al 2004; Kaiser WJ and Offermann MK et al 2005]. TRIF consists...
  • Toll Like Receptor 10 (TLR10) Cascade, organism-specific biosystem (from REACTOME)
    Toll Like Receptor 10 (TLR10) Cascade, organism-specific biosystemLittle is known about TLR10 ligands. It has been established that the receptor homodimerizes upon binding and signals in an MyD88-dependent manner (Hasan U et al 2005; Nyman T et al 2008). It may als...
  • Toll Like Receptor 2 (TLR2) Cascade, organism-specific biosystem (from REACTOME)
    Toll Like Receptor 2 (TLR2) Cascade, organism-specific biosystemTLR2 is involved in recognition of peptidoglycan from gram-positive bacteria, bacterial lipoproteins, mycoplasma lipoprotein and mycobacterial products. It is quite possible that recognition of at le...
  • Toll Like Receptor 3 (TLR3) Cascade, organism-specific biosystem (from REACTOME)
    Toll Like Receptor 3 (TLR3) Cascade, organism-specific biosystemToll-like receptor 3 (TLR3) as was shown for mammals is expressed on myeloid dendritic cells, respiratory epithelium, macrophages, and appears to play a central role in mediating the antiviral and in...
  • Toll Like Receptor 4 (TLR4) Cascade, organism-specific biosystem (from REACTOME)
    Toll Like Receptor 4 (TLR4) Cascade, organism-specific biosystemToll-like Receptor 4 is a Microbe Associated Molecular Pattern receptor well known for it's sensitivity to Bacterial Lipopolysaccharides (LPS). LPS is assembled within diverse Gram-negative bacteria,...
  • Toll Like Receptor 5 (TLR5) Cascade, organism-specific biosystem (from REACTOME)
    Toll Like Receptor 5 (TLR5) Cascade, organism-specific biosystemTLR5 is the receptor for flagellin, the protein that forms bacterial flagella. Unlike most other Pathogen-Associated Molecular Patterns (PAMPs), flagellin does not undergo any posttranslational modif...
  • Toll Like Receptor 7/8 (TLR7/8) Cascade, organism-specific biosystem (from REACTOME)
    Toll Like Receptor 7/8 (TLR7/8) Cascade, organism-specific biosystemRNA can serve as a danger signal, both in its double-stranded form (that is associated with viral infection), as well as single-stranded RNA (ssRNA). Specifically, guanosine (G)- and uridine (U)-rich...
  • Toll Like Receptor 9 (TLR9) Cascade, organism-specific biosystem (from REACTOME)
    Toll Like Receptor 9 (TLR9) Cascade, organism-specific biosystemCpG DNA is an unusual Pathogen-Associated Molecular Pattern (PAMP). Cytosine methylation exists in mammalian but not bacterial cells, and most (but not all) CpG in the mammalian genome is methylated....
  • Toll Like Receptor TLR1:TLR2 Cascade, organism-specific biosystem (from REACTOME)
    Toll Like Receptor TLR1:TLR2 Cascade, organism-specific biosystemTLR1 is expressed by monocytes. TLR1 and TLR2 cotranslationally form heterodimeric complexes on the cell surface and in the cytosol. The TLR2:TLR1 complex recognizes Neisserial PorB and Mycobacterial...
  • Toll Like Receptor TLR6:TLR2 Cascade, organism-specific biosystem (from REACTOME)
    Toll Like Receptor TLR6:TLR2 Cascade, organism-specific biosystemTLR2 and TLR4 recognize different bacterial cell wall components. While TLR4 is trained onto Gram-negative lipopolysaccharide components, TLR2 - in combination with TLR6 - plays a major role in recog...
  • Toll-Like Receptors Cascades, organism-specific biosystem (from REACTOME)
    Toll-Like Receptors Cascades, organism-specific biosystemIn human, ten members of the Toll-like receptor (TLR) family (TLR1-TLR10) have been identified (TLR11 has been found in mouse, but not in human). All TLRs have a similar Toll/IL-1 receptor (TIR) doma...
  • ZBP1(DAI) mediated induction of type I IFNs, organism-specific biosystem (from REACTOME)
    ZBP1(DAI) mediated induction of type I IFNs, organism-specific biosystemZ-DNA-binding protein-1 (ZBP1), also known as, DNA-dependent activator of IFN-regulatory factors (DAI) was reported to initiate innate immune responses in murine L929 cells upon stimulation by multip...
  • amb2 Integrin signaling, organism-specific biosystem (from Pathway Interaction Database)
    amb2 Integrin signaling, organism-specific biosystem
    amb2 Integrin signaling
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC22357

Gene Ontology Provided by GOA

Function Evidence Code Pubs
S100 protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
receptor activity TAS
Traceable Author Statement
more info
PubMed 
transmembrane signaling receptor activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
cell surface receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
inflammatory response IEA
Inferred from Electronic Annotation
more info
 
innate immune response TAS
Traceable Author Statement
more info
 
neuron projection development IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of NF-kappaB transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
response to wounding TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
extracellular region IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
Preferred Names
advanced glycosylation end product-specific receptor
Names
advanced glycosylation end product-specific receptor
RAGE isoform sRAGE-delta
RAGE isoform NtRAGE-delta
receptor for advanced glycation end-products variant 20

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029868.1 

    Range
    5001..8355
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001136.4NP_001127.1  advanced glycosylation end product-specific receptor isoform 1 precursor

    See proteins identical to NP_001127.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1, also known as RAGE) represents the predominant transcript, and encodes isoform 1.
    Source sequence(s)
    AK298100, BM971899
    Consensus CDS
    CCDS4746.1
    UniProtKB/TrEMBL
    B4DNX3
    UniProtKB/Swiss-Prot
    Q15109
    Related
    ENSP00000364217, OTTHUMP00000029155, ENST00000375076, OTTHUMT00000076200
    Conserved Domains (4) summary
    cd00096
    Location:255307
    Ig; Immunoglobulin domain
    smart00408
    Location:251306
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:24117
    IG_like; Immunoglobulin like
    pfam08205
    Location:124219
    C2-set_2; CD80-like C2-set immunoglobulin domain
  2. NM_001206929.1NP_001193858.1  advanced glycosylation end product-specific receptor isoform 2 precursor

    See proteins identical to NP_001193858.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2, also known as RAGE_v5) uses an alternate in-frame donor splice site at an internal coding exon compared to variant 1. This results in a longer isoform (2) containing an additional protein segment compared to isoform 1.
    Source sequence(s)
    AK298100, AY755621, BM971899
    Consensus CDS
    CCDS75429.1
    UniProtKB/TrEMBL
    B4DNX3
    UniProtKB/Swiss-Prot
    Q15109
    Related
    ENSP00000364210, ENST00000375069
    Conserved Domains (4) summary
    cd00096
    Location:271323
    Ig; Immunoglobulin domain
    smart00408
    Location:267322
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:24117
    IG_like; Immunoglobulin like
    pfam08205
    Location:124235
    C2-set_2; CD80-like C2-set immunoglobulin domain
  3. NM_001206932.1NP_001193861.1  advanced glycosylation end product-specific receptor isoform 3 precursor

    See proteins identical to NP_001193861.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3, also known as RAGE_v4) uses alternate in-frame acceptor and donor splice sites at two internal coding exons compared to variant 1. This results in a shorter isoform (2) missing two internal protein segments compared to isoform 1.
    Source sequence(s)
    AK298100, AY755624, BM971899
    UniProtKB/TrEMBL
    B4DNX3
    UniProtKB/Swiss-Prot
    Q15109
    Conserved Domains (5) summary
    cd00096
    Location:241293
    Ig; Immunoglobulin domain
    smart00408
    Location:237292
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:24103
    IG_like; Immunoglobulin like
    pfam08205
    Location:110205
    C2-set_2; CD80-like C2-set immunoglobulin domain
    pfam13895
    Location:23103
    Ig_2; Immunoglobulin domain
  4. NM_001206934.1NP_001193863.1  advanced glycosylation end product-specific receptor isoform 4 precursor

    See proteins identical to NP_001193863.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4, also known as RAGE_v6) lacks the penultimate coding exon, and uses alternate donor splice sites at two internal coding exons compared to variant 1. This results in a frame-shift and a shorter isoform (4) with a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AK298100, AY755622, BM971899
    Consensus CDS
    CCDS56417.1
    UniProtKB/TrEMBL
    B4DNX3
    UniProtKB/Swiss-Prot
    Q15109
    Related
    ENSP00000387887, ENST00000438221
    Conserved Domains (4) summary
    cd00096
    Location:271323
    Ig; Immunoglobulin domain
    smart00408
    Location:267322
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:24117
    IG_like; Immunoglobulin like
    pfam08205
    Location:124235
    C2-set_2; CD80-like C2-set immunoglobulin domain
  5. NM_001206936.1NP_001193865.1  advanced glycosylation end product-specific receptor isoform 5 precursor

    See proteins identical to NP_001193865.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5, also known as RAGE_v9) lacks the penultimate coding exon, and uses alternate acceptor and donor splice sites at two internal coding exons compared to variant 1. This results in a frame-shift and a shorter isoform (5) with a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AK298100, AY755623, BM971899
    UniProtKB/TrEMBL
    B4DNX3
    UniProtKB/Swiss-Prot
    Q15109
    Conserved Domains (4) summary
    cd00096
    Location:34111
    Ig; Immunoglobulin domain
    smart00410
    Location:24117
    IG_like; Immunoglobulin like
    pfam08205
    Location:124219
    C2-set_2; CD80-like C2-set immunoglobulin domain
    cl11960
    Location:249281
    Ig; Immunoglobulin domain
  6. NM_001206940.1NP_001193869.1  advanced glycosylation end product-specific receptor isoform 6 precursor

    See proteins identical to NP_001193869.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6, also known as RAGE_v1) lacks the penultimate coding exon, and uses an alternate donor splice site at another coding exon compared to variant 1. This results in a frame-shift and a shorter isoform (6, also known as esRAGE and soluble RAGE) with a distinct C-terminus compared to isoform 1. This isoform lacks the transmembrane and intracellular domains, is secreted (PMID:18089847), and thought to function as a decoy receptor that inhibits RAGE signaling, and thus prevent the pathological progression of some pathologic conditions, such as Alzheimer's disease (PMID:18431028). Variants 6 and 9 encode the same isoform.
    Source sequence(s)
    AK298100, AY755620, BM971899
    Consensus CDS
    CCDS56418.1
    UniProtKB/TrEMBL
    B4DNX3
    UniProtKB/Swiss-Prot
    Q15109
    Related
    ENSP00000364195, OTTHUMP00000174885, ENST00000375055, OTTHUMT00000268937
    Conserved Domains (4) summary
    cd00096
    Location:255307
    Ig; Immunoglobulin domain
    smart00408
    Location:251306
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:24117
    IG_like; Immunoglobulin like
    pfam08205
    Location:124219
    C2-set_2; CD80-like C2-set immunoglobulin domain
  7. NM_001206954.1NP_001193883.1  advanced glycosylation end product-specific receptor isoform 8 precursor

    See proteins identical to NP_001193883.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8, also known as RAGE_v8) lacks two internal coding exons, and uses an alternate donor splice site at another coding exon compared to variant 1. This results in a frame-shift, and a shorter isoform (8) with a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AK298100, BM971899, EU117141
    UniProtKB/TrEMBL
    B4DNX3
    UniProtKB/Swiss-Prot
    Q15109
    Conserved Domains (4) summary
    cd00096
    Location:34111
    Ig; Immunoglobulin domain
    smart00410
    Location:24117
    IG_like; Immunoglobulin like
    pfam00047
    Location:252285
    ig; Immunoglobulin domain
    pfam08205
    Location:124219
    C2-set_2; CD80-like C2-set immunoglobulin domain
  8. NM_001206966.1NP_001193895.1  advanced glycosylation end product-specific receptor isoform 6 precursor

    See proteins identical to NP_001193895.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9, also known as RAGE_v10) lacks the penultimate coding exon, and uses alternate splice sites at other exons at the 3' end compared to variant 1. This results in a frame-shift and a shorter isoform (6, also known as esRAGE and soluble RAGE) with a distinct C-terminus compared to isoform 1. Variants 6 and 9 encode the same isoform.
    Source sequence(s)
    AK298100, AY755628, BM971899
    Consensus CDS
    CCDS56418.1
    UniProtKB/TrEMBL
    B4DNX3
    UniProtKB/Swiss-Prot
    Q15109
    Conserved Domains (4) summary
    cd00096
    Location:255307
    Ig; Immunoglobulin domain
    smart00408
    Location:251306
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:24117
    IG_like; Immunoglobulin like
    pfam08205
    Location:124219
    C2-set_2; CD80-like C2-set immunoglobulin domain
  9. NM_172197.2NP_751947.1  advanced glycosylation end product-specific receptor isoform 7 precursor

    See proteins identical to NP_751947.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7, also known as RAGE_v16) uses alternate splice sites at several internal coding exons compared to variant 1. This results in a frame-shift and a shorter isoform (7, also known as hRAGEsec) with a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AJ133822, AK298100, BM971899
    Consensus CDS
    CCDS4747.1
    UniProtKB/TrEMBL
    B4DNX3
    UniProtKB/Swiss-Prot
    Q15109
    Related
    ENSP00000364208, OTTHUMP00000029156, ENST00000375067, OTTHUMT00000076201
    Conserved Domains (3) summary
    smart00410
    Location:24103
    IG_like; Immunoglobulin like
    pfam08205
    Location:110205
    C2-set_2; CD80-like C2-set immunoglobulin domain
    pfam13895
    Location:23103
    Ig_2; Immunoglobulin domain

RNA

  1. NR_038190.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10, also known as RAGE_v2) is alternatively spliced at the 5' end compared to variant 1. It is represented as non-coding because the use of the 5'-most translation start codon (with a strong Kozak signal), renders this transcript a candidate for nonsense-mediated mRNA decay (NMD). Transfection studies also could not detect expression of any protein from this variant (PMID:18089847).
    Source sequence(s)
    AK298100, BM971899, DQ104254

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000006.12 

    Range
    32180968..32184322
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38 ALT_REF_LOCI_1

Genomic

  1. NT_167244.2 

    Range
    3513570..3516924
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38 ALT_REF_LOCI_2

Genomic

  1. NT_113891.3 

    Range
    3619320..3622674
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38 ALT_REF_LOCI_4

Genomic

  1. NT_167246.2 

    Range
    3485949..3489303
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38 ALT_REF_LOCI_5

Genomic

  1. NT_167247.2 

    Range
    3522987..3526341
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38 ALT_REF_LOCI_6

Genomic

  1. NT_167248.2 

    Range
    3404169..3407523
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38 ALT_REF_LOCI_7

Genomic

  1. NT_167249.2 

    Range
    3497175..3500529
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018917.2 

    Range
    32151229..32154583
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000138.1 

    Range
    31902943..31906297
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)