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MTOR mechanistic target of rapamycin (serine/threonine kinase) [ Homo sapiens (human) ]

Gene ID: 2475, updated on 18-Aug-2014
Official Symbol
MTORprovided by HGNC
Official Full Name
mechanistic target of rapamycin (serine/threonine kinase)provided by HGNC
Primary source
HGNC:3942
See related
Ensembl:ENSG00000198793; HPRD:03134; MIM:601231; Vega:OTTHUMG00000002001
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FRAP; FRAP1; FRAP2; RAFT1; RAPT1
Summary
The protein encoded by this gene belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. The ANGPTL7 gene is located in an intron of this gene. [provided by RefSeq, Sep 2008]
See MTOR in Epigenomics, MapViewer
Location:
1p36.2
Exon count:
59
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 1 NC_000001.11 (11106531..11262557, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (11166588..11322614, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene exosome component 10 Neighboring gene spermidine synthase Neighboring gene MTOR antisense RNA 1 Neighboring gene angiopoietin-like 7 Neighboring gene ribosomal protein L39 pseudogene 6 Neighboring gene ubiquitin-conjugating enzyme E2 variant 2 pseudgene 3 Neighboring gene UbiA prenyltransferase domain containing 1 Neighboring gene patched domain containing 2

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Association of variants in FRAP1 and PDGFRA with corneal curvature in Asian populations from Singapore.
NHGRI GWA Catalog

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Syncytia arising from the fusion of cells expressing HIV-1 gp120 with cells expressing the CD4/CXCR4 complex causes phosphorylation of p53, which is mediated by the upregulation of mammalian target of FKBP12-rapamycin-associated protein (FRAP) PubMed
Tat tat HIV-1 Tat induces phosphorylation of mTOR in Tat-expressing cells and HIV-1-infected cells PubMed

Go to the HIV-1, Human Protein Interaction Database

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  • Signaling by Insulin receptor, organism-specific biosystem (from REACTOME)
    Signaling by Insulin receptor, organism-specific biosystemInsulin binding to its receptor results in receptor autophosphorylation on tyrosine residues and the tyrosine phosphorylation of insulin receptor substrates (e.g. IRS and Shc) by the insulin receptor...
  • Signaling by PDGF, organism-specific biosystem (from REACTOME)
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  • Signaling by SCF-KIT, organism-specific biosystem (from REACTOME)
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  • Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R), organism-specific biosystem (from REACTOME)
    Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R), organism-specific biosystemBinding of IGF1 (IGF-I) or IGF2 (IGF-II) to the extracellular alpha peptides of the type 1 insulin-like growth factor receptor (IGF1R) triggers the activation of two major signaling pathways: the SOS...
  • Signaling by VEGF, organism-specific biosystem (from REACTOME)
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  • Signaling by the B Cell Receptor (BCR), organism-specific biosystem (from REACTOME)
    Signaling by the B Cell Receptor (BCR), organism-specific biosystemMature B cells express IgM and IgD immunoglobulins which are complexed at the plasma membrane with Ig-alpha (CD79A, MB-1) and Ig-beta (CD79B, B29) to form the B cell receptor (BCR) (Fu et al. 1974, F...
  • Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met), organism-specific biosystem (from Pathway Interaction Database)
    Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met), organism-specific biosystem
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  • Signalling by NGF, organism-specific biosystem (from REACTOME)
    Signalling by NGF, organism-specific biosystemNeurotrophins (NGF, BDNF, NT-3, NT-4/5) play pivotal roles in survival, differentiation, and plasticity of neurons in the peripheral and central nervous system. They are produced, and secreted in mi...
  • TOR signaling, organism-specific biosystem (from WikiPathways)
    TOR signaling, organism-specific biosystemTOR signaling is responsible for a cellular reaction towards nutrient and energy availability and hypoxia/stress. The mammalian Target Of Rapamycin (mTOR), a serine/threonine kinase, is the central r...
  • TSH signaling pathway, organism-specific biosystem (from WikiPathways)
    TSH signaling pathway, organism-specific biosystemHuman thyroid stimulating hormone (TSH) is a glycoprotein secreted by the anterior part of the pituitary gland (1). TSH plays an important physiological role in the regulation of the hypothalamic-pit...
  • TSLP Signaling Pathway, organism-specific biosystem (from WikiPathways)
    TSLP Signaling Pathway, organism-specific biosystemThymic stromal lymphopoietin (TSLP) is a type I cytokine member of interleukin-2 cytokine family. TSLP signals through interleukin-7 receptor a chain (IL-7Ra) and the TSLP receptor subunit (TSLPR), h...
  • Thyroid hormone signaling pathway, organism-specific biosystem (from KEGG)
    Thyroid hormone signaling pathway, organism-specific biosystemThe thyroid hormones (THs) are important regulators of growth, development and metabolism. The action of TH is mainly mediated by T3 (3,5,3'-triiodo-L-thyronine). Thyroid hormones, L-thyroxine (T4) a...
  • Type II diabetes mellitus, organism-specific biosystem (from KEGG)
    Type II diabetes mellitus, organism-specific biosystemInsulin resistance is strongly associated with type II diabetes. "Diabetogenic" factors including FFA, TNFalpha and cellular stress induce insulin resistance through inhibition of IRS1 functions. Ser...
  • Type II diabetes mellitus, organism-specific biosystem (from WikiPathways)
    Type II diabetes mellitus, organism-specific biosystemInsulin resistance is strongly associated with type II diabetes. "Diabetogenic" factors including FFA, TNFalpha and cellular stress induce insulin resistance through inhibition of IRS1 functions. Ser...
  • Type II diabetes mellitus, conserved biosystem (from KEGG)
    Type II diabetes mellitus, conserved biosystemInsulin resistance is strongly associated with type II diabetes. "Diabetogenic" factors including FFA, TNFalpha and cellular stress induce insulin resistance through inhibition of IRS1 functions. Ser...
  • VEGFA-VEGFR2 Pathway, organism-specific biosystem (from REACTOME)
    VEGFA-VEGFR2 Pathway, organism-specific biosystemAngiogenesis is the formation of new blood vessels from preexisting vasculature. One of the most important proangiogenic factors is vascular endothelial growth factor (VEGF). VEGF exerts its biologic...
  • VEGFR2 mediated vascular permeability, organism-specific biosystem (from REACTOME)
    VEGFR2 mediated vascular permeability, organism-specific biosystemThe free radical nitric oxide (NO), produced by endothelial NO synthase (eNOS), is an important vasoactive substance in normal vascular biology and pathophysiology. It plays an important role in vasc...
  • mTOR signaling pathway, organism-specific biosystem (from KEGG)
    mTOR signaling pathway, organism-specific biosystem
    mTOR signaling pathway
  • mTOR signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
    mTOR signaling pathway, organism-specific biosystem
    mTOR signaling pathway
  • mTOR signaling pathway, conserved biosystem (from KEGG)
    mTOR signaling pathway, conserved biosystem
    mTOR signaling pathway
  • mTOR signalling, organism-specific biosystem (from REACTOME)
    mTOR signalling, organism-specific biosystem
    mTOR signalling
  • mTORC1-mediated signalling, organism-specific biosystem (from REACTOME)
    mTORC1-mediated signalling, organism-specific biosystem
    mTORC1-mediated signalling
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ44809

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
RNA polymerase III type 1 promoter DNA binding IDA
Inferred from Direct Assay
more info
 
RNA polymerase III type 2 promoter DNA binding IDA
Inferred from Direct Assay
more info
 
RNA polymerase III type 3 promoter DNA binding IDA
Inferred from Direct Assay
more info
 
TFIIIC-class transcription factor binding IDA
Inferred from Direct Assay
more info
 
drug binding IEA
Inferred from Electronic Annotation
more info
 
kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
kinase activity TAS
Traceable Author Statement
more info
PubMed 
phosphoprotein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein domain specific binding IEA
Inferred from Electronic Annotation
more info
 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
 
ribosome binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
Fc-epsilon receptor signaling pathway TAS
Traceable Author Statement
more info
 
T cell costimulation TAS
Traceable Author Statement
more info
 
TOR signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell growth IDA
Inferred from Direct Assay
more info
PubMed 
cell growth TAS
Traceable Author Statement
more info
PubMed 
cellular response to hypoxia ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to nutrient levels ISS
Inferred from Sequence or Structural Similarity
more info
 
epidermal growth factor receptor signaling pathway TAS
Traceable Author Statement
more info
 
fibroblast growth factor receptor signaling pathway TAS
Traceable Author Statement
more info
 
germ cell development IEA
Inferred from Electronic Annotation
more info
 
growth NAS
Non-traceable Author Statement
more info
PubMed 
innate immune response TAS
Traceable Author Statement
more info
 
insulin receptor signaling pathway TAS
Traceable Author Statement
more info
 
negative regulation of NFAT protein import into nucleus IEA
Inferred from Electronic Annotation
more info
 
negative regulation of autophagy ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of cell size IEA
Inferred from Electronic Annotation
more info
 
negative regulation of macroautophagy IEA
Inferred from Electronic Annotation
more info
 
neurotrophin TRK receptor signaling pathway TAS
Traceable Author Statement
more info
 
peptidyl-serine phosphorylation IMP
Inferred from Mutant Phenotype
more info
 
peptidyl-threonine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
phosphatidylinositol-mediated signaling TAS
Traceable Author Statement
more info
 
phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of actin filament polymerization IEA
Inferred from Electronic Annotation
more info
 
positive regulation of endothelial cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of lamellipodium assembly IEA
Inferred from Electronic Annotation
more info
 
positive regulation of lipid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of myotube differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of peptidyl-tyrosine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein kinase B signaling IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein phosphorylation IDA
Inferred from Direct Assay
more info
 
positive regulation of stress fiber assembly IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription from RNA polymerase III promoter IMP
Inferred from Mutant Phenotype
more info
 
positive regulation of translation IDA
Inferred from Direct Assay
more info
PubMed 
protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein catabolic process TAS
Traceable Author Statement
more info
PubMed 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of Rac GTPase activity IEA
Inferred from Electronic Annotation
more info
 
regulation of actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of carbohydrate utilization IEA
Inferred from Electronic Annotation
more info
 
regulation of fatty acid beta-oxidation IEA
Inferred from Electronic Annotation
more info
 
regulation of glycogen biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
regulation of protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
regulation of response to food IEA
Inferred from Electronic Annotation
more info
 
response to amino acid IDA
Inferred from Direct Assay
more info
PubMed 
response to nutrient NAS
Non-traceable Author Statement
more info
PubMed 
response to stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
ruffle organization IEA
Inferred from Electronic Annotation
more info
 
signal transduction NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with PML body ISS
Inferred from Sequence or Structural Similarity
more info
 
TORC1 complex IDA
Inferred from Direct Assay
more info
PubMed 
TORC1 complex IMP
Inferred from Mutant Phenotype
more info
 
TORC2 complex IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
endomembrane system IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
lysosomal membrane IDA
Inferred from Direct Assay
more info
PubMed 
lysosome IDA
Inferred from Direct Assay
more info
 
mTOR-FKBP12-rapamycin complex IEA
Inferred from Electronic Annotation
more info
 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
 
phosphatidylinositol 3-kinase complex NAS
Non-traceable Author Statement
more info
PubMed 
Preferred Names
serine/threonine-protein kinase mTOR
Names
serine/threonine-protein kinase mTOR
rapamycin target protein 1
mammalian target of rapamycin
rapamycin and FKBP12 target 1
FKBP-rapamycin associated protein
rapamycin associated protein FRAP2
FKBP12-rapamycin complex-associated protein 1
FK506 binding protein 12-rapamycin associated protein 2
FK506-binding protein 12-rapamycin complex-associated protein 1
NP_004949.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033239.1 

    Range
    5001..161021
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_734

mRNA and Protein(s)

  1. NM_004958.3NP_004949.1  serine/threonine-protein kinase mTOR

    See proteins identical to NP_004949.1

    Status: REVIEWED

    Source sequence(s)
    AA725390, AB209995, BC117166, BP250183, DC403129, L34075, U88966
    Consensus CDS
    CCDS127.1
    UniProtKB/Swiss-Prot
    P42345
    Related
    ENSP00000354558, OTTHUMP00000001983, ENST00000361445, OTTHUMT00000005558
    Conserved Domains (6) summary
    cd05169
    Location:21532431
    Blast Score: 1456
    PIKKc_TOR; TOR (Target of rapamycin), catalytic domain; The TOR catalytic domain subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs), aminoglycoside ...
    COG5032
    Location:3632549
    Blast Score: 2565
    TEL1; Phosphatidylinositol kinase and protein kinases of the PI-3 kinase family [Signal transduction mechanisms / Cell division and chromosome partitioning / Chromatin structure and dynamics / DNA replication, recombination, and repair / Intracellular ...
    pfam02260
    Location:25192549
    Blast Score: 171
    FATC; FATC domain
    pfam08771
    Location:20152114
    Blast Score: 486
    Rapamycin_bind; Rapamycin binding domain
    pfam11865
    Location:8541024
    Blast Score: 534
    DUF3385; Domain of unknown function (DUF3385)
    pfam13513
    Location:748805
    Blast Score: 87
    HEAT_EZ; HEAT-like repeat

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000001.11 

    Range
    11106531..11262557
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005263438.1XP_005263495.1  

    See proteins identical to XP_005263495.1

    UniProtKB/Swiss-Prot
    P42345
    Conserved Domains (6) summary
    cd05169
    Location:21532431
    Blast Score: 1456
    PIKKc_TOR; TOR (Target of rapamycin), catalytic domain; The TOR catalytic domain subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs), aminoglycoside ...
    COG5032
    Location:3632549
    Blast Score: 2565
    TEL1; Phosphatidylinositol kinase and protein kinases of the PI-3 kinase family [Signal transduction mechanisms / Cell division and chromosome partitioning / Chromatin structure and dynamics / DNA replication, recombination, and repair / Intracellular ...
    pfam02260
    Location:25192549
    Blast Score: 171
    FATC; FATC domain
    pfam08771
    Location:20152114
    Blast Score: 486
    Rapamycin_bind; Rapamycin binding domain
    pfam11865
    Location:8541024
    Blast Score: 534
    DUF3385; Domain of unknown function (DUF3385)
    pfam13513
    Location:748805
    Blast Score: 87
    HEAT_EZ; HEAT-like repeat
  2. XM_005263439.2XP_005263496.1  

    Conserved Domains (6) summary
    cd05169
    Location:19262204
    Blast Score: 1454
    PIKKc_TOR; TOR (Target of rapamycin), catalytic domain; The TOR catalytic domain subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs), aminoglycoside ...
    COG5032
    Location:1412322
    Blast Score: 2552
    TEL1; Phosphatidylinositol kinase and protein kinases of the PI-3 kinase family [Signal transduction mechanisms / Cell division and chromosome partitioning / Chromatin structure and dynamics / DNA replication, recombination, and repair / Intracellular ...
    pfam02260
    Location:22922322
    Blast Score: 171
    FATC; FATC domain
    pfam08771
    Location:17881887
    Blast Score: 486
    Rapamycin_bind; Rapamycin binding domain
    pfam11865
    Location:627797
    Blast Score: 532
    DUF3385; Domain of unknown function (DUF3385)
    pfam13513
    Location:521578
    Blast Score: 87
    HEAT_EZ; HEAT-like repeat

RNA

  1. XR_244786.1 RNA Sequence

Alternate HuRef

Genomic

  1. AC_000133.1 

    Range
    10317883..10473910
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018912.2 

    Range
    11154542..11310885
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)