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Nlgn3 neuroligin 3 [ Mus musculus (house mouse) ]

Gene ID: 245537, updated on 9-May-2015
Official Symbol
Nlgn3provided by MGI
Official Full Name
neuroligin 3provided by MGI
Primary source
MGI:MGI:2444609
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
NL3; HNL3; A230085M13Rik
Orthologs
See Nlgn3 in MapViewer
Location:
X; X D
Exon count:
7
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) X NC_000086.7 (101299179..101321350)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) X NC_000086.6 (98494520..98516689)

Chromosome X - NC_000086.7Genomic Context describing neighboring genes Neighboring gene interleukin 2 receptor, gamma chain Neighboring gene mediator complex subunit 12 Neighboring gene predicted gene, 31385 Neighboring gene gap junction protein, beta 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Cell adhesion molecules (CAMs), organism-specific biosystem (from KEGG)
    Cell adhesion molecules (CAMs), organism-specific biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
  • Cell adhesion molecules (CAMs), conserved biosystem (from KEGG)
    Cell adhesion molecules (CAMs), conserved biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...

Markers

Potential readthrough

Included gene: Med12

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
carboxylic ester hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
cell adhesion molecule binding ISO
Inferred from Sequence Orthology
more info
 
neurexin family protein binding IBA
Inferred from Biological aspect of Ancestor
more info
 
neurexin family protein binding ISO
Inferred from Sequence Orthology
more info
 
receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
receptor activity ISO
Inferred from Sequence Orthology
more info
 
scaffold protein binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
adult behavior ISO
Inferred from Sequence Orthology
more info
 
axon extension ISO
Inferred from Sequence Orthology
more info
 
cell adhesion IEA
Inferred from Electronic Annotation
more info
 
learning ISO
Inferred from Sequence Orthology
more info
 
neuron cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
 
neuron cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
oligodendrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of dendritic spine development ISO
Inferred from Sequence Orthology
more info
 
positive regulation of excitatory postsynaptic membrane potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of inhibitory postsynaptic membrane potential ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein localization to synapse ISO
Inferred from Sequence Orthology
more info
 
positive regulation of synapse assembly ISO
Inferred from Sequence Orthology
more info
 
positive regulation of synaptic transmission, glutamatergic IMP
Inferred from Mutant Phenotype
more info
PubMed 
postsynaptic membrane assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
presynaptic membrane assembly ISO
Inferred from Sequence Orthology
more info
 
receptor-mediated endocytosis ISO
Inferred from Sequence Orthology
more info
 
regulation of N-methyl-D-aspartate selective glutamate receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of dendritic spine morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of excitatory postsynaptic membrane potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of inhibitory postsynaptic membrane potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of inhibitory postsynaptic membrane potential ISO
Inferred from Sequence Orthology
more info
 
regulation of long-term synaptic potentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of respiratory gaseous exchange by neurological system process IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of synaptic transmission IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of synaptic transmission, glutamatergic IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of terminal button organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
rhythmic synaptic transmission ISO
Inferred from Sequence Orthology
more info
 
social behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
social behavior ISO
Inferred from Sequence Orthology
more info
 
synapse assembly IBA
Inferred from Biological aspect of Ancestor
more info
 
synapse assembly ISO
Inferred from Sequence Orthology
more info
 
synapse organization IGI
Inferred from Genetic Interaction
more info
PubMed 
synapse organization ISO
Inferred from Sequence Orthology
more info
PubMed 
visual learning IMP
Inferred from Mutant Phenotype
more info
PubMed 
vocalization behavior ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cell junction IEA
Inferred from Electronic Annotation
more info
 
cell surface IBA
Inferred from Biological aspect of Ancestor
more info
 
cell surface ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with dendrite ISO
Inferred from Sequence Orthology
more info
 
endocytic vesicle ISO
Inferred from Sequence Orthology
more info
 
excitatory synapse ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with excitatory synapse ISO
Inferred from Sequence Orthology
more info
 
inhibitory synapse ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with inhibitory synapse ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
integral component of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
synapse IBA
Inferred from Biological aspect of Ancestor
more info
 
synapse ISO
Inferred from Sequence Orthology
more info
PubMed 
Preferred Names
neuroligin-3
Names
neuroligin-3
gliotactin homolog
neuroligin 3 protein

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172932.4NP_766520.2  neuroligin-3 precursor

    See identical proteins and their annotated locations for NP_766520.2

    Status: VALIDATED

    Source sequence(s)
    AK039018, BB619023, BI134434, CF898143
    Consensus CDS
    CCDS30313.1
    UniProtKB/Swiss-Prot
    Q8BYM5
    Conserved Domains (1) summary
    pfam00135
    Location:33601
    COesterase; Carboxylesterase family

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000086.7 Reference GRCm38.p3 C57BL/6J

    Range
    101299179..101321350
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. AC_000042.1 Alternate Mm_Celera

    Range
    88215226..88237795
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)