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GPRC5A G protein-coupled receptor, class C, group 5, member A [ Homo sapiens (human) ]

Gene ID: 9052, updated on 8-Feb-2015
Official Symbol
GPRC5Aprovided by HGNC
Official Full Name
G protein-coupled receptor, class C, group 5, member Aprovided by HGNC
Primary source
HGNC:HGNC:9836
See related
HPRD:16037; MIM:604138
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RAI3; TIG1; RAIG1; GPCR5A; PEIG-1
Summary
This gene encodes a member of the type 3 G protein-coupling receptor family, characterized by the signature 7-transmembrane domain motif. The encoded protein may be involved in interaction between retinoid acid and G protein signalling pathways. Retinoic acid plays a critical role in development, cellular growth, and differentiation. This gene may play a role in embryonic development and epithelial cell differentiation. [provided by RefSeq, Jul 2008]
Orthologs
See GPRC5A in MapViewer
Location:
12p13.1
Exon count:
4
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 12 NC_000012.12 (12891022..12913666)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (13043956..13066600)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene ribosomal protein S6 pseudogene 1 Neighboring gene ribosomal protein L13a pseudogene 20 Neighboring gene microRNA 614 Neighboring gene G protein-coupled receptor, class C, group 5, member D

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • GPCRs, Class C Metabotropic glutamate, pheromone, organism-specific biosystem (from WikiPathways)
    GPCRs, Class C Metabotropic glutamate, pheromone, organism-specific biosystemThis pathway was created using the GPCRDB (Horn et al., 1998), http://www.cmbi.kun.nl/7tm/. The groupings are based on the GPCR phylogenetic tree available from the GPCRDB and the training sets used ...
  • Integrated Pancreatic Cancer Pathway, organism-specific biosystem (from WikiPathways)
    Integrated Pancreatic Cancer Pathway, organism-specific biosystemAn integrated pathway model which displays the protein-protein interactions (PPIs) among the relevant proteins for pancreatic cancer. This pathway is a collection of different mechanistic protein pat...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G-protein coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
G-protein coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasmic vesicle membrane IEA
Inferred from Electronic Annotation
more info
 
extracellular vesicular exosome IDA
Inferred from Direct Assay
more info
PubMed 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
 
Preferred Names
retinoic acid-induced protein 3
Names
retinoic acid-induced protein 3
G protein-coupled receptor, family C, group 5, member A
G-protein coupled receptor family C group 5 member A
TPA induced gene 1
orphan G-protein-coupling receptor PEIG-1
phorbol ester induced protein-1
retinoic acid induced 3
retinoic acid responsive
retinoic acid-induced gene 1 protein

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003979.3NP_003970.1  retinoic acid-induced protein 3

    See proteins identical to NP_003970.1

    Status: REVIEWED

    Source sequence(s)
    AF095448, AI587426, AK122672
    Consensus CDS
    CCDS8657.1
    UniProtKB/Swiss-Prot
    Q8NFJ5
    Conserved Domains (1) summary
    pfam00003
    Location:40268
    7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38 Primary Assembly

    Range
    12891022..12913666
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018923.2 Alternate CHM1_1.1

    Range
    13009322..13031947
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000144.1 Alternate HuRef

    Range
    12813598..12836110
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)