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    RHOB ras homolog family member B [ Homo sapiens (human) ]

    Gene ID: 388, updated on 30-Jun-2015
    Official Symbol
    RHOBprovided by HGNC
    Official Full Name
    ras homolog family member Bprovided by HGNC
    Primary source
    HGNC:HGNC:668
    See related
    Ensembl:ENSG00000143878; HPRD:01321; MIM:165370; Vega:OTTHUMG00000090755
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ARH6; ARHB; RHOH6; MST081; MSTP081
    Orthologs
    See RHOB in Epigenomics, MapViewer
    Location:
    2p24
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 2 NC_000002.12 (20447071..20449445)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (20646835..20649201)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373465 Neighboring gene RNA, 5S ribosomal pseudogene 86 Neighboring gene uncharacterized LOC102724948 Neighboring gene NADH dehydrogenase (ubiquinone) complex I, assembly factor 2 pseudogene Neighboring gene HS1BP3 intronic transcript 1

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    Genome-wide scan identifies TNIP1, PSORS1C1, and RHOB as novel risk loci for systemic sclerosis.
    NHGRI GWA Catalog

    Protein interactions

    Protein Gene Interaction Pubs
    Vpr vpr HIV-1 Vpr-expressing Jurkat T cell clones showed a significant upregulation of RhoB expression PubMed

    Go to the HIV-1, Human Interaction Database

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    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    GDP binding IEA
    Inferred from Electronic Annotation
    more info
     
    GTP binding TAS
    Traceable Author Statement
    more info
    PubMed 
    GTPase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    Rho protein signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    apoptotic process TAS
    Traceable Author Statement
    more info
    PubMed 
    axon guidance TAS
    Traceable Author Statement
    more info
     
    blood coagulation TAS
    Traceable Author Statement
    more info
     
    cell adhesion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cellular response to hydrogen peroxide IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to ionizing radiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    endosome to lysosome transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of cell cycle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    platelet activation TAS
    Traceable Author Statement
    more info
     
    positive regulation of angiogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of small GTPase mediated signal transduction TAS
    Traceable Author Statement
    more info
     
    small GTPase mediated signal transduction TAS
    Traceable Author Statement
    more info
     
    transformed cell apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    cleavage furrow IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
     
    early endosome IEA
    Inferred from Electronic Annotation
    more info
     
    endosome membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endosome membrane TAS
    Traceable Author Statement
    more info
     
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    focal adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    late endosome membrane IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    Preferred Names
    rho-related GTP-binding protein RhoB
    Names
    Aplysia RAS-related homolog 6
    h6
    oncogene RHO H6
    ras homolog gene family, member B
    rho cDNA clone 6

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_004040.3NP_004031.1  rho-related GTP-binding protein RhoB precursor

      See identical proteins and their annotated locations for NP_004031.1

      Status: VALIDATED

      Source sequence(s)
      AC023137, AK124398, AK310813, CA443347
      Consensus CDS
      CCDS1699.1
      UniProtKB/Swiss-Prot
      P62745
      Related
      ENSP00000272233, OTTHUMP00000115947, ENST00000272233, OTTHUMT00000207500
      Conserved Domains (2) summary
      cd01870
      Location:5179
      RhoA_like; Ras homology family A (RhoA)-like includes RhoA, RhoB and RhoC
      pfam00071
      Location:7180
      Ras; Ras family

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p2 Primary Assembly

      Range
      20447071..20449445
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018913.2 Alternate CHM1_1.1

      Range
      20576233..20578608
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)