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Tcf3 transcription factor 3 [ Mus musculus (house mouse) ]

Gene ID: 21423, updated on 24-Dec-2014
Official Symbol
Tcf3provided by MGI
Official Full Name
transcription factor 3provided by MGI
Primary source
MGI:MGI:98510
See related
Ensembl:ENSMUSG00000020167; Vega:OTTMUSG00000019126
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
A1; E12; E2A; E47; ME2; ALF2; Pan1; Pan2; VDIR; TCF-3; Tcfe2a; E12/E47; bHLHb21; AA408400; AW209082
See Tcf3 in Epigenomics, MapViewer
Location:
10 C1; 10 39.72 cM
Exon count:
20
Annotation release Status Assembly Chr Location
104 current GRCm38.p2 (GCF_000001635.22) 10 NC_000076.6 (80409165..80433653, complement)

Chromosome 10 - NC_000076.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 30823 Neighboring gene methyl-CpG binding domain protein 3 Neighboring gene ubiquinol-cytochrome c reductase, complex III subunit XI Neighboring gene one cut domain, family member 3 Neighboring gene ATPase, class I, type 8B, member 3

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
DNA binding ISO
Inferred from Sequence Orthology
more info
 
contributes_to DNA binding ISO
Inferred from Sequence Orthology
more info
 
E-box binding IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to E-box binding IDA
Inferred from Direct Assay
more info
PubMed 
E-box binding ISO
Inferred from Sequence Orthology
more info
 
contributes_to E-box binding ISO
Inferred from Sequence Orthology
more info
 
PDZ domain binding ISO
Inferred from Sequence Orthology
more info
 
RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
RNA polymerase II core promoter proximal region sequence-specific DNA binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
RNA polymerase II core promoter proximal region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription ISO
Inferred from Sequence Orthology
more info
 
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IDA
Inferred from Direct Assay
more info
PubMed 
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IMP
Inferred from Mutant Phenotype
more info
PubMed 
RNA polymerase II distal enhancer sequence-specific DNA binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IMP
Inferred from Mutant Phenotype
more info
PubMed 
bHLH transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
mitogen-activated protein kinase kinase kinase binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein dimerization activity IEA
Inferred from Electronic Annotation
more info
 
protein heterodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
protein heterodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
PubMed 
protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
repressing transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
sequence-specific DNA binding IGI
Inferred from Genetic Interaction
more info
PubMed 
contributes_to sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
sequence-specific DNA binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
sequence-specific DNA binding transcription factor activity TAS
Traceable Author Statement
more info
PubMed 
transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
 
transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
contributes_to transcription regulatory region DNA binding ISO
Inferred from Sequence Orthology
more info
 
vitamin D response element binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
B cell lineage commitment ISO
Inferred from Sequence Orthology
more info
 
Peyer's patch development IGI
Inferred from Genetic Interaction
more info
PubMed 
T cell differentiation in thymus IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell development IGI
Inferred from Genetic Interaction
more info
PubMed 
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
gastrulation IGI
Inferred from Genetic Interaction
more info
PubMed 
histone H3 acetylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
histone H4 acetylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
immunoglobulin V(D)J recombination IMP
Inferred from Mutant Phenotype
more info
PubMed 
immunoglobulin V(D)J recombination ISO
Inferred from Sequence Orthology
more info
PubMed 
lymphocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
natural killer cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
nervous system development IEA
Inferred from Electronic Annotation
more info
 
positive regulation of B cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
 
positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
positive regulation of neuron differentiation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of sequence-specific DNA binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription, DNA-templated IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
protein stabilization IDA
Inferred from Direct Assay
more info
PubMed 
regulation of G1/S transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
regulation of transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
regulation of transcription, DNA-templated IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of transcription, DNA-templated TAS
Traceable Author Statement
more info
PubMed 
response to drug IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to lipopolysaccharide IMP
Inferred from Mutant Phenotype
more info
PubMed 
transcription from RNA polymerase II promoter IMP
Inferred from Mutant Phenotype
more info
PubMed 
transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
RNA polymerase II transcription factor complex ISO
Inferred from Sequence Orthology
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
nuclear chromatin ISO
Inferred from Sequence Orthology
more info
 
nuclear nucleosome IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
protein complex ISO
Inferred from Sequence Orthology
more info
 
transcription factor complex IDA
Inferred from Direct Assay
more info
PubMed 
transcription factor complex IPI
Inferred from Physical Interaction
more info
PubMed 
transcription factor complex ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
transcription factor E2-alpha
Names
transcription factor E2-alpha
transcription factor A1
transcription factor E2a
immunoglobulin enhancer-binding factor E12/E47

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164147.1NP_001157619.1  transcription factor E2-alpha isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC152062
    Consensus CDS
    CCDS48636.1
    UniProtKB/TrEMBL
    E9PWE2
    Related
    ENSMUSP00000100979, OTTMUSP00000020640, ENSMUST00000105342, OTTMUST00000045822
    Conserved Domains (1) summary
    cd00083
    Location:546606
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
  2. NM_001164148.1NP_001157620.1  transcription factor E2-alpha isoform 2

    See proteins identical to NP_001157620.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate splice site in the coding region, compared to variant 1. The resulting isoform (2) lacks an internal aa, compared to isoform 1.
    Source sequence(s)
    AC152062
    Consensus CDS
    CCDS48634.1
    UniProtKB/Swiss-Prot
    P15806
    Related
    ENSMUSP00000020377, OTTMUSP00000020638, ENSMUST00000020377, OTTMUST00000045820
    Conserved Domains (1) summary
    cd00083
    Location:545605
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
  3. NM_001164149.1NP_001157621.1  transcription factor E2-alpha isoform 3

    See proteins identical to NP_001157621.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has two alternate splice sites in the coding region, compared to variant 1. The resulting isoform (3) lacks two internal aa, compared to isoform 1.
    Source sequence(s)
    AC152062
    Consensus CDS
    CCDS48630.1
    UniProtKB/Swiss-Prot
    P15806
    Related
    ENSMUSP00000100983, OTTMUSP00000020635, ENSMUST00000105346, OTTMUST00000045817
    Conserved Domains (1) summary
    cd00083
    Location:544604
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
  4. NM_001164150.1NP_001157622.1  transcription factor E2-alpha isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) has an alternate penultimate coding exon, compared to variant 1. The resulting isoform (4) has a distinct segment in the C-terminal region, compared to isoform 1.
    Source sequence(s)
    AC152062
    Consensus CDS
    CCDS48635.1
    UniProtKB/TrEMBL
    E9PVV1
    Related
    ENSMUSP00000100981, OTTMUSP00000020639, ENSMUST00000105344, OTTMUST00000045821
    Conserved Domains (1) summary
    cd00083
    Location:543603
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
  5. NM_001164151.1NP_001157623.1  transcription factor E2-alpha isoform 5

    See proteins identical to NP_001157623.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) has an alternate splice site and an alternate penultimate coding exon, compared to variant 1. The resulting isoform (5) lacks an internal aa and has a distinct segment in the C-terminal region, compared to isoform 1.
    Source sequence(s)
    AC152062
    Consensus CDS
    CCDS48632.1
    UniProtKB/Swiss-Prot
    P15806
    Related
    ENSMUSP00000020379, OTTMUSP00000020645, ENSMUST00000020379, OTTMUST00000045827
    Conserved Domains (1) summary
    cd00083
    Location:542602
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
  6. NM_001164152.1NP_001157624.1  transcription factor E2-alpha isoform 6

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) has an alternate splice site and an alternate penultimate coding exon, compared to variant 1. The resulting isoform (6) lacks an internal aa and has a distinct segment in the C-terminal region, compared to isoform 1.
    Source sequence(s)
    AC152062
    Consensus CDS
    CCDS48633.1
    UniProtKB/TrEMBL
    E9PVV2
    Related
    ENSMUSP00000100980, OTTMUSP00000020641, ENSMUST00000105343, OTTMUST00000045823
    Conserved Domains (1) summary
    cd00083
    Location:542602
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
  7. NM_001164153.1NP_001157625.1  transcription factor E2-alpha isoform 7

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) has an alternate splice site and an alternate penultimate coding exon, compared to variant 1. The resulting isoform (7) lacks an internal aa and has a distinct segment in the C-terminal region, compared to isoform 1.
    Source sequence(s)
    AC152062
    Consensus CDS
    CCDS48631.1
    UniProtKB/TrEMBL
    E9PWE4
    Related
    ENSMUSP00000100977, OTTMUSP00000020637, ENSMUST00000105340, OTTMUST00000045819
    Conserved Domains (1) summary
    cd00083
    Location:541601
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
  8. NM_011548.4NP_035678.3  transcription factor E2-alpha isoform 8

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) has two alternate splice sites and an alternate penultimate coding exon, compared to variant 1. The resulting isoform (8) lacks two internal aa and has a distinct segment in the C-terminal region, compared to isoform 1.
    Source sequence(s)
    AC152062
    Consensus CDS
    CCDS24022.1
    UniProtKB/Swiss-Prot
    P15806
    Related
    ENSMUSP00000100982, OTTMUSP00000020636, ENSMUST00000105345, OTTMUST00000045818
    Conserved Domains (1) summary
    cd00083
    Location:541601
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p2 C57BL/6J

Genomic

  1. NC_000076.6 

    Range
    80409165..80433653
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. AC_000032.1 

    Range
    81426533..81451021
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)