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    Gpx1 glutathione peroxidase 1 [ Mus musculus (house mouse) ]

    Gene ID: 14775, updated on 24-Jun-2016
    Official Symbol
    Gpx1provided by MGI
    Official Full Name
    glutathione peroxidase 1provided by MGI
    Primary source
    MGI:MGI:104887
    See related
    Ensembl:ENSMUSG00000063856 Vega:OTTMUSG00000050754
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gpx; CGPx; GPx-1; GSHPx-1; AI195024; AL033363
    Summary
    This gene product belongs to the family of glutathione peroxidase, which functions in the detoxification of hydrogen peroxide. It contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    9 59.24 cM; 9 F1
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 9 NC_000075.6 (108339080..108340342)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (108241607..108242671)

    Chromosome 9 - NC_000075.6Genomic Context describing neighboring genes Neighboring gene T cell leukemia translocation altered gene Neighboring gene ras homolog family member A Neighboring gene ubiquitin specific peptidase 4 (proto-oncogene) Neighboring gene ribosomal protein S2, pseudogene 11 Neighboring gene RIKEN cDNA 1700102P08 gene Neighboring gene coiled-coil domain containing 36

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    SH3 domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    glutathione binding ISO
    Inferred from Sequence Orthology
    more info
     
    glutathione peroxidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    glutathione peroxidase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    glutathione peroxidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    peroxidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    phospholipid-hydroperoxide glutathione peroxidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    selenium binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    UV protection ISO
    Inferred from Sequence Orthology
    more info
     
    angiogenesis involved in wound healing IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    blood vessel endothelial cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell redox homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    endothelial cell development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    fat cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    glutathione metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    heart contraction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    heart contraction ISO
    Inferred from Sequence Orthology
    more info
     
    hydrogen peroxide catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    hydrogen peroxide catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    interaction with symbiont IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    intrinsic apoptotic signaling pathway in response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    lipid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    myoblast proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    myotube differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of cysteine-type endopeptidase activity involved in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of extrinsic apoptotic signaling pathway via death domain receptors ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of inflammatory response to antigenic stimulus IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of release of cytochrome c from mitochondria ISO
    Inferred from Sequence Orthology
    more info
     
    oxidation-reduction process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of protein kinase B signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein oxidation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of gene expression, epigenetic ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of mammary gland epithelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of neuron apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of proteasomal protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    response to gamma radiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    response to hydrogen peroxide IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to hydrogen peroxide ISO
    Inferred from Sequence Orthology
    more info
     
    response to hydroperoxide IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to lipid hydroperoxide ISO
    Inferred from Sequence Orthology
    more info
     
    response to oxidative stress IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to reactive oxygen species IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to selenium ion ISO
    Inferred from Sequence Orthology
    more info
     
    response to symbiotic bacterium IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    response to toxic substance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to wounding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to xenobiotic stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    sensory perception of sound IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    skeletal muscle fiber development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    skeletal muscle tissue regeneration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    temperature homeostasis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    triglyceride metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    vasodilation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    colocalizes_with Lewy body ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    glutathione peroxidase 1
    Names
    cellular glutathione peroxidase
    selenium-dependent glutathione peroxidase 1
    NP_032186.2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008160.6NP_032186.2  glutathione peroxidase 1

      See identical proteins and their annotated locations for NP_032186.2

      Status: REVIEWED

      Source sequence(s)
      BC086649, CK628430
      Consensus CDS
      CCDS23522.1
      UniProtKB/Swiss-Prot
      P11352
      Related
      ENSMUSP00000081010, OTTMUSP00000069174, ENSMUST00000082429, OTTMUST00000128632
      Conserved Domains (1) summary
      cd00340
      Location:13190
      GSH_Peroxidase; Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000075.6 Reference GRCm38.p4 C57BL/6J

      Range
      108339080..108340342
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)