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Smo smoothened homolog (Drosophila) [ Mus musculus (house mouse) ]

Gene ID: 319757, updated on 22-Mar-2015
Official Symbol
Smoprovided by MGI
Official Full Name
smoothened homolog (Drosophila)provided by MGI
Primary source
MGI:MGI:108075
See related
Ensembl:ENSMUSG00000001761; Vega:OTTMUSG00000013446
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
bnb; Smoh; smoothened; E130215L21Rik
Orthologs
See Smo in MapViewer
Location:
6 A3.3; 6 12.36 cM
Exon count:
13
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 6 NC_000072.6 (29735497..29761366)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (29685497..29711366)

Chromosome 6 - NC_000072.6Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105242613 Neighboring gene tetraspanin 33 Neighboring gene predicted gene 13717 Neighboring gene S-adenosylhomocysteine hydrolase-like 2 Neighboring gene striatin interacting protein 2

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
G-protein coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Wnt-protein binding IBA
Inferred from Biological aspect of Ancestor
more info
 
drug binding IDA
Inferred from Direct Assay
more info
PubMed 
drug binding ISO
Inferred from Sequence Orthology
more info
 
patched binding IBA
Inferred from Biological aspect of Ancestor
more info
 
patched binding ISO
Inferred from Sequence Orthology
more info
 
signal transducer activity IEA
Inferred from Electronic Annotation
more info
 
transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
G-protein coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
anterior/posterior pattern specification IMP
Inferred from Mutant Phenotype
more info
PubMed 
astrocyte activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
atrial septum morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
axon extension involved in axon guidance ISO
Inferred from Sequence Orthology
more info
 
cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell fate specification IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
central nervous system development IGI
Inferred from Genetic Interaction
more info
PubMed 
central nervous system neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
cerebellar cortex morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
cerebral cortex development IMP
Inferred from Mutant Phenotype
more info
PubMed 
detection of cell density by contact stimulus involved in contact inhibition ISO
Inferred from Sequence Orthology
more info
 
determination of left/right asymmetry in lateral mesoderm IMP
Inferred from Mutant Phenotype
more info
PubMed 
determination of left/right symmetry IMP
Inferred from Mutant Phenotype
more info
PubMed 
developmental growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
digestive tract development IMP
Inferred from Mutant Phenotype
more info
PubMed 
dorsal/ventral neural tube patterning IMP
Inferred from Mutant Phenotype
more info
PubMed 
dorsal/ventral pattern formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
embryonic organ development IGI
Inferred from Genetic Interaction
more info
PubMed 
epithelial-mesenchymal cell signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
forebrain morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
hair follicle morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
heart looping IMP
Inferred from Mutant Phenotype
more info
PubMed 
heart morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
homeostasis of number of cells within a tissue IDA
Inferred from Direct Assay
more info
PubMed 
in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
left/right axis specification IMP
Inferred from Mutant Phenotype
more info
PubMed 
mammary gland epithelial cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
mesenchymal to epithelial transition involved in metanephric renal vesicle formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
midgut development IMP
Inferred from Mutant Phenotype
more info
PubMed 
multicellular organism growth IGI
Inferred from Genetic Interaction
more info
PubMed 
multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
multicellular organismal development IEA
Inferred from Electronic Annotation
more info
 
myoblast migration IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of DNA binding IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of DNA binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of epithelial cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of hair follicle development IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transcription from RNA polymerase II promoter IMP
Inferred from Mutant Phenotype
more info
PubMed 
neural crest cell migration IGI
Inferred from Genetic Interaction
more info
PubMed 
odontogenesis of dentin-containing tooth IMP
Inferred from Mutant Phenotype
more info
PubMed 
ossification IMP
Inferred from Mutant Phenotype
more info
PubMed 
osteoblast differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
pancreas morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
pattern specification process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of branching involved in ureteric bud morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of epithelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of hh target transcription factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of mesenchymal cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of neuroblast proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of protein import into nucleus IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of smoothened signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein localization to nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein stabilization IDA
Inferred from Direct Assay
more info
PubMed 
regulation of gene expression IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of heart morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of stem cell maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
skeletal muscle fiber development IMP
Inferred from Mutant Phenotype
more info
PubMed 
smoothened signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
smoothened signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
smoothened signaling pathway ISO
Inferred from Sequence Orthology
more info
 
smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
smoothened signaling pathway involved in ventral spinal cord patterning IMP
Inferred from Mutant Phenotype
more info
PubMed 
somite development IMP
Inferred from Mutant Phenotype
more info
PubMed 
thalamus development IMP
Inferred from Mutant Phenotype
more info
PubMed 
type B pancreatic cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
vasculogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
ventral midline determination IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
colocalizes_with Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
axonal growth cone ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with caveola ISO
Inferred from Sequence Orthology
more info
 
cell projection IEA
Inferred from Electronic Annotation
more info
 
ciliary membrane IDA
Inferred from Direct Assay
more info
PubMed 
cilium IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
dendrite ISO
Inferred from Sequence Orthology
more info
 
dendritic growth cone ISO
Inferred from Sequence Orthology
more info
 
extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
postsynaptic density ISO
Inferred from Sequence Orthology
more info
 
primary cilium IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
smoothened homolog
Names
smoothened homolog
bent body

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_176996.4NP_795970.3  smoothened homolog precursor

    See proteins identical to NP_795970.3

    Status: VALIDATED

    Source sequence(s)
    AC069469, AK081050, AW555326, BB659739, CA749812, CN665198
    Consensus CDS
    CCDS19965.1
    UniProtKB/Swiss-Prot
    P56726
    UniProtKB/TrEMBL
    Q4VBD5
    UniProtKB/TrEMBL
    Q8BJN8
    Related
    ENSMUSP00000001812, OTTMUSP00000014435, ENSMUST00000001812, OTTMUST00000032499
    Conserved Domains (2) summary
    cd07451
    Location:70200
    CRD_SMO; Cysteine-rich domain of the smoothened receptor (Smo) integral membrane protein
    cl19289
    Location:224559
    7tm_2; 7 transmembrane receptor (Secretin family)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000072.6 Reference GRCm38.p3 C57BL/6J

    Range
    29735497..29761366
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006505106.2XP_006505169.1  

    Conserved Domains (2) summary
    cl02447
    Location:166
    CRD_FZ; CRD_domain cysteine-rich domain, also known as Fz (frizzled) domain
    cl19289
    Location:90425
    7tm_2; 7 transmembrane receptor (Secretin family)

Alternate Mm_Celera

Genomic

  1. AC_000028.1 Alternate Mm_Celera

    Range
    29744569..29772611
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)